Journal
BIOMED RESEARCH INTERNATIONAL
Volume 2016, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2016/6191307
Keywords
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Funding
- Wetenschappelijk Fonds Willy Gepts of UZ Brussel
- Methusalem grant of Research Council of Vrije Universiteit Brussel
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Sertoli cell-only syndrome is defined by the complete absence of germ cells in testicular tissues and always results in male infertility. The aetiology often remains unknown. In this paper, we have investigated possible causes of Sertoli cell-only syndrome with a special focus on genetic causes. Our results show that, for a large part of the patients (> 23% in an unselected group), the sex chromosomes are involved. The majority of patients had a Klinefelter syndrome, followed by patients with Yq micro deletions. Array comparative genomic hybridization in a selected group of idiopathic patients showed no known infertility related copy number variations.
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