Tumor-targeting cell membrane-coated nanorings for magnetic-hyperthermia-induced tumor ablation

Magnetic hyperthermia has attracted considerable attention for efficient cancer therapy because of its noninvasive nature, deep tissue penetration, and minimal damage to healthy tissues. Herein, we have fused cancer cell membrane fragments with lipids and cloaked them on magnetic nanorings to form targeted Fe nanorings (TF) for tumor-targeted magnetic hyperthermia-induced tumor ablation. In our approach, cell membrane fragments from cancer cells were fused with lipids to form vesicles, which could efficiently encapsulate magnetic nanorings, thereby forming TF. We observed that TF have high tumor uptake via homotypic targeting, where cancer cells take up TF through membrane fusion. Under an external alternating magnetic field (AMF), TF accumulated in the tumors are heated, driving magnetic-hyperthermia-induced tumor cell death. Our in vitro studies show that self-targeting TF efficiently localized in cancer cells and induced cell death with an AMF, which was shown by a live/dead assay. Our findings demonstrate the potential of TF in tumor ablation, thereby making them promising and efficient nanosystems for tumor-targeted theranostics. Tumor-targeting cell membrane-coated magnetic nanorings for enhanced tumor accumulation and magnetic-hyperthermia-induced tumor ablation.

Automated summary

Magnetic hyperthermia, a noninvasive cancer therapy with deep tissue penetration and minimal damage to healthy tissues, has attracted significant attention. This study developed targeted Fe nanorings (TF) for tumor-targeted magnetic hyperthermia-induced tumor ablation by fusing cancer cell membrane fragments with lipids and cloaking them on magnetic nanorings. The TF showed high tumor uptake and induced tumor cell death under an external alternating magnetic field. These findings demonstrate the potential and efficiency of TF as a nanosystem for tumor-targeted theranostics.