Journal
AGING CELL
Volume -, Issue -, Pages -Publisher
WILEY
DOI: 10.1111/acel.14035
Keywords
biological age; longitudinal study; osteoporosis; proteome-wide study
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The role of circulatory proteomics in osteoporosis is unclear, but proteome-wide profiling holds the potential to offer mechanistic insights into osteoporosis. Through the study of two Chinese cohorts, several proteins associated with osteoporosis were identified and used to generate the biological age of bone, showing a significant correlation with bone mineral density. The findings uncovered new mechanistic insights into osteoporosis, indicating that serum proteomics could be a crucial indicator for evaluating bone aging.
The role of circulatory proteomics in osteoporosis is unclear. Proteome-wide profiling holds the potential to offer mechanistic insights into osteoporosis. Serum proteome with 413 proteins was profiled by liquid chromatography-tandem mass spectrometry (LC-MS/MS) at baseline, and the 2nd, and 3rd follow-ups (7704 person-tests) in the prospective Chinese cohorts with 9.8 follow-up years: discovery cohort (n = 1785) and internal validation cohort (n = 1630). Bone mineral density (BMD) was measured using dual-energy X-ray absorptiometry (DXA) at follow-ups 1 through 3 at lumbar spine (LS) and femoral neck (FN). We used the Light Gradient Boosting Machine (LightGBM) to identify the osteoporosis (OP)-related proteomic features. The relationships between serum proteins and BMD in the two cohorts were estimated by linear mixed-effects model (LMM). Meta-analysis was then performed to explore the combined associations. We identified 53 proteins associated with osteoporosis using LightGBM, and a meta-analysis showed that 22 of these proteins illuminated a significant correlation with BMD (p < 0.05). The most common proteins among them were PHLD, SAMP, PEDF, HPTR, APOA1, SHBG, CO6, A2MG, CBPN, RAIN APOD, and THBG. The identified proteins were used to generate the biological age (BA) of bone. Each 1 SD-year increase in KDM-Proage was associated with higher risk of LS-OP (hazard ratio [HR], 1.25; 95% CI, 1.14-1.36, p = 4.96 x 10(-06)), and FN-OP (HR, 1.13; 95% CI, 1.02-1.23, p = 9.71 x 10(-03)). The findings uncovered that the apolipoproteins, zymoproteins, complements, and binding proteins presented new mechanistic insights into osteoporosis. Serum proteomics could be a crucial indicator for evaluating bone aging.
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