Journal
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
Volume -, Issue -, Pages -Publisher
WILEY
DOI: 10.1111/ceo.14316
Keywords
cornea; corneal tomography; down syndrome; keratoconus
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This study investigated the prevalence, risk factors, and severity of keratoconus in Down syndrome (DS) patients. The results showed that keratoconus is common in DS patients and eye rubbing is a significant risk factor. Screening with corneal tomography is recommended for early detection.
Background: This study investigated the prevalence, risk factors and severity of corneal tomographic features of keratoconus in Down syndrome (DS). Additionally, previous studies indicate anomalous corneal features in DS, without keratoconus, this study characterised corneal features in DS without keratoconus. Methods: This prospective observational study included participants with DS >= 10 years old. Keratoconus diagnosis, risk factors and corneal tomographic characteristics were recorded. Participants underwent slit-lamp biomicroscopy, Scheimpflug corneal tomography, corneal topography and autorefraction. A diagnosis of keratoconus (DS-KC), suspect keratoconus (DS-SK) and non-keratoconus (DS-NK) was made based on expert review of scans by three fellowship trained anterior segment ophthalmologists. Corneal tomography parameters from one eye of each participant were analysed. Results: Keratoconus affected 50 (26.3%) of 190 participants, diagnosed by corneal tomography, topography or slit-lamp signs. Corneal hydrops affected 14.0% of DS-KC participants. Eye rubbing was a significant risk factor for keratoconus (p = 0.036). 175 (92%) participants could undertake corneal tomography of which tomography assessment alone identified 47 (26.9%) DS-KC participants, 64 (36.6%) DS-SK participants and 64 (36.6%) DS-NK participants. Significant differences (p < 0.001) were identified when the DS-KC, DS-SK and DS-NK groups were compared in maximum keratometry and posterior elevation at the thinnest point respectively: median (interquartile range) 50.20 (10.30D), 47.60 (1.95D), 46.50 (2.40D); 24.0 (38.00 mu m), 10.00 (13.75 mu m), 8.00 (6.00 mu m). The DS-SK and DS-NK cohorts had similar minimum pachymetry, however, had several significantly different parameters among which included greater maximum keratometry, posterior elevation at the thinnest point in the DS-SK group. Conclusions: Keratoconus is common in DS. Keratoconus screening with corneal tomography is recommended for early detection.
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