☆ 4.7 Review

Non-coding RNAs in disease: from mechanisms to therapeutics

NATURE REVIEWS GENETICS (2023)

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Article Cardiac & Cardiovascular Systems

Circular RNA CircMAP3K5 Acts as a MicroRNA-22-3p Sponge to Promote Resolution of Intimal Hyperplasia Via TET2-Mediated Smooth Muscle Cell Differentiation

Zhi Zeng et al.

Summary: The study demonstrates that circMAP3K5 acts as a regulator of neointimal hyperplasia by sequestering miR-22-3p to inhibit TET2 expression, and subsequently affecting vascular smooth muscle cell differentiation and proliferation. Targeting the circMAP3K5/miR-22-3p/TET2 axis may offer a potential therapeutic strategy for diseases associated with intimal hyperplasia, including restenosis and atherosclerosis.

CIRCULATION (2021)

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Article Cardiac & Cardiovascular Systems

Long Noncoding RNA MIAT Controls Advanced Atherosclerotic Lesion Formation and Plaque Destabilization

Francesca Fasolo et al.

Summary: The study identified lncRNA MIAT as a key regulator in advanced atherosclerosis, controlling the proliferation, apoptosis, and phenotypic transition of SMCs, as well as the proinflammatory properties of macrophages. Experimental knockdown of MIAT significantly impacted cell behaviors, revealing a potential therapeutic target for atherosclerotic diseases.

CIRCULATION (2021)

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Article Cardiac & Cardiovascular Systems

CARMN Is an Evolutionarily Conserved Smooth Muscle Cell-Specific LncRNA That Maintains Contractile Phenotype by Binding Myocardin

Kunzhe Dong et al.

Summary: CARMN is a highly conserved SMC-specific long noncoding RNA that plays a crucial role in maintaining the contractile phenotype of VSMCs, and it is the first noncoding RNA discovered to interact with myocardin.

CIRCULATION (2021)

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Article Oncology

Long non-coding RNA ANRIL is a potential indicator of disease progression and poor prognosis in acute myeloid leukemia

Zhenqing Tan et al.

Summary: This study revealed that lncRNA ANRIL is significantly increased in AML patients and associated with clinical features and prognosis. High expression of lncRNA ANRIL is correlated with low CR rate and shorter EFS and OS in AML patients.

MOLECULAR MEDICINE REPORTS (2021)

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Review Cell Biology

Gene regulation by long non-coding RNAs and its biological functions

Luisa Statello et al.

Summary: Recent studies have shed new light on the biogenesis and functions of long non-coding RNAs (lncRNAs), showcasing their diverse roles in gene regulation and signaling pathways, particularly in the contexts of neuronal disorders, immune responses, and cancer. The discovery of unique biogenesis pathways and subcellular localizations of lncRNAs has opened up potential therapeutic avenues for targeting lncRNAs in various biological and pathophysiological conditions.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

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Review Chemistry, Medicinal

The role of microRNA-21 in the onset and progression of cancer

Ashutosh Singh et al.

Summary: miRNAs are small noncoding RNAs that play important roles in various cancers, with miR-21 being a potential clinical target and biomarker for early cancer detection. Its upregulation is associated with high oncogenic properties and chemotherapy resistance in multiple cancers.

FUTURE MEDICINAL CHEMISTRY (2021)

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Article Biochemistry & Molecular Biology

NONCODEV6: an updated database dedicated to long non-coding RNA annotation in both animals and plants

Lianhe Zhao et al.

Summary: NONCODE is a comprehensive database focusing on the collection and annotation of noncoding RNAs, especially long non-coding RNAs (lncRNAs) in animals. The latest version, NONCODEV6, not only covers lncRNAs in plants and animals, but also provides updated human lncRNA-disease relationships, tissue expression profiles and predicted function of lncRNAs in common plants, as well as conservation annotation of lncRNAs at transcript level for 23 plant species.

NUCLEIC ACIDS RESEARCH (2021)

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Article Neurosciences

Circulating miR-181 is a prognostic biomarker for amyotrophic lateral sclerosis

Iddo Magen et al.

Summary: The study identified miRNA-based biomarkers in the blood of ALS patients, with miR-181 levels alone or in combination with established protein biomarkers predicting disease severity and prognosis. This approach may enhance the power of clinical trials for ALS and improve patient stratification accuracy.

NATURE NEUROSCIENCE (2021)

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Review Rheumatology

The non-coding RNA interactome in joint health and disease

Shabana A. Ali et al.

Summary: Non-coding RNAs play distinct regulatory roles in joint diseases such as osteoarthritis and rheumatoid arthritis, regulating signaling pathways and biological processes important for normal joint development. Their specific expression profiles in disease states support their roles as promising candidate biomarkers and potential therapeutic targets. A better understanding of the non-coding RNA interactome could lead to new therapies for joint diseases.

NATURE REVIEWS RHEUMATOLOGY (2021)

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Article Multidisciplinary Sciences

SARS-CoV-2 expresses a microRNA-like small RNA able to selectively repress host genes

Paulina Pawlica et al.

Summary: The study found a viral miRNA-like small RNA called CoV2-miR-O7a after SARS-CoV-2 infection, without major changes in host miRNA levels.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Microbiology

Super enhancer-mediated transcription of miR146a-5p drives M2 polarization during Leishmania donovani infection

Sonali Das et al.

Summary: The outcome of Leishmania donovani infection is influenced by the interplay between M1 and M2 macrophages. MiR146a-5p plays a crucial role in regulating macrophage polarization, phagocytosis, and parasite survivability during infection. Additionally, a novel role of BRD4/p300-dependent super-enhancer in controlling miR146a expression and mediating M2 polarization and immune suppression was discovered.

PLOS PATHOGENS (2021)

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Article Cell Biology

Role of miR-2392 in driving SARS-CoV-2 infection

J. Tyson McDonald et al.

Summary: The research demonstrates that miR-2392 is associated with SARS-CoV-2 infection, with potential for use in COVID-19 detection and as a target for antiviral therapy. Targeting miR-2392 can significantly reduce SARS-CoV-2 viability, indicating a potential treatment for COVID-19.

CELL REPORTS (2021)

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Article Surgery

miR-21 antagonism reprograms macrophage metabolism and abrogates chronic allograft vasculopathy

Vera Usuelli et al.

Summary: The study found that miR-21 is overexpressed in chronic allograft vasculopathy (CAV) in both murine and human samples, and targeting miR-21 delays the onset of CAV by reprogramming macrophage metabolism.

AMERICAN JOURNAL OF TRANSPLANTATION (2021)

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Article Biochemistry & Molecular Biology

Evidence That Regulation of Pri-miRNA/miRNA Expression Is Not a General Rule of miPEPs Function in Humans

Anne Prel et al.

Summary: Some miRNAs are located in long non-coding RNA precursors, which may potentially encode miPEPs. While plant miPEPs enhance the transcription of their own pri-miRNAs, it is not a general rule for human miPEPs to regulate their own miRNAs.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biology

Virus-Induced Tumorigenesis and IFN System

Marco Iuliano et al.

Summary: This review focuses on the complex relationship between viral infections and tumorigenesis, highlighting the regulatory crosstalk between viral components and the type I interferon system. Viruses promote tumor development by altering cellular pathways, while type I interferons play a crucial role in antiviral defense and immune response regulation.

BIOLOGY-BASEL (2021)

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Review Cell Biology

CircRNAs: role in human diseases and potential use as biomarkers

Lorena Verduci et al.

Summary: Circular RNAs (circRNAs) are a unique class of endogenous RNAs characterized by a covalent loop structure, high stability, and tissue specificity. Their main mode of action is sponging microRNAs, but they may also have the ability to bind specific proteins and encode short proteins. CircRNAs play various functional roles in human diseases, serving as potential biomarkers due to their stable nature and remarkable tissue specificity.

CELL DEATH & DISEASE (2021)

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Article Multidisciplinary Sciences

Coding and non-coding roles of MOCCI (C15ORF48) coordinate to regulate host inflammation and immunity

Cheryl Q. E. Lee et al.

Summary: The study identifies a mito-SEP named MOCCI, which can replace NDUFA4 during inflammation to reduce mitochondrial membrane potential and ROS production, providing cell protection and suppressing immune responses. Additionally, the MOCCI transcript generates miR-147b, which enhances antiviral immune responses.

NATURE COMMUNICATIONS (2021)

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Article Medicine, General & Internal

Quantification of long non-coding RNAs using qRT-PCR: comparison of different cDNA synthesis methods and RNA stability

Tomasz Kolenda et al.

Summary: This study tested the influence of different commercially available cDNA synthesis kits on RNA degradation and found that cDNA synthesized using random hexamer primers preceded by polyA-tailing and adaptor-anchoring steps enhances the specificity and sensitivity of lncRNA quantification. In most cases, RNA degradation does not affect lncRNA quantification, as these molecules have good stability.

ARCHIVES OF MEDICAL SCIENCE (2021)

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Article Biochemistry & Molecular Biology

Structured elements drive extensive circular RNA translation

Chun-Kan Chen et al.

Summary: The study identified a high-throughput screening method to systematically discover RNA sequences that can direct circular RNA (circRNA) translation. Complementarity of 18S rRNA and structured RNA elements play important roles in driving circRNA translation. CircRNA-encoded proteins have tissue-specific distribution and play a role in antigen presentation.

MOLECULAR CELL (2021)

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Article Biotechnology & Applied Microbiology

The RNA Atlas expands the catalog of human non-coding RNAs

Lucia Lorenzi et al.

Summary: The study identified numerous novel non-coding RNAs from 300 human tissues and cell lines, expanding the existing catalog of ncRNAs. By analyzing pre-mRNA abundance estimates from total RNA sequencing, the research revealed several microRNAs and long non-coding RNAs with potential roles in regulating protein-coding genes and pathways.

NATURE BIOTECHNOLOGY (2021)

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Article Biotechnology & Applied Microbiology

Noncoding RNA therapeutics - challenges and potential solutions

Melanie Winkle et al.

Summary: In recent years, RNA-based therapies have gained FDA approval, but there are still challenges in targeting ncRNAs. Therapeutic targeting of noncoding RNAs has the potential to become a new approach for treating diseases such as cancer.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Review Microbiology

Structural biology of SARS-CoV-2 and implications for therapeutic development

Haitao Yang et al.

Summary: The COVID-19 pandemic caused by SARS-CoV-2 has led to an unprecedented global health crisis, with limited therapeutic options available. Understanding the structure and function of the 29 proteins encoded by SARS-CoV-2 is crucial for developing novel therapeutics and treatment interventions. These proteins play various roles in the viral life cycle, from entry into host cells to genome replication and transcription, highlighting their potential as targets for therapeutic interventions.

NATURE REVIEWS MICROBIOLOGY (2021)

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Review Immunology

The Role of microRNAs and Long Non-Coding RNAs in the Regulation of the Immune Response to Mycobacterium tuberculosis Infection

Manikuntala Kundu et al.

Summary: Non-coding RNAs, including miRNAs and lncRNAs, play crucial roles in the host immune response to tuberculosis infection, regulating host defense mechanisms and impacting the outcome of infection. miRNAs are involved in regulating host signaling pathways linked to inflammation, autophagy, apoptosis, and macrophage polarization upon infection with M. tuberculosis, while lncRNAs interact with chromatin remodelers, regulate gene expression, and function as miRNA sponges.Targeting miRNAs is an emerging option for host-directed therapies, and understanding the role of non-coding RNAs is essential for the development of RNA-based thera

FRONTIERS IN IMMUNOLOGY (2021)

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Article Oncology

Ibrutinib Plus Venetoclax for First-Line Treatment of Chronic Lymphocytic Leukemia: Primary Analysis Results From the Minimal Residual Disease Cohort of the Randomized Phase II CAPTIVATE Study

William G. Wierda et al.

Summary: The study evaluated the potential for fixed-duration treatment in CLL patients using MRD-guided therapy interruption, with a 95% 1-year DFS rate in placebo randomly assigned patients with Confirmed uMRD suggesting promise for this approach in first-line CLL treatment.

JOURNAL OF CLINICAL ONCOLOGY (2021)

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Article Cardiac & Cardiovascular Systems

Novel antisense therapy targeting microRNA-132 in patients with heart failure: results of a first-in-human Phase 1b randomized, double-blind, placebo-controlled study

Jorg Taubel et al.

Summary: The study evaluated the safety and mechanism of action of CDR132L in patients with chronic ischemic heart failure, showing that CDR132L is safe and well tolerated, effectively reducing miR-132 levels and improving cardiac function.

EUROPEAN HEART JOURNAL (2021)

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Article Cardiac & Cardiovascular Systems

Novel antisense therapy targeting microRNA-132 in patients with heart failure: results of a first-in-human Phase 1b randomized, double-blind, placebo-controlled study

Jorg Taubel et al.

Summary: The first-in-class miR-132 inhibitor, CDR132L, showed good safety and tolerability in HF patients. It effectively reduced miR-132 levels, decreased NT-proBNP levels, and potentially improved cardiac function.

EUROPEAN HEART JOURNAL (2021)

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Article Biochemistry & Molecular Biology

Micropeptide CIP2A-BP encoded by LINC00665 inhibits triple-negative breast cancer progression

Binbin Guo et al.

EMBO JOURNAL (2020)

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Article Cardiac & Cardiovascular Systems

The LINC00961 transcript and its encoded micropeptide, small regulatory polypeptide of amino acid response, regulate endothelial cell function

Helen L. Spencer et al.

CARDIOVASCULAR RESEARCH (2020)

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Review Cardiac & Cardiovascular Systems

Preclinical and Clinical Development of Noncoding RNA Therapeutics for Cardiovascular Disease

Cheng-Kai Huang et al.

CIRCULATION RESEARCH (2020)

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Article Gastroenterology & Hepatology

Non-coding RNAs in GI cancers: from cancer hallmarks to clinical utility

Mihnea Paul Dragomir et al.

GUT (2020)

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Article Immunology

LncRNA-encoded polypeptide ASRPS inhibits triple-negative breast cancer angiogenesis

Yirong Wang et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

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Letter Infectious Diseases

An interactive web-based dashboard to track COVID-19 in real time

Ensheng Dong et al.

LANCET INFECTIOUS DISEASES (2020)

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Article Endocrinology & Metabolism

Profiling of differentially expressed circular RNAs in peripheral blood mononuclear cells from Alzheimer's disease patients

Yanxin Li et al.

METABOLIC BRAIN DISEASE (2020)

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Article Multidisciplinary Sciences

Loss of p53 drives neuron reprogramming in head and neck cancer

Moran Amit et al.

NATURE (2020)

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Article Clinical Neurology

Circulating Circular RNAs as Biomarkers for the Diagnosis and Prediction of Outcomes in Acute Ischemic Stroke

Lei Zuo et al.

STROKE (2020)

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Article Multidisciplinary Sciences

A IncRNA-SWI/SNF complex crosstalk controls transcriptional activation at specific promoter regions

Elena Grossi et al.

NATURE COMMUNICATIONS (2020)

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Article Cell Biology

Small extracellular vesicles deliver miR-21 and miR-217 as pro-senescence effectors to endothelial cells

Emanuela Mensa et al.

JOURNAL OF EXTRACELLULAR VESICLES (2020)

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Article Biochemistry & Molecular Biology

Circular RNA Expression Profiles in Plasma from Patients with Heart Failure Related to Platelet Activity

Yeying Sun et al.

BIOMOLECULES (2020)

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Article Oncology

Phase 1 study of MRX34, a liposomal miR-34a mimic, in patients with advanced solid tumours

David S. Hong et al.

BRITISH JOURNAL OF CANCER (2020)

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Article Biochemistry & Molecular Biology

Distinct Processing of lncRNAs Contributes to Non-conserved Functions in Stem Cells

Chun-Jie Guo et al.

CELL (2020)

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Article Cardiac & Cardiovascular Systems

Endothelium-Targeted Deletion of microRNA-15a/16-1 Promotes Poststroke Angiogenesis and Improves Long-Term Neurological Recovery

Ping Sun et al.

CIRCULATION RESEARCH (2020)

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Article Biochemistry & Molecular Biology

Endothelium-targeted deletion of the miR-15a/16-1 cluster ameliorates blood-brain barrier dysfunction in ischemic stroke

Feifei Ma et al.

SCIENCE SIGNALING (2020)

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Article Multidisciplinary Sciences

Exosomal miR-21 promotes proliferation, invasion and therapy resistance of colon adenocarcinoma cells through its target PDCD4

Li-Hua Sun et al.

SCIENTIFIC REPORTS (2020)

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Article Cardiac & Cardiovascular Systems

AntimiR-21 Prevents Myocardial Dysfunction in a Pig Model of Ischemia/Reperfusion Injury

Rabea Hinkel et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

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Article Genetics & Heredity

Circular RNA-Expression Profiling Reveals a Potential Role of Hsa_circ_0097435 in Heart Failure via Sponging Multiple MicroRNAs

Jiaqi Han et al.

FRONTIERS IN GENETICS (2020)

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Article Multidisciplinary Sciences

U1 snRNP regulates chromatin retention of noncoding RNAs

Yafei Yin et al.

NATURE (2020)

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Article Cardiac & Cardiovascular Systems

Identification of Long Noncoding RNA H19 as a New Biomarker and Therapeutic Target in Right Ventricular Failure in Pulmonary Arterial Hypertension

Junichi Omura et al.

CIRCULATION (2020)

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Review Biochemistry & Molecular Biology

CircRNAs: biogenesis, functions, and role in drug-resistant Tumours

Shuo Ma et al.

MOLECULAR CANCER (2020)

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Article Cardiac & Cardiovascular Systems

Roles of MicroRNA-122 in Cardiovascular Fibrosis and Related Diseases

Ying Liu et al.

CARDIOVASCULAR TOXICOLOGY (2020)

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Review Biochemistry & Molecular Biology

Targeting RNA structures in diseases with small molecules

Yanqiu Shao et al.

SPOTLIGHT ON CHINA: RNA (2020)

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Review Biochemistry & Molecular Biology

Noncoding RNAs versus Protein Biomarkers in Cardiovascular Disease

Christian Schulte et al.

TRENDS IN MOLECULAR MEDICINE (2020)

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Article Biochemistry & Molecular Biology

Identification of miPEP133 as a novel tumor-suppressor microprotein encoded by miR-34a pri-miRNA

Min Kang et al.

MOLECULAR CANCER (2020)

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Review Virology

Non-Coding RNAs and SARS-Related Coronaviruses

Hanna Henzinger et al.

VIRUSES-BASEL (2020)

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Article Multidisciplinary Sciences

Common diseases alter the physiological age-related blood microRNA profile

Tobias Fehlmann et al.

NATURE COMMUNICATIONS (2020)

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Article Multidisciplinary Sciences

The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans

Shiuli Agarwal et al.

NATURE COMMUNICATIONS (2020)

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Article Immunology

Competing endogenous RNA network profiling reveals novel host dependency factors required for MERS-CoV propagation

Xi Zhang et al.

EMERGING MICROBES & INFECTIONS (2020)

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Review Cardiac & Cardiovascular Systems

Circulating non-coding RNAs in biomarker-guided cardiovascular therapy: a novel tool for personalized medicine?

David de Gonzalo-Calvo et al.

EUROPEAN HEART JOURNAL (2019)

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Review Cell Biology

Regulation of microRNA function in animals

Luca F. R. Gebert et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

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Article Biochemistry & Molecular Biology

LncRNADisease 2.0: an updated database of long non-coding RNA-associated diseases

Zhenyu Bao et al.

NUCLEIC ACIDS RESEARCH (2019)

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Article Cardiac & Cardiovascular Systems

Long Noncoding RNA CPR (Cardiomyocyte Proliferation Regulator) Regulates Cardiomyocyte Proliferation and Cardiac Repair

Murugavel Ponnusamy et al.

CIRCULATION (2019)

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Article Oncology

Serum Levels of MicroRNA-371a-3p (M371 Test) as a New Biomarker of Testicular Germ Cell Tumors: Results of a Prospective Multicentric Study

Klaus-Peter Dieckmann et al.

JOURNAL OF CLINICAL ONCOLOGY (2019)

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Article Multidisciplinary Sciences

LINC00116 codes for a mitochondrial peptide linking respiration and lipid metabolism

Anastasia Chugunova et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Editorial Material Biochemistry & Molecular Biology

Circle the Wagons: Circular RNAs Control Innate Immunity

Jeremy E. Wilusz

CELL (2019)

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Article Biochemistry & Molecular Biology

Small RNA Sequencing across Diverse Biofluids Identifies Optimal Methods for exRNA Isolation

Srimeenakshi Srinivasan et al.

CELL (2019)

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Article Oncology

miR-31-3p Expression and Benefit from Anti-EGFR Inhibitors in Metastatic Colorectal Cancer Patients Enrolled in the Prospective Phase II PROSPECT-C Trial

Gayathri Anandappa et al.

CLINICAL CANCER RESEARCH (2019)

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Article Endocrinology & Metabolism

Comprehensive Analysis of Circulating miRNAs in the Plasma of Patients With Pituitary Adenomas

Kinga Nemeth et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2019)

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Review Cardiac & Cardiovascular Systems

Circular RNAs open a new chapter in cardiovascular biology

Simona Aufiero et al.

NATURE REVIEWS CARDIOLOGY (2019)

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Article Cardiac & Cardiovascular Systems

Identification of circular RNA Hsa_circ_0001879 and Hsa_circ_0004104 as novel biomarkers for coronary artery disease

Laiyuan Wang et al.

ATHEROSCLEROSIS (2019)

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Article Biotechnology & Applied Microbiology

PTB-AS, a Novel Natural Antisense Transcript, Promotes Glioma Progression by Improving PTBP1 mRNA Stability with SND1

Liyuan Zhu et al.

MOLECULAR THERAPY (2019)

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Review Cardiac & Cardiovascular Systems

RNA-based diagnostic and therapeutic strategies for cardiovascular disease

Dongchao Lu et al.

NATURE REVIEWS CARDIOLOGY (2019)

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Article Biochemistry & Molecular Biology

Decrypting noncoding RNA interactions, structures, and functional networks

Muller Fabbri et al.

GENOME RESEARCH (2019)

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Review Biochemistry & Molecular Biology

An Overview of Circular RNAs and Their Implications in Myotonic Dystrophy

Karol Czubak et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Cell Biology

Glioblastoma-Associated Microglia Reprogramming Is Mediated by Functional Transfer of Extracellular miR-21

Erik R. Abels et al.

CELL REPORTS (2019)

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Article Oncology

XIST-Promoter Demethylation as Tissue Biomarker for Testicular Germ Cell Tumors and Spermatogenesis Quality

Joao Lobo et al.

CANCERS (2019)

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Article Cell Biology

LncRNA MALAT1 shuttled by bone marrow-derived mesenchymal stem cells-secreted exosomes alleviates osteoporosis through mediating microRNA-34c/SATB2 axis

Xucheng Yang et al.

AGING-US (2019)

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Review Biochemistry & Molecular Biology

The Role of Non-coding RNAs in Oncology

Frank J. Slack et al.

CELL (2019)

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Article Neurosciences

An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations

Umber Dube et al.

NATURE NEUROSCIENCE (2019)

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Article Biochemistry & Molecular Biology

Selective Small-Molecule Targeting of a Triple Helix Encoded by the Long Noncoding RNA, MALAT1

Fardokht A. Abulwerdi et al.

ACS CHEMICAL BIOLOGY (2019)

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Article Genetics & Heredity

Enhancer LncRNAs Influence Chromatin Interactions in Different Ways

Yue Hou et al.

FRONTIERS IN GENETICS (2019)

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Article Dermatology

A MicroRNA-29 Mimic (Remlarsen) Represses Extracellular Matrix Expression and Fibroplasia in the Skin

Corrie L. Gallant-Behm et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2019)

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Review Genetics & Heredity

PIWI-interacting RNAs: small RNAs with big functions

Deniz M. Ozata et al.

NATURE REVIEWS GENETICS (2019)

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Article Biochemistry & Molecular Biology

HMDD v3.0: a database for experimentally supported human microRNA-disease associations

Zhou Huang et al.

NUCLEIC ACIDS RESEARCH (2019)

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Article Biochemistry & Molecular Biology

GENCODE reference annotation for the human and mouse genomes

Adam Frankish et al.

NUCLEIC ACIDS RESEARCH (2019)

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Article Biochemistry & Molecular Biology

miRBase: from microRNA sequences to function

Ana Kozomara et al.

NUCLEIC ACIDS RESEARCH (2019)

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Article Medicine, Research & Experimental

Long noncoding RNA Malat1 regulates differential activation of macrophages and response to lung injury

Huachun Cui et al.

JCI INSIGHT (2019)

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Article Oncology

Validation of miR-31-3p Expression to Predict Cetuximab Efficacy When Used as First-Line Treatment in RAS Wild-Type Metastatic Colorectal Cancer

Pierre Laurent-Puig et al.

CLINICAL CANCER RESEARCH (2019)

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Review Oncology

Let-7 as biomarker, prognostic indicator, and therapy for precision medicine in cancer

Evgeny Chirshev et al.

CLINICAL AND TRANSLATIONAL MEDICINE (2019)

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Review Cardiac & Cardiovascular Systems

Non-coding RNAs in cardiovascular diseases: diagnostic and therapeutic perspectives

Wolfgang Poller et al.

EUROPEAN HEART JOURNAL (2018)

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Article Oncology

Novel Role of FBXW7 Circular RNA in Repressing Glioma Tumorigenesis

Yibing Yang et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2018)

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Article Clinical Neurology

MicroRNAs in CSF as prodromal biomarkers for Huntington disease in the PREDICT-HD study

Eric R. Reed et al.

NEUROLOGY (2018)

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Article Oncology

Novel Role of FBXW7 Circular RNA in Repressing Glioma Tumorigenesis

Yibing Yang et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2018)

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Review Chemistry, Multidisciplinary

The circulating non-coding RNA landscape for biomarker research: lessons and prospects from cardiovascular diseases

Ewa Stepien et al.

ACTA PHARMACOLOGICA SINICA (2018)

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Article Oncology

Serum microRNA signatures and metabolomics have high diagnostic value in gastric cancer

Hai-Ning Liu et al.

BMC CANCER (2018)

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Review Biochemistry & Molecular Biology

Metazoan MicroRNAs

David P. Bartel

CELL (2018)

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Article Cardiac & Cardiovascular Systems

The Long Noncoding RNA CAREL Controls Cardiac Regeneration

Benzhi Cai et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2018)

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Review Oncology

Clinical utility of circulating non-coding RNAs - an update

Simone Anfossi et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

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Article Biotechnology & Applied Microbiology

Principles for targeting RNA with drug-like small molecules

Katherine Deigan Warner et al.

NATURE REVIEWS DRUG DISCOVERY (2018)

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Review Genetics & Heredity

Towards a complete map of the human long non-coding RNA transcriptome

Barbara Uszczynska-Ratajczak et al.

NATURE REVIEWS GENETICS (2018)

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Article Biochemistry & Molecular Biology

A novel protein encoded by the circular form of the SHPRH gene suppresses glioma tumorigenesis

Maolei Zhang et al.

ONCOGENE (2018)

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Article Multidisciplinary Sciences

Specific serum and CSF microRNA profiles distinguish sporadic behavioural variant of frontotemporal dementia compared with Alzheimer patients and cognitively healthy controls

Johannes Denk et al.

PLOS ONE (2018)

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Review Genetics & Heredity

Micropeptides Encoded in Transcripts Previously Identified as Long Noncoding RNAs: A New Chapter in Transcriptomics and Proteomics

Fouzia Yeasmin et al.

FRONTIERS IN GENETICS (2018)

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Review Biochemistry & Molecular Biology

The Dual Role of MicroRNAs in Colorectal Cancer Progression

Lei Ding et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Article Neurosciences

Circulating miR-127-3p as a Potential Biomarker for Differential Diagnosis in Frontotemporal Dementia

Paola Piscopo et al.

JOURNAL OF ALZHEIMERS DISEASE (2018)

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Article Immunology

LncRNAs expression profile in peripheral blood mononuclear cells from multiple sclerosis patients

Chiara Fenoglio et al.

JOURNAL OF NEUROIMMUNOLOGY (2018)

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Article Multidisciplinary Sciences

OncomiR-10b hijacks the small molecule inhibitor linifanib in human cancers

Paloma del C. Monroig-Bosque et al.

SCIENTIFIC REPORTS (2018)

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Article Cardiac & Cardiovascular Systems

Associations of Circulating Extracellular RNAs With Myocardial Remodeling and Heart Failure

Ravi Shah et al.

JAMA CARDIOLOGY (2018)

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Review Medicine, General & Internal

Circular RNAs: Promising Biomarkers for Human Diseases

Zhongrong Zhang et al.

EBIOMEDICINE (2018)

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Article Multidisciplinary Sciences

A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma

Maolei Zhang et al.

NATURE COMMUNICATIONS (2018)

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Article Multidisciplinary Sciences

Pan-cancer characterisation of microRNA across cancer hallmarks reveals microRNA-mediated downregulation of tumour suppressors

Andrew Dhawan et al.

NATURE COMMUNICATIONS (2018)

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Article Biotechnology & Applied Microbiology

A novel FLI1 exonic circular RNA promotes metastasis in breast cancer by coordinately regulating TET1 and DNMT1

Naifei Chen et al.

GENOME BIOLOGY (2018)

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Review Oncology

Non-coding RNA networks in cancer

Eleni Anastasiadou et al.

NATURE REVIEWS CANCER (2018)

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Article Biochemistry & Molecular Biology

Induction of tumor apoptosis through a circular RNA enhancing Foxo3 activity

William W. Du et al.

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Combining Anti-Mir-155 with Chemotherapy for the Treatment of Lung Cancers

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miR-718 represses proinflammatory cytokine production through targeting phosphatase and tensin homolog (PTEN)

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Antitumor immunity is defective in T cell-specific microRNA-155-deficient mice and is rescued by immune checkpoint blockade

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Safety and activity of microRNA-loaded minicells in patients with recurrent malignant pleural mesothelioma: a first-in-man, phase 1, open-label, dose-escalation study

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Exosome-Derived miR-25-3p and miR-92a-3p Stimulate Liposarcoma Progression

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N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration

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CircNet: a database of circular RNAs derived from transcriptome sequencing data

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CCAR1 5' UTR as a natural miRancer of miR-1254 overrides tamoxifen resistance

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Deregulation of microRNA-181c in cerebrospinal fluid of patients with clinically isolated syndrome is associated with early conversion to relapsing-remitting multiple sclerosis

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Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2

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Downregulated miR-506 expression facilitates pancreatic cancer progression and chemoresistance via SPHK1/Akt/NF-κB signaling

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Circulating microRNA signature for the diagnosis of very high-risk prostate cancer

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A peptide encoded by a transcript annotated as long noncoding RNA enhances SERCA activity in muscle

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Systematic discovery of cap-independent translation sequences in human and viral genomes

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Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs

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Reciprocal Changes of Circulating Long Non-Coding RNAs ZFAS1 and CDR1AS Predict Acute Myocardial Infarction

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Deregulation of microRNA-181c in cerebrospinal fluid of patients with clinically isolated syndrome is associated with early conversion to relapsing-remitting multiple sclerosis

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Assessment of Circulating LncRNAs Under Physiologic and Pathologic Conditions in Humans Reveals Potential Limitations as Biomarkers

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The miR-506-Induced Epithelial-Mesenchymal Transition is Involved in Poor Prognosis for Patients with Gastric Cancer

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Immune Checkpoint Blockade in Cancer Therapy

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The microRNA-212/132 cluster regulates B cell development by targeting Sox4

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Exosome-Mediated Transfer of microRNAs Within the Tumor Microenvironment and Neuroblastoma Resistance to Chemotherapy

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Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed

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The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3

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HOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer

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Exosome-Mediated Transfer of microRNAs Within the Tumor Microenvironment and Neuroblastoma Resistance to Chemotherapy

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MicroRNA silencing for cancer therapy targeted to the tumour microenvironment

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miR-155 augments CD8+ T-cell antitumor activity in lymphoreplete hosts by enhancing responsiveness to homeostatic γc cytokines

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Efficient backsplicing produces translatable circular mRNAs

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Human genetic variation and its effect on miRNA biogenesis, activity and function

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A phase 1 study of the BCL2-targeted deoxyribonucleic acid inhibitor (DNAi) PNT2258 in patients with advanced solid tumors

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Long Noncoding RNA TARID Directs Demethylation and Activation of the Tumor Suppressor TCF21 via GADD45A

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An Evolutionarily Conserved Long Noncoding RNA TUNA Controls Pluripotency and Neural Lineage Commitment

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Identification of differentially expressed microRNAs across the developing human brain

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The Long Non-Coding RNA GAS5 Cooperates with the Eukaryotic Translation Initiation Factor 4E to Regulate c-Myc Translation

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Transcriptomics identified a critical role for Th2 cell-intrinsic miR-155 in mediating allergy and antihelminth immunity

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Comparative RNA-sequencing analysis of myocardial and circulating small RNAs in human heart failure and their utility as biomarkers

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Cellular and Kaposi's sarcoma-associated herpes virus microRNAs in sepsis and surgical trauma

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HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer

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microRNAs are ligands of Toll-like receptors

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Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell Types

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MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response

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Re-polarization of tumor-associated macrophages to pro-inflammatory M1 macrophages by microRNA-155

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Long Noncoding RNA HOTAIR Regulates Polycomb-Dependent Chromatin Modification and Is Associated with Poor Prognosis in Colorectal Cancers

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The Association of MicroRNA Expression with Prognosis and Progression in Early-Stage, Non-Small Cell Lung Adenocarcinoma: A Retrospective Analysis of Three Cohorts

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Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses

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The Interleukin 13 (IL-13) Pathway in Human Macrophages Is Modulated by MicroRNA-155 via Direct Targeting of Interleukin 13 Receptor α1 (IL13Rα1)

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Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex

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Cell-free nucleic acids as biomarkers in cancer patients

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The MicroRNA Spectrum in 12 Body Fluids

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MicroRNA-155 Promotes Autoimmune Inflammation by Enhancing Inflammatory T Cell Development

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MicroRNA-34a Perturbs B Lymphocyte Development by Repressing the Forkhead Box Transcription Factor Foxp1

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MicroRNAs involvement in fludarabine refractory chronic lymphocytic leukemia

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Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis

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MicroRNAs: Target Recognition and Regulatory Functions

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Association of Inflammation-Related and microRNA Gene Expression with Cancer-Specific Mortality of Colon Adenocarcinoma

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Guidelines for the Evaluation of Immune Therapy Activity in Solid Tumors: Immune-Related Response Criteria

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MicroRNA: Implications for Alzheimer Disease and other Human CNS Disorders

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Foxp3-Dependent MicroRNA155 Confers Competitive Fitness to Regulatory T Cells by Targeting SOCS1 Protein

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MicroRNA Fingerprints Identify miR-150 as a Plasma Prognostic Marker in Patients with Sepsis

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Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma

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MicroRNA-10a binds the 5′UTR of ribosomal protein mRNAs and enhances their translation

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MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

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MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation

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MiR-15a and miR-16-1 cluster functions in human leukemia

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MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis

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RNA (2008)

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Switching from repression to activation: MicroRNAs can up-regulate translation

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MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

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MiR-150 controls B cell differentiation by targeting the transcription factor c-myb

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A cellular Micro-RNA, let-7i, regulates toll-like receptor 4 expression and contributes to cholangiocyte immune responses against Cryptosporidium parvum infection

Xian-Ming Chen et al.

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Ultraconserved regions encoding ncRNAs are, altered in human leukemias and carcinomas

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Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project

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Genome-wide transcription and the implications for genomic organization

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MicroRNA-133 controls cardiac hypertrophy

Alessandra Care et al.

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Control of stress-dependent cardiac growth and gene expression by a microRNA

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Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2

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CELL (2007)

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MicroRNAs play an essential role in the development of cardiac hypertrophy

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Cancer epigenomics: DNA methylomes and histone-modification maps

Manel Esteller

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MicroRNA signatures in human cancers

George A. Calin et al.

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microRNAs exhibit high frequency genomic alterations in human cancer

Lin Zhang et al.

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Modulation of hepatitis C virus RNA abundance by a liver-specific microRNA

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MicroRNA expression profiles classify human cancers

J Lu et al.

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MicroRNAs regulate brain morphogenesis in zebrafish

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Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets

BP Lewis et al.

CELL (2005)

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RNA regulation: a new genetics?

JS Mattick

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Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers

GA Calin et al.

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XIST unmethylated DNA fragments in male-derived plasma as a tumour marker for testicular cancer

T Kawakami et al.

LANCET (2004)

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Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia

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