Changes in the immune landscape of TNBC after neoadjuvant chemotherapy: correlation with relapse

Review Biochemistry & Molecular Biology

Triple-Negative Breast Cancer and Predictive Markers of Response to Neoadjuvant Chemotherapy: A Systematic Review

Nadine S. S. van den Ende et al.

Summary: Around 40-50% of TNBC patients achieve a pCR after neoadjuvant chemotherapy. Identification of baseline biomarkers predicting the response to NAC could aid in personalized treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Review Biology

Targets of Immune Escape Mechanisms in Cancer: Basis for Development and Evolution of Cancer Immune Checkpoint Inhibitors

Shovan Dutta et al.

Summary: Tumor immune escape mechanisms are major obstacles to successful cancer treatment. Despite host immunity, cancer cells can avoid detection and resistance from immune cell responses. New targets and strategies are crucial for efficacious immune responses. This review discusses classical immune checkpoint targets and explores emerging immunotherapeutic targets.

BIOLOGY-BASEL (2023)

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Article Multidisciplinary Sciences

Distinct spatial immune microlandscapes are independently associated with outcomes in triple-negative breast cancer

Jodi M. Carter et al.

Summary: The use of spatial immunobiomarker quantitation is being actively explored in the prognosis and prediction of therapy in triple-negative breast cancer (TNBC). In this study, high-plex quantitative digital spatial profiling was used to analyze the immune protein microenvironments in treatment-naive TNBC. The results show that immune protein profiles differ significantly in intraepithelial and adjacent stromal microenvironments, and the enrichment of certain immune proteins is associated with better outcomes, highlighting the importance of spatial microenvironments in predicting the prognosis of TNBC.

NATURE COMMUNICATIONS (2023)

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Article Respiratory System

Increased TIM-3 expression in tumor-associated macrophages predicts a poorer prognosis in non-small cell lung cancer: a retrospective cohort study

Chi Zhang et al.

Summary: This study evaluated the relationship between the expression of TIM-3 in tumor-associated macrophages and the clinical outcome of NSCLC patients. The findings showed that high TIM-3 expression was associated with higher CEA levels, lymph node metastasis, higher grade, and high CD68 and CD163 expression. It was also found to be an independent predictor of worse prognosis in patients. Therefore, TIM-3 expression may serve as a promising prognostic biomarker for NSCLC and adenocarcinoma.

JOURNAL OF THORACIC DISEASE (2023)

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Review Oncology

Multiomics technologies for comprehensive tumor microenvironment analysis in triple-negative breast cancer under neoadjuvant chemotherapy

Gang Wang et al.

Summary: Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype characterized by infiltrating immune cells in the tumor microenvironment (TME). Chemotherapy is the standard neoadjuvant treatment, but immune checkpoint inhibitors may enhance its efficacy. Traditional methods have limitations in analyzing the TME, but recent advances in high-throughput techniques, such as tissue imaging, cytometry, sequencing, and spatial omics, provide new insights. This review discusses these techniques and their potential application in clinical practice.

FRONTIERS IN ONCOLOGY (2023)

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Article Cell Biology

LYVE-1+macrophages form a collaborative CCR5-dependent perivascular niche that influences chemotherapy responses in murine breast cancer

Joanne E. Anstee et al.

Summary: This study describes a population of LYVE-1-expressing TAMs that form complex multi-cellular nest structures and are distributed around blood vessels in breast cancer tumors. The researchers found that LYVE-1+ TAMs develop in response to IL-6, and their nest formation is guided by a CCR5-dependent signaling axis. Blocking the development of LYVE-1+ TAMs or their nest structures enhances the recruitment of CD8+ T cells to the tumor and improves response to chemotherapy.

DEVELOPMENTAL CELL (2023)

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Review Oncology

Treatment landscape of triple-negative breast cancer - expanded options, evolving needs

Giampaolo Bianchini et al.

Summary: Recent advances in omics technologies have improved our understanding of the heterogeneity and microenvironment of triple-negative breast cancers (TNBCs), supporting a view of this breast cancer subtype as an ecosystem that encompasses both intrinsic and extrinsic features of cancer cells. The authors of this Review describe the current and upcoming therapeutic landscape of TNBC and discuss how an integrated view of the TNBC ecosystem can provide improved opportunities for tailoring treatment.

NATURE REVIEWS CLINICAL ONCOLOGY (2022)

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Article Biochemistry & Molecular Biology

Tissue-resident FOLR2+ macrophages associate with CD8+ T cell infiltration in human breast cancer

Rodrigo Nalio Ramos et al.

Summary: This study identifies a specific population of FOLR2(+) tissue-resident macrophages in healthy mammary gland and breast cancer primary tumors, which interact with CD8(+) T cells and positively correlate with better patient survival.

CELL (2022)

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Article Gastroenterology & Hepatology

TGF-β Alters the Proportion of Infiltrating Immune Cells in a Pancreatic Ductal Adenocarcinoma

Kasia Trebska-McGowan et al.

Summary: This study found that TGF-beta plays an important role in the anti-tumor immunity of pancreatic ductal adenocarcinoma (PDAC), but its effects on immune cells are context-dependent. TGF-beta mediates an overall immunosuppressive effect by increasing TAM PD-L1 expression and decreasing the presence of DCs.

JOURNAL OF GASTROINTESTINAL SURGERY (2022)

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Review Biochemistry & Molecular Biology

Molecular Mechanisms, Biomarkers and Emerging Therapies for Chemotherapy Resistant TNBC

Paola Ferrari et al.

Summary: Triple-negative breast cancer (TNBC) is associated with high recurrence rates, distant metastases, and poor survival. Taxane and anthracycline-containing chemotherapy are the main treatments for TNBC, but platinum-based chemotherapy has shown promising results. Chemoresistance is a common obstacle in TNBC treatment, and several mechanisms have been identified. Biomarkers can predict resistance to specific chemotherapeutic agents and may be used for personalized treatment in the future.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Oncology

Assessment of MRI to estimate metastatic dissemination risk and prometastatic effects of chemotherapy

George S. Karagiannis et al.

Summary: TMEM Activity-MRI is a novel method for detecting TMEM-associated vascular openings in the tumor microenvironment, which are important for cancer cell intravasation and metastatic dissemination. It correlates with primary tumor TMEM doorway counts and can be used in mechanistic studies of cancer cell dissemination and in assessing the effects of chemotherapy on TMEM doorway assembly.

NPJ BREAST CANCER (2022)

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Review Oncology

Adjuvant and Neoadjuvant Treatment of Triple-Negative Breast Cancer With Chemotherapy

Antonio Marra et al.

Summary: Triple-negative breast cancer lacks estrogen, progesterone receptors, and is more sensitive to chemotherapy. Neoadjuvant chemotherapy is the cornerstone of treatment, with anthracycline- and taxane-based regimens commonly used. Pathological complete response correlates strongly with long-term survival outcomes for early-stage TNBC patients.

CANCER JOURNAL (2021)

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Review Oncology

Immune checkpoint inhibitors plus neoadjuvant chemotherapy in early triple-negative breast cancer: a systematic review and meta-analysis

Yuanfang Xin et al.

Summary: The combination of PD-1/PD-L1 inhibitors with chemotherapy can improve pCR rates and EFS in early TNBC patients, but it also increases the risk of some immune-related adverse effects. This treatment option may be beneficial for patients with PD-L1 positive and high-risk populations with positive nodal disease early TNBC.

BMC CANCER (2021)

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Article Multidisciplinary Sciences

Multiplexed immunofluorescence identifies high stromal CD68+PD-L1+ macrophages as a predictor of improved survival in triple negative breast cancer

James Wang et al.

Summary: High CD68(+)PD-L1(+) expression is associated with improved overall survival and breast cancer-specific survival in TNBC patients, providing clinically useful prognostic information to identify sub-groups of patients with good or poor prognosis and guide treatment decisions.

SCIENTIFIC REPORTS (2021)

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Article Oncology

Unraveling Heterogeneity of Tumor Cells and Microenvironment and Its Clinical Implications for Triple Negative Breast Cancer

Ke Jiang et al.

Summary: This study systematically characterized the tumor heterogeneity of TNBC using single-cell RNA sequencing, revealing the existence of multiple immune cell types and their associations with clinical outcomes in TNBC tissues, particularly highlighting the significance of M2 macrophages and neutrophils.

FRONTIERS IN ONCOLOGY (2021)

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Article Immunology

Multi-Parameter Quantitative Imaging of Tumor Microenvironments Reveals Perivascular Immune Niches Associated With Anti-Tumor Immunity

Caleb R. Stoltzfus et al.

Summary: The complex localization patterns and distinct tumor microenvironments of immune cells within tumors play a critical role in disease outcome and therapeutic response. CEA-TCB immunotherapy enhances intra-tumoral CD8 T cell abundance and generates specific perivascular immune niches, potentially affecting treatment outcomes.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Biochemistry & Molecular Biology

Survival analysis across the entire transcriptome identifies biomarkers with the highest prognostic power in breast cancer

Balazs Gyorffy

Summary: This study presents a ranking of all survival-related genes in chemotherapy treated basal and estrogen positive/HER2 negative breast cancer, providing a reference for future biomarker research. By analyzing hazard rates and p values of genes, the most promising prognostic genes can be identified, helping to focus research on candidates with the most clinical significance.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2021)

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Article Oncology

Tumor-associated macrophages are associated with response to neoadjuvant chemotherapy and poor outcomes in patients with triple-negative breast cancer

Jia-hui Ye et al.

Summary: The study revealed that the infiltration level of CD163(+) macrophages was closely associated with chemotherapeutic response and survival rate in TNBC patients, indicating that TAMs may serve as predictive indicators for NAC treatment and potential prognostic markers for poor survival in TNBC patients.

JOURNAL OF CANCER (2021)

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Article Biochemistry & Molecular Biology

Stromal cell diversity associated with immune evasion in human triple-negative breast cancer

Sunny Z. Wu et al.

EMBO JOURNAL (2020)

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Review Biochemistry & Molecular Biology

Regulatory T cells in tumor microenvironment: new mechanisms, potential therapeutic strategies and future prospects

Chunxiao Li et al.

MOLECULAR CANCER (2020)

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Article Biochemistry & Molecular Biology

Onco-fetal Reprogramming of Endothelial Cells Drives Immunosuppressive Macrophages in Hepatocellular Carcinoma

Ankur Sharma et al.

CELL (2020)

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Article Medicine, General & Internal

Pembrolizumab plus chemotherapy versus placebo plus chemotherapy for previously untreated locally recurrent inoperable or metastatic triple-negative breast cancer (KEYNOTE-355): a randomised, placebo-controlled, double-blind, phase 3 clinical trial

Javier Cortes et al.

LANCET (2020)

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Review Immunology

Tumor-Derived Myeloid Cell Chemoattractants and T Cell Exclusion in Pancreatic Cancer

Robert H. Vonderheide et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Medicine, Research & Experimental

Spatially distinct tumor immune microenvironments stratify triple-negative breast cancers

Tina Gruosso et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

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Article Oncology

Poor Response to Neoadjuvant Chemotherapy Correlates with Mast Cell Infiltration in Inflammatory Breast Cancer

Sangeetha M. Reddy et al.

CANCER IMMUNOLOGY RESEARCH (2019)

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Article Biochemistry & Molecular Biology

Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment

Elham Azizi et al.

CELL (2018)

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Article Oncology

Tumour-infiltrating lymphocytes and prognosis in different subtypes of breast cancer: a pooled analysis of 3771 patients treated with neoadjuvant therapy

Carsten Denkert et al.

LANCET ONCOLOGY (2018)

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Article Multidisciplinary Sciences

Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti-PD-1 treatment

Elisa Peranzoni et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

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Article Cell Biology

A Unidirectional Transition from Migratory to Perivascular Macrophage Is Required for Tumor Cell Intravasation

Esther N. Arwert et al.

CELL REPORTS (2018)

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Article Biochemistry & Molecular Biology

A Structured Tumor-Immune Microenvironment in Triple Negative Breast Cancer Revealed by Multiplexed Ion Beam Imaging

Leeat Keren et al.

CELL (2018)

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Article Oncology

Perivascular Tumor-Infiltrating Leukocyte Scoring for Prognosis of Resected Hepatocellular Carcinoma Patients

Markus Bo Schoenberg et al.

CANCERS (2018)

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Review Immunology

Perivascular macrophages in health and disease

Antonio Lapenna et al.

NATURE REVIEWS IMMUNOLOGY (2018)

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Article Oncology

T-Cell Immunoglobulin Mucin 3 Expression on Tumor Infiltrating Lymphocytes as a Positive Prognosticator in Triple-Negative Breast Cancer

Kyung Do Byun et al.

JOURNAL OF BREAST CANCER (2018)

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Article Cell Biology

Neoadjuvant chemotherapy induces breast cancer metastasis through a TMEM-mediated mechanism

George S. Karagiannis et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

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Article Multidisciplinary Sciences

Single-cell RNA-seq enables comprehensive tumour and immune cell profiling in primary breast cancer

Woosung Chung et al.

NATURE COMMUNICATIONS (2017)

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Article Immunology

CD4+and Perivascular Foxp3+T Cells in Glioma Correlate with Angiogenesis and Tumor Progression

Luyan Mu et al.

FRONTIERS IN IMMUNOLOGY (2017)

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Article Cell Biology

Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer

Shicheng Su et al.

CELL RESEARCH (2017)

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Correction Oncology

The Multifaceted Role of Perivascular Macrophages in Tumors (vol 30, pg 18, 2016)

Claire E. Lewis et al.

CANCER CELL (2016)

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Article Oncology

Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy

Russell Hughes et al.

CANCER RESEARCH (2015)

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Article Gastroenterology & Hepatology

Tim-3 fosters HCC development by enhancing TGF-β-mediated alternative activation of macrophages

Wenjiang Yan et al.

GUT (2015)

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Article Oncology

The Coordinated Actions of TIM-3 on Cancer and Myeloid Cells in the Regulation of Tumorigenicity and Clinical Prognosis in Clear Cell Renal Cell Carcinomas

Yoshihiro Komohara et al.

CANCER IMMUNOLOGY RESEARCH (2015)

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Article Medicine, Research & Experimental

TGF-β inhibition enhances chemotherapy action against triple-negative breast cancer

Neil E. Bhola et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

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Highly multiplexed single-cell analysis of formalin-fixed, paraffin-embedded cancer tissue

Michael J. Gerdes et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

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Immunotype and Immunohistologic Characteristics of Tumor-Infiltrating Immune Cells Are Associated with Clinical Outcome in Metastatic Melanoma

Gulsun Erdag et al.

CANCER RESEARCH (2012)

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Article Multidisciplinary Sciences

Leukocyte composition of human breast cancer

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

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Angiopoietin 2 Stimulates TIE2-Expressing Monocytes To Suppress T Cell Activation and To Promote Regulatory T Cell Expansion

Seth B. Coffelt et al.

JOURNAL OF IMMUNOLOGY (2011)

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Article Surgery

Interferon-gamma induces PD-L1 expression in macrophages and neutrophils

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JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS (2011)

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Changes in the immune landscape of TNBC after neoadjuvant chemotherapy: correlation with relapse

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