Journal
CHEMICAL COMMUNICATIONS
Volume -, Issue -, Pages -Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d3cc04725c
Keywords
-
Categories
Ask authors/readers for more resources
The search for solid solutions of class-two insulin secretagogues tolbutamide and chlorpropamide reveals a rare case of monotropic polymorphism for the mixed crystals. The solid solutions exhibit superior solubility advantage over pure drugs, suggesting potential applications as highly soluble co-drug formulations.
The search for solid solutions of class-two insulin secretagogues, tolbutamide and chlorpropamide, reveals a rare case of monotropic polymorphism for the mixed crystals. At any stoichiometry, two crystal forms are isolated that are kinetically stable at room temperature from a few months to over a year. Dissolution tests certify the solubility advantage of the solid solutions over the pure drugs as well as their physical mixture, suggesting a potential application as a highly soluble co-drug formulation. Tolbutamide and chloropropamide form two co-drug solid solutions that show a rare case of monotropic polymorphism at any composition. Both forms are kinetically stable and with faster dissolution rate than the pure drugs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available