Journal
JOURNAL OF MOLECULAR LIQUIDS
Volume 391, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.molliq.2023.123285
Keywords
Bovine serum albumin; Human serum albumin; Dynamic surface tension; Equilibrium surface tension; Dilational modulus; Globular protein
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The dynamic and equilibrium surface tensions of Human Serum Albumin (HSA) and Bovine Serum Albumin (BSA) solutions were compared in this study, along with the dilational modulus of the adsorbed films. The results showed that HSA had a faster relaxation in dynamic surface tension compared to BSA, while the equilibrium surface tension remained constant for both HSA and BSA at different concentrations. The dilational modulus of the films exhibited similar concentration dependency for HSA and BSA.
The biological functionalities of Human Serum Albumin (HSA) and Bovine Serum Albumin (BSA) have been extensively studied in the literature. However, limited information is available on their surface properties [dy-namic/equilibrium surface tension (ST) and dilational modulus (E)]. This study compared the dynamic/equi-librium ST of HSA and BSA solutions and the E of the adsorbed films. A pendant bubble tensiometer was employed for measuring the relaxations of ST of HSA/BSA solutions at C = 0.01 - 90 (10-10 mol/cm3). The data revealed that while the dynamic ST of HSA(aq) and BSA(aq) exhibited a similar relaxation in general, the ST of HSA(aq) relaxed notably faster at the post-induction regime than BSA(aq). The equilibrium ST of both HSA and BSA was constant at 52.6 and 52.3 mN/m over a wide concentration range, C = 0.01 - 90 (10-10 mol/cm3). The E of HSA and BSA films exhibited a near-identical concentration dependency to each other: E was reasonably constant at -21 mN/m from C = 0.05 to 0.2 (10-10 mol/cm3), and at further concentration elevations, E rose notably, and eventually leveled off at -52 and -45 mN/m for HSA and BSA films, respectively.
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