USP4 promotes the proliferation, migration, and invasion of esophageal squamous cell carcinoma by targeting TAK1

Article Oncology

High expression of PPFIA1 in human esophageal squamous cell carcinoma correlates with tumor metastasis and poor prognosis

Yongyin Gao et al.

Summary: The expression of PPFIA1 is increased in ESCC and is associated with worse prognosis. PPFIA1 may serve as a potential biomarker for evaluating the prognosis of ESCC patients.

BMC CANCER (2023)

Add to Collection

Article Oncology

CXCR4 promotes the growth and metastasis of esophageal squamous cell carcinoma as a critical downstream mediator of HIF-1 alpha

Xianxian Wu et al.

Summary: CXCR4, a member of the CXC chemokine receptor family, plays a crucial role in esophageal squamous cell carcinoma (ESCC) by promoting cancer cell proliferation, migration, invasion, and survival. HIF-1α transcriptionally regulates CXCR4 expression, indicating the potential of CXCR4 as a therapeutic target for ESCC.

CANCER SCIENCE (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Therapeutic target database update 2022: facilitating drug discovery with enriched comparative data of targeted agents

Ying Zhou et al.

Summary: Drug discovery relies not only on knowledge of drugs and targets, but also on understanding comparative agents and targets. This study introduces a major update to the Therapeutic Target Database, providing valuable data on poor binders, non-binders, prodrug-drug pairs, co-targets, and drug-like properties, as well as additional features for advanced search and cross-links to target structures. The database is accessible without login requirement at: https://idrblab.org/ttd/.

NUCLEIC ACIDS RESEARCH (2022)

Add to Collection

Article Cell Biology

USP15 and USP4 facilitate lung cancer cell proliferation by regulating the alternative splicing of SRSF1

Tanuza Das et al.

Summary: The deubiquitinating enzyme USP15 and its close paralog USP4 regulate the alternative splicing of SRSF1, promoting lung cancer cell proliferation. The depletion of USP15 and USP4 leads to impairment of SRSF1 splicing, resulting in an alternative isoform SRSF1-3. The increased expression of USP15 contributes to the development of lung adenocarcinoma and is associated with lower disease-specific survival in patients.

CELL DEATH DISCOVERY (2022)

Add to Collection

Article Cell Biology

USP15 negatively regulates lung cancer progression through the TRAF6-BECN1 signaling axis for autophagy induction

Mi-Jeong Kim et al.

Summary: The study reveals that USP15 is significantly downregulated in lung cancer patients, and its knockout leads to increased migration, invasion, and autophagy induction in lung cancer cells. USP15 interacts with BECN1 and deubiquitinates it, thereby attenuating autophagy induction. Additionally, the expression of USP15 is associated with the upregulation of certain oncogenes and downregulation of tumor suppressor genes in lung cancer patients.

CELL DEATH & DISEASE (2022)

Add to Collection

Article Environmental Sciences

LOXL3-promoted hepatocellular carcinoma progression via promotion of Snail1/USP4-mediated epithelial-mesenchymal transition

Rong Li et al.

Summary: The study found that high expression of LOXL3 in HCC was significantly correlated with tumor size and clinical stage, predicting a poor prognosis. Experimental results demonstrated that LOXL3 promoted HCC EMT process through the Snail1/USP4-mediated circulation loop and Wnt/β-catenin signaling pathway.

ENVIRONMENTAL TOXICOLOGY (2022)

Add to Collection

Article Gastroenterology & Hepatology

The Global Landscape of Esophageal Squamous Cell Carcinoma and Esophageal Adenocarcinoma Incidence and Mortality in 2020 and Projections to 2040: New Estimates From GLOBOCAN 2020

Eileen Morgan et al.

Summary: This study provides an overview of the burden of esophageal cancer in 185 countries in the year 2020 and projections for 2040. The global incidence and mortality rates of esophageal cancer vary across countries and regions, with higher rates observed in males compared to females. The predicted burden in 2040 shows an increase in new cases and deaths from esophageal cancer.

GASTROENTEROLOGY (2022)

Add to Collection

Article Immunology

Transcriptome Analysis and Single-Cell Sequencing Analysis Constructed the Ubiquitination-Related Signature in Glioma and Identified USP4 as a Novel Biomarker

Qikai Tang et al.

Summary: This study investigates the role of ubiquitination genes in gliomas and identifies USP4 as a potential biomarker for glioma. The findings suggest that this research provides new insights for the treatment and immunotherapy of glioma.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection

Article Cell Biology

WNT5A promotes the metastasis of esophageal squamous cell carcinoma by activating the HDAC7/SNAIL signaling pathway

Yingtong Feng et al.

Summary: This study found that the expression of WNT5A and SNAIL was significantly increased in esophageal squamous cell carcinoma (ESCC), and correlated positively with lymphatic metastasis and poor prognosis. Further investigation revealed that WNT5A could induce the epithelial-mesenchymal transition and promote ESCC cell metastasis through upregulating HDAC7 expression. Therefore, targeting WNT5A and HDAC7 might be potential therapeutic strategies for ESCC.

CELL DEATH & DISEASE (2022)

Add to Collection

Article Medicine, Research & Experimental

SOX2-Upregulated microRNA-30e Promotes the Progression of Esophageal Cancer via Regulation of the USP4/SMAD4/CK2 AxisS

Yang Yang et al.

Summary: This study reveals that SOX2 promotes the proliferation, invasion, and migration of esophageal cancer cells by regulating the miR-30e/USP4/SMAD4/CK2 axis, serving as a potential target for the treatment of EC.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

Add to Collection

Article Oncology

Preoperative pembrolizumab combined with chemoradiotherapy for oesophageal squamous cell carcinoma (PALACE-1)

Chengqiang Li et al.

Summary: This study investigated the safety and efficacy of preoperative pembrolizumab combined with chemoradiotherapy in resectable oesophageal squamous cell carcinoma patients. The results showed that this treatment was safe and induced a pathological complete response in 55.6% of the tumors.

EUROPEAN JOURNAL OF CANCER (2021)

Add to Collection

Review Pharmacology & Pharmacy

Advances and challenges in the treatment of esophageal cancer

Shiming He et al.

Summary: Esophageal cancer is a common and deadly cancer with two histological subtypes - esophageal squamous cell carcinoma and esophageal adenocarcinoma. Available treatment strategies include surgery, chemotherapy, and molecular targeted therapy, with poor prognosis. This review discusses the latest developments in chemotherapy, molecular targeted therapy, and immunotherapy for esophageal cancer.

ACTA PHARMACEUTICA SINICA B (2021)

Add to Collection

Review Cell Biology

Spotlight on USP4: Structure, Function, and Regulation

Binbin Hu et al.

Summary: USP4 is a critical deubiquitinating enzyme involved in regulating the balance of protein synthesis and degradation, sharing a common domain organization with its paralogs USP11 and USP15. It plays a crucial role in normal physiological conditions and aberrant expression or activity of USP4 is implicated in the progression of various pathologies, especially cancers. Effective therapeutic interventions targeting USP4 are important for potential treatment strategies.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Add to Collection

Article Medicine, General & Internal

High-mobility group AT-hook 2 promotes growth and metastasis and is regulated by miR-204-5p in oesophageal squamous cell carcinoma

Hongdian Zhang et al.

Summary: The study showed that HMGA2 is upregulated and miR-204-5p is downregulated in ESCC. HMGA2 expression is correlated with tumor characteristics and serves as an independent prognostic factor. The negative correlation between HMGA2 and miR-204-5p suggests that HMGA2 functions as an oncogene in ESCC, which is negatively regulated by miR-204-5p.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2021)

Add to Collection

Article Surgery

Long-term Efficacy of Neoadjuvant Chemoradiotherapy Plus Surgery for the Treatment of Locally Advanced Esophageal Squamous Cell Carcinoma The NEOCRTEC5010 Randomized Clinical Trial

Hong Yang et al.

Summary: The study found that neoadjuvant chemoradiotherapy (NCRT) followed by surgery significantly improved long-term overall survival and disease-free survival in patients with locally advanced esophageal squamous cell carcinoma (ESCC).

JAMA SURGERY (2021)

Add to Collection

Article Oncology