Journal
MATERIALS TODAY BIO
Volume 23, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.mtbio.2023.100798
Keywords
Poly(glycerol sebacate); Fibrous scaffolds; Mechanical and electrical properties; Cardiac tissue engineering
Ask authors/readers for more resources
In this study, a novel biocompatible fibrous scaffold with tunable mechanical and electrical properties was successfully prepared by blending PGS and PANI materials. These scaffolds promote cell adhesion and proliferation, exhibit good biocompatibility and hemocompatibility, and have great potential for cardiac tissue engineering.
Biomaterial tissue engineering scaffolds play a critical role in providing mechanical support, promoting cells growth and proliferation. However, due to the insulation and inappropriate stiffness of most biomaterials, there is an unmet need to engineer a biomimetic nanofibrous cardiac tissue engineering scaffold with tailorable mechanical and electrical properties. Here, we demonstrate for the first time the feasibility to generate a novel type of biocompatible fibrous scaffolds by blending elastic poly(glycerol sebacate) (PGS) and conductive polyaniline (PANI) with the help of a nontoxic carrier polymer, poly (vinyl alcohol) (PVA). Aligned and random PGS/PANI scaffolds are successfully obtained after electrospinning, cross-linking, water and ethanol wash. Incorporating of different concentrations of PANI into PGS fibers, the fibrous sheets show enhanced conductivity and slower degradation rates while maintaining the favorable hemocompatibility. The elastic modulus of the PGS/PANI scaffolds is in the range of 0.65-2.18 MPa under wet conditions, which is similar to that of natural myocardium. All of these fibrous mats show good cell viability and were able to promote adhesion and proliferation of H9c2 cells. Furthermore, the in vivo host responses of both random and aligned scaffolds confirm their good biocompatibility. Therefore, these PGS/PANI scaffolds have great potential for cardiac tissue engineering.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available