Journal
ASIAN JOURNAL OF ORGANIC CHEMISTRY
Volume 5, Issue 11, Pages 1323-1326Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ajoc.201600358
Keywords
asymmetric hydrogenation; chiral aminophosphine ligand; chiral non-precious metal catalysts; cobalt complex; ketones
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Funding
- National Natural Science Foundation of China [21173176, 21502158]
- Program for Innovative Research Team in Chinese Universities [IRT_14R31]
- Fundamental Research Funds for the Central Universities [20720150040]
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Novel chiral cobalt complexes containing a PNNP-type ligand were synthesized using a straightforward method. The structures of the cobalt complexes have been fully characterized by X-ray crystallography, high resolution mass spectrometry (HRMS), and electron paramagnetic resonance (EPR). Using H-2 as the hydrogen source, the cobalt-catalyzed asymmetric hydrogenation of various ketones was investigated, and the corresponding chiral alcohols were afforded with up to 99% yield and 95% ee. To the best of our knowledge, this is the first example of a cobalt-catalyzed enantioselective hydrogenation of ketones with molecular hydrogen.
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