Journal
ASIAN JOURNAL OF ORGANIC CHEMISTRY
Volume 5, Issue 11, Pages 1345-1352Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ajoc.201600321
Keywords
benzofurans; copper; mechanistic studies; natural products; tandem reactions
Categories
Funding
- Fundamental Research Funds for the Central Universities [20720160047]
- NSFC [21273187, 21133004]
Ask authors/readers for more resources
An asymmetric dinuclear copper(I) complex, Cu-2(I)(pip)(2) (pip=(2-picolyliminomethyl)pyrrole anion), was used to catalyze the tandem coupling/cyclization reaction of o-iodophenols and terminal alkynes, which led to the formation of valuable 2-arylbenzofurans in good yields. DFT calculations showed that the two proximate copper atoms play cooperative roles throughout the catalytic cycle. Using this catalytic protocol, bioactive natural products stemofuran A and moracin M were concisely synthesized.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available