Journal
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
Volume 45, Issue 4, Pages 833-842Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/21691401.2016.1178134
Keywords
Biocompatibility; blood brain barrier; immune response; nanomaterials; polymer; toxicity
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Funding
- Tehran University of Medical Sciences
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There has been huge interest in applications of nanomaterials in biomedical science, including diagnosis, drug delivery, and development of human organs. Number of these nanomaterials has been already studied in human or at pre-clinical trial. There is a growing concern on potential toxicity and adverse effects of nanomaterials on human health, including lack of standard method of assessment of toxicology of these materials. Our investigation indicated that the bare and small nanoparticle have higher toxicity than modified and bulk materials, respectively. In addition, spherical nanoparticles have less toxicity than rod nanoparticles due to immune response of body.
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