Journal
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
Volume 45, Issue 7, Pages 1255-1271Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/21691401.2016.1246452
Keywords
Stemness; MSCs; regenerative medicine; differentiation
Categories
Funding
- Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran [94/2-1/2]
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Recent evidence suggests that mesenchymal stem cells (MSCs) have promising therapeutic potential for a broad range of diseases. Because the percentage of MSCs obtained from tissues is very low for cell therapy applications, ex vivo expansion of MSCs is necessary, but aging, loss of stemness and undesired differentiation of them during in vitro cultivation reduces their effectiveness. For achieving ideal therapeutic potential of MSCs in tissue regenerative purposes, it is necessary to retain their stemness properties in vitro. This review emphasis on the last updates in preserving the self-renewal capability of stem cells through in vitro expansion with different parameters.
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