The role of Wnt signaling in mesenchymal stromal cell-driven angiogenesis

Development, growth, and remodeling of blood vessels occur through an intricate process involving cell differentiation, proliferation, and rearrangement by cell migration under the direction of various signaling pathways. Recent reports highlight that resident and exogenous mesenchymal stromal cells (MSCs) have the potential to regulate the neovascularization process through paracrine secretion of proangiogenic factors. Recent research has established that the vasculogenic potential of MSCs is regulated by several signaling pathways, including the Wnt signaling pathway, and their interplay. These findings emphasize the complex nature of the vasculogenic process and underscore the importance of understanding the underlying molecular mechanisms for the development of effective cell-based therapies in regenerative medicine. This review provides an updated briefing on the canonical and non-canonical Wnt signaling pathways and summarizes the recent reports of both in vitro and in vivo studies with the involvement of MSCs of various sources in the vasculogenic process mediated by Wnt signaling pathways. Here we outline the current understanding of the plausible role of the Wnt signaling pathway, specifically in MSC-regulated angiogenesis

Automated summary

This passage introduces the complex process of blood vessel development, growth, and remodeling, as well as the signaling pathways involved in this process. It highlights the potential of resident and exogenous mesenchymal stromal cells (MSCs) to regulate neovascularization through the secretion of proangiogenic factors. The review provides an updated overview of the canonical and non-canonical Wnt signaling pathways, as well as recent studies on MSCs' involvement in vasculogenic processes mediated by Wnt signaling pathways.