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Summary: This review on osteoarthritis biology summarizes a series of research articles published between the 2020 and 2021 Osteoarthritis Research Society International (OARSI) World Congress. It focuses on the new discoveries of osteoarthritis's cellular molecular mechanism, anatomical signatures, potential therapeutic targets, and regenerative therapy. The review highlights the recently developed potential therapeutic targets, such as TGF13 and Wnt signaling, and discusses their roles in joint tissue homeostasis, joint aging, and cartilage homeostasis. It also introduces new anatomical structures and osteoarthritis features and discusses the possibility of tissue regeneration in osteoarthritis joints. Lastly, it discusses the clinical evidence of the importance of delivery site of bone marrow stem cells for osteoarthritis treatment.

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