Journal
CELL AND BIOSCIENCE
Volume 13, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s13578-023-01170-9
Keywords
Primary biliary cholangitis; Genetically modified models; Chemically inducible models; Biologically inducible models; Challenges
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This article reviews the recent progress in PBC animal models, highlighting their limitations and connection with clinical practice.
BackgroundPrimary biliary cholangitis (PBC) is an autoimmune liver disease. The aetiology of PBC remains unclear, and its pathogenesis is complex. Animal models are essential to clarify the pathogenesis of PBC and explore the occurrence of early events.Main bodyHerein, we review recent research progress in PBC animal models, including genetically modified, chemically inducible, biologically inducible, and protein-immunised models. Although these animal models exhibit several immunological and pathological features of PBC, they all have limitations that constrain further research and weaken their connection with clinical practice.ConclusionThe review will benefit efforts to understand and optimise animal models in order to further clarify PBC pathogenesis and molecular targets for therapeutic interventions.
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