Development of europium(III) complex fluorescent probe for hydrogen sulfide detection and its application in water samples

Article Multidisciplinary Sciences

CBS-H2S axis preserves the intestinal barrier function by inhibiting COX-2 through sulfhydrating human antigen R in colitis

Shihao Guo et al.

Summary: The CBS-H2S axis plays a significant role in protecting the intestinal barrier in colitis. It increases the sulfhydration level of HuR, which reduces the binding of HuR with COX-2 mRNA and inhibits COX-2 expression.

JOURNAL OF ADVANCED RESEARCH (2023)

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Article Chemistry, Inorganic & Nuclear

Development of an Organic Dye-Conjugated β-Diketonate-Europium Complex Luminescence Probe for Discrimination and Detection of Intracellular Biothiols

Xiao Meng et al.

Summary: In this study, an organic dye-conjugated beta-diketonate-Eu3+ complex was developed as a luminescent probe for detecting and discriminating biothiols. The complex emits long-lived red emission upon reaction with biothiols and also generates different luminescent derivatives. This probe allows for quantitative detection and discrimination of GSH and Cys/Hcy.

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY (2023)

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Article Immunology

Hydrogen Sulfide Promotes Osteogenesis by Modulating Macrophage Polarization

Tianjian Zhou et al.

Summary: Hydrogen sulfide promotes M2 polarization of macrophages and subsequently enhances bone regeneration. The H2S-donor GYY4137 stimulates M0/M1 macrophages to express CD-206 and IL-10 while reducing the levels of i-NOS and TNF-alpha in M1 macrophages. Furthermore, co-culture with GYY4137-treated M0 macrophages increases the viability and mineralized particle formation of MC3T3-E1 cells.

INTERNATIONAL IMMUNOPHARMACOLOGY (2023)

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Article Agriculture, Multidisciplinary

Novel 2-Benzo[d]thiazolyl-4-quinolinylphenol Skeleton-Based Turn- on Fluorescent Probe for H2S Detection and its Multiple Applications in Water Environment, Foodstuffs, and Living Organisms

Mingxin Li et al.

Summary: Hydrogen sulfide (H2S) plays a vital role in maintaining organism functioning and stability, but it can also be found in wastewater and affect food quality. Therefore, the development of sensitive detection techniques for tracing H2S is important. A novel fluorescent probe NPS was designed and synthesized, which showed excellent sensitivity, low detection limit (79 nM), good selectivity, and wide pH range (5-9). NPS emitted strong yellow fluorescence upon the presence of H2S, and its recognition mechanism was verified through various analyses. Furthermore, NPS demonstrated potential applications in monitoring water samples, wine, beer, eggs, and bioimaging in living cells and zebrafish, showcasing its versatility and value in environmental and food quality analysis.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2023)

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Article Agriculture, Multidisciplinary

Dual-Responsive Benzo-Hemicyanine-Based Fluorescent Probe for Detection of Cyanide and Hydrogen Sulfide: Real-Time Application in Identification of Food Spoilage

Kuppan Magesh et al.

Summary: A dual-approachable red-emitting fluorescent probe PBiSMe was synthesized for rapid detection of CN- and HS-. The probe exhibited high detection limits and good quantum yield, and could be applied for detecting H2S gas produced by food spoilage and fluorescence bioimaging of living cells.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2023)

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Article Biochemical Research Methods

Monitoring hydrogen sulfide de-novo formation from polysulfides present in wine using ion chromatography and ultra high-pressure liquid chromatography combined with fraction collection and high-resolution mass spectrometry

Susanne Dekker et al.

Summary: The study developed a method to investigate the degradation of a single polysulfide and the formation of H2S using ultra-high pressure liquid chromatography and high resolution mass spectrometry. The method allowed for the observation of different polysulfides and the release of H2S originating from a target compound. This research demonstrates promising applications for polysulfide studies and contributes to the understanding of polysulfide chemistry in wine.

JOURNAL OF CHROMATOGRAPHY A (2023)

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Article Biochemistry & Molecular Biology

Development of novel hydrogen sulfide depletion aided platform for photodynamic therapy with enhanced anticancer performance

Fang Jia et al.

Summary: This study presents a H2S depletion aided photodynamic therapy (PDT) platform that can effectively kill cancer cells through in situ irradiation. The platform also exhibits prominent anticancer effects in tumor-bearing mice without notable toxic side effects.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY (2023)

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Article Chemistry, Applied

An off- on NIR fluorescence probe for visualization of H2S in food spoilage, living cells and zebrafish

Haibo Liu et al.

Summary: Researchers have developed a simple hydrogen sulfide-activatable fluorescence probe that can selectively detect H2S in food samples and biological systems. The probe shows a remarkable near-infrared (NIR) fluorescence response with a low limit of detection, and is capable of successfully detecting H2S in food spoilage and living cells with excellent biocompatibility.

DYES AND PIGMENTS (2023)

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Article Chemistry, Applied

Mitochondria-targeted fluorescent probe with long wavelength emission for detecting H2S and its application in foodstuff, water and living cells

Ling Xie et al.

Summary: In this study, a unique mitochondria-targeting fluorescence probe (DDMI) was established for the determination of H2S in living cells. The probe showed significant fluorescence enhancement at 623 nm when treated with H2S, and exhibited good selectivity and high sensitivity. It could also detect H2S in water samples with good recoveries and track the degree of food spoilage. Furthermore, the probe was successfully used for monitoring exogenous H2S in living cells and mitochondria targeting.

FOOD CHEMISTRY (2023)

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Article Chemistry, Analytical

Rapid and reversible detection of trace amounts of H2S in air and packaged food using a biogenic bismuth oxide nanorod colorimetric sensor

Monica Jaiswal et al.

SENSORS AND ACTUATORS B-CHEMICAL (2023)

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Article Spectroscopy

A bio-friendly biotin-coupled and azide-functionalized naphthalimide for real-time endogenous hydrogen sulfide analysis in living cells

Yujin Cha et al.

Summary: In this study, a bio-friendly biotin-coupled and azide-functionalized naphthalimide (1) was developed as a fluorescent probe for real-time analysis of hydrogen sulfide (H2S) in living systems. The probe selectively provided fluorescence at 545 nm via H2S-mediated azide reduction, without interference from biologically abundant constituents and pH effects. In biological studies using A549 cells, the probe easily penetrated living cells without toxicity, and unreacted probes showed minimal fluorescence, enabling real-time detection of H2S without the need for separate washing processes.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2023)

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Article Chemistry, Applied

Highly selective near-infrared fluorescent probe with large Stokes shift and sensitivity for H2S detection in water, foodstuff and imaging in living cells

Ling Xie et al.

Summary: In this study, a novel near-infrared fluorescent probe was synthesized for the selective detection of H2S. The probe showed excellent characteristics such as fluorescence intensity emission change, high selectivity, and outstanding performance in food quality and water sample monitoring.

DYES AND PIGMENTS (2023)

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Article Chemistry, Physical

Design and application: A ordered dual-locked fluorescence probe for hydrogen sulfide specific reaction and lipid droplets-targeted

Ying Liu et al.

Summary: Researchers developed a novel fluorescence probe (TBAF-NBD) to accurately detect hydrogen sulfide (H2S) and lipid droplets (LDs) in cancer and inflammation. The probe released TBAF-OH upon reacting with H2S, which targeted LDs and emitted strong fluorescence. The method showed high sensitivity with a linear range of 0.5-18 μM and a detection limit of 0.09 μM, and was successfully applied in imaging H2S in cancer cells, inflammatory cells, and zebrafish, demonstrating its potential in accurate disease diagnosis.

JOURNAL OF MOLECULAR STRUCTURE (2023)

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Article Chemistry, Physical

Engineering a mitochondria-targeted fluorescent probe with long wavelength for rapid detection of H2S in beer, water and living cells

Ling Xie et al.

Summary: In this study, a novel fluorescent probe HMTI was designed and synthesized for the discrimination of H2S. The probe showed fast response, low limit of detection and excellent ability of specific recognition, making it applicable for monitoring H2S in the environment, food and living cells.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY (2023)

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Article Engineering, Environmental

Sequential detection of H2S and HOBr with a novel lysosome-targetable fluorescent probe and its application in biological imaging

Shuai Mu et al.

Summary: This study presents the design and synthesis of a sequential responsive probe for detecting H2S and HOBr within lysosomes in living cells, demonstrating high selectivity and sensitivity. The probe was successfully utilized to observe the metabolic interactions of H2S and HOBr in cells.

JOURNAL OF HAZARDOUS MATERIALS (2022)

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Article Chemistry, Analytical

Monitoring the fluctuation of H2S in insulin-resistant HepG2 cells and diabetic mice with a dual-locked NIR fluorescent probe

Zimeng Li et al.

Summary: In this study, a dual-locked near-infrared fluorescent probe was developed for monitoring the fluctuation of H2S in vitro and in vivo. The probe showed high selectivity and sensitivity to H2S compared to single-locked probes. Using this probe, visualization of endogenous H2S production in insulin-resistant cells and the fluctuation of H2S in diabetic mice was achieved for the first time.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

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Article Chemistry, Analytical

A fluorescent Rhodol-derived probe for rapid and selective detection of hydrogen sulfide and its application

Meng-Ya Guo et al.

Summary: A novel fluorescent probe, Rho-HS, was developed for detecting H2S with wide pH range, rapid response, high selectivity, and low cytotoxicity. It was successfully applied in biological imaging.

TALANTA (2022)

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Article Multidisciplinary Sciences

H2S donating corticosteroids: Design, synthesis and biological evaluation in a murine model of asthma

Angela Corvino et al.

Summary: The study focuses on the design and synthesis of molecular hybrids capable of releasing hydrogen sulfide, with the Prednisone-TBZ hybrid showing promising anti-inflammatory properties in reducing allergic asthma symptoms and exacerbations.

JOURNAL OF ADVANCED RESEARCH (2022)

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Article Chemistry, Analytical

Near-Infrared Fluorescent Probe with Large Stokes Shift for Imaging of Hydrogen Sulfide in Tumor-Bearing Mice

Ling Yan et al.

Summary: Endogenous hydrogen sulfide (H2S) is closely associated with various cancers and can be regarded as a biomarker of cancer. A new near-infrared fluorescent probe with high sensitivity and rapid detection ability has been constructed for sensing and distinguishing hydrogen sulfide (H2S) in tumor cells, which shows potential for cancer diagnosis.

ANALYTICAL CHEMISTRY (2022)

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Article Biochemistry & Molecular Biology

A bifunctional fluorescent probe based on PET & ICT for simultaneously recognizing Cys and H2S in living cells

Huawei Niu et al.

Summary: Most existing probes can only identify Cys or H2S and are interfered by other molecules. In this study, a bifunctional fluorescent probe NJB was constructed to respond to Cys and H2S through PET & ICT processes. NJB showed excellent selectivity and low detection limits for Cys and HS-. It has been successfully applied in cellular detection and holds promise for studying the physiological and pathological functions of Cys and H2S.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY (2022)

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Article Chemistry, Analytical

Rapid and sensitive detection of H2S by a 4-phenylselenium coumarin as a dual-active-site fluorescent probe

Xiang-Gen Chen et al.

Summary: A novel fluorescent probe PhSeCou was developed for rapid, selective, and sensitive detection of H2S, displaying high selectivity and an ultra-low detection limit. Through fluorescence cell-imaging, both exo- and endogenous H2S in living cells were successfully detected using PhSeCou.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

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Article Chemistry, Analytical

Simultaneous Sensing of H2S and ATP with a Two-Photon Fluorescent Probe in Alzheimer's Disease: toward Understanding Why H2S Regulates Glutamate-Induced ATP Dysregulation

Panpan Sun et al.

Summary: This study developed a two-photon fluorescent probe named AD-3 that can simultaneously image H2S and ATP. The probe showed high selectivity and good detection linearity for both H2S and ATP, and it was successfully used for imaging and quantification of H2S and ATP in neuronal cells. Further investigations revealed the mechanism of H2S regulation on ATP synthesis and the probe was used for high-throughput screening of potential anti-AD drugs. AD-3 probe was also capable of imaging H2S and ATP in AD mouse brain.

ANALYTICAL CHEMISTRY (2022)

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Article Engineering, Environmental

Dual-site fluorescent sensor for tracking lysosomal ATP and H2S during liver injury

Xiaopeng Yang et al.

Summary: The researchers have designed a dual-site fluorescent sensor, RDNA-1, which can track ATP and H2S in lysosomes and has been successfully used to detect changes in liver injury. The study also found that H2S has the potential to repair damaged liver cells. In addition, RDNA-1 enables in vivo imaging of zebrafish, which helps to study the physiological mechanisms of liver injury.

CHEMICAL ENGINEERING JOURNAL (2022)

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Article Spectroscopy

A highly selective colorimetric and fluorescent probe Eu(tdl)2abp for H2S sensing: Application in live cell imaging and natural water

Xiaoxia Chen et al.

Summary: In this study, a new europium complex fluorescent probe Eu(tdl)2abp was successfully synthesized for efficient and specific recognition of hydrogen sulfide (H2S). The probe exhibited on-off fluorescence signals for H2S and its color changes could be observed with naked eyes. Eu(tdl)2abp showed a short response time, high selectivity, good anti-interference, and a large Stokes shift. The probe demonstrated a linear relationship between relative fluorescence intensity and H2S concentration with a low detection limit. The mechanism of H2S detection using Eu(tdl)2abp was characterized and the probe was successfully applied in the detection of H2S in natural water and living cells.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2022)

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Article Chemistry, Analytical

A super sensitive fluorescent probe for imaging endogenous hydrogen sulfide in living cells

Junli Peng et al.

Summary: This study describes the design and biological applications of a novel fluorescence probe, SS-N-3, for the detection of hydrogen sulfide in vivo. The probe exhibits high selectivity and sensitivity to hydrogen sulfide, with strong anti-interference capacity. Additionally, the probe shows low cytotoxicity, improved photostability, and a large Stokes shift, making it an effective indicator of hydrogen sulfide levels in living cells.

TALANTA (2022)

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Article Environmental Sciences

Effects of Vallisneria natans on H2S and S2- releases in black-odorous waterbody under additional nitrate: Comprehensive performance and microbial community structure

Yao Lu et al.

Summary: Releases of hydrogen sulphide (H2S) and sulphur ions (S2-) through sulphate reduction in black-odorous waterbody is a great environmental health concern. Aquatic planting for blackening and odour controls has received great attention in research and practice. This controlled laboratory study explored the changes of H2S and S2- releases in simulated black-odorous waterbody planted with Vallisneria natans and artificial plants (control). V. natans growth was stimulated by additional nitrate (6.6 mg/L NO3- -N), resulting in an increase of dissolved oxygen (DO) and pH in overlying water and an 11.0% decrease in removal efficiency of chemical oxygen demand (COD). At relatively low nitrate level (i.e., 2.0 mg/L NO3- -N in the absence of additional nitrate), V. natans after the 48th day inhibited H2S and S2- releases by 81.5% and 66.8%, respectively, and their inhibition efficiencies were improved to 95.7% and 98.8% by the presence of additional nitrate. Additional nitrate reduced the relative abundance of sulphatereducing bacteria (SRB) in the sediments while increased the relative abundance of sulphur-oxidizing bacteria (SOB) and nitrate-reducing sulphur-oxidizing bacteria (NR-SOB) in the leaf biofilms of V. natans and artificial plants. Genus compositions in leaf biofilms showed host specificity. Pearson correlation analysis showed that DO, pH, and nitrate concentration had a positive correlation with the relative abundance of SOB (Aeromonas) and NRSOB (Hydrogenophaga), while were negatively correlated with the relative abundance of SRB (MSBL7). These results indicated that V. natans under additional nitrate altered microbial community to be unfavourable for H2S and S2- releases. This study clarified the inhibition of H2S and S2- releases by aquatic planting under additional nitrate and provided theoretical basis for improving black-odorous waterbody restoration technology.

JOURNAL OF ENVIRONMENTAL MANAGEMENT (2022)

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Article Engineering, Environmental

An indirect detection strategy-assisted self-cleaning electrochemical platform for in-situ and pretreatment-free detection of endogenous H2S from sulfate-reducing bacteria (SRB)

Zhenhao Wang et al.

Summary: A synergistic sensing platform based on self-cleaning electrode interface and indirect detection strategy was developed to directly detect H2S generated by SRB in complex culture medium, overcoming issues such as nonspecific adsorption and electrode passivation.

JOURNAL OF HAZARDOUS MATERIALS (2022)

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Article Optics

Red luminous ternary europium complexes: Optoelectronic and photophysical analysis

Anjli Hooda et al.

JOURNAL OF LUMINESCENCE (2022)

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Article Chemistry, Physical

An H2S-Regulated Artificial Nanochannel Fabricated by a Supramolecular Coordination Strategy

Huan Qin et al.

Summary: In this study, an artificial nanochannel with a conductance value of 2.01 nS was successfully fabricated using a supramolecular coordination strategy. Utilizing the unique H2S-mediated covalent reaction, the nanochannel biosensor was able to switch from ON to OFF states upon the addition of H2S. Furthermore, the nanochannel exhibited high rectification ratio and gating ratio, directing ion transport. Theoretical simulations were conducted to provide insights into the possible mechanism of the functionalized nanochannel.

JOURNAL OF PHYSICAL CHEMISTRY LETTERS (2022)

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Article Chemistry, Multidisciplinary

Near-Infrared Fluorescent Probe for H2S Detection: Will pH Affect the Intracellular Sensing?

Xiaowen Guan et al.

Summary: Near-infrared fluorescent probes have potential applications in detecting H2S, but the pH-dependent emission and H2S conversions affect accurate detection. This study uses experiments and theoretical calculations to study the effect of pH on intracellular H2S sensing using an NIR probe. The results confirm the pH-dependent emission of the probe and propose a mechanism involving nucleophilic substitution and hydrolysis with increasing pH.

ACS SENSORS (2022)

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Editorial Material Biochemistry & Molecular Biology

Novel Regulatory Roles of Hydrogen Sulfide in Health and Disease

Csaba Szabo

BIOMOLECULES (2022)

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Article Clinical Neurology

Plasma hydrogen sulfide: A biomarker of Alzheimer's disease and related dementias

Elizabeth Disbrow et al.

Summary: Hydrogen sulfide (H2S) plays an important role in cerebrovascular disease and cognitive dysfunction. Studies have found elevated levels of H2S in ADRD, which are correlated with microvascular disease indices.

ALZHEIMERS & DEMENTIA (2021)

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Article Chemistry, Applied

Si-coumarin-based fluorescent probes for ultrafast monitoring H2S in vivo

Yan Sun et al.

Summary: Silicon substituted coumarins SiC-Azs show high sensitivity and selectivity for monitoring cellular hydrogen sulfide, with rapid equilibrium achieved. The probe SiC-Az2 is highly sensitive for detecting endogenous and exogenous hydrogen sulfide in Hela cells and zebrafish.

DYES AND PIGMENTS (2021)

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Review Biochemistry & Molecular Biology

Harnessing the Benefits of Endogenous Hydrogen Sulfide to Reduce Cardiovascular Disease

Kevin M. Casin et al.

Summary: Cardiovascular disease is the leading cause of death in the U.S. Research has shown the beneficial impact of endogenous hydrogen sulfide production on heart health; modulating H2S enzyme sources is a promising research area.

ANTIOXIDANTS (2021)

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Article Materials Science, Multidisciplinary

Luminescent heteroleptic Eu(iii) probes for the selective detection of diethyl chlorophosphate as a G-series nerve agent mimic in the vapor phase using solid-state films

Zafar Abbas et al.

Summary: This study developed two time-resolved luminescent Ln(III) probes for selective detection of nerve agent simulants. By incorporating specific chemical functional groups, sensitive detection and quenching of nerve agents were achieved. Utilizing luminescence spectroscopy, a low-cost detection method targeting nerve agents was developed.

JOURNAL OF MATERIALS CHEMISTRY C (2021)

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Review Biochemistry & Molecular Biology