Journal
JOURNAL OF BIOCHEMISTRY
Volume -, Issue -, Pages -Publisher
OXFORD UNIV PRESS
DOI: 10.1093/jb/mvad084
Keywords
actin cortex; amoeboid migration; bleb; cytoplasmic zoning
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Blebs are membrane structures formed by detachment of the plasma membrane from the underlying actin cytoskeleton. Recent studies have revealed the importance of cytoplasmic zoning in bleb expansion.
Blebs are membrane structures formed by the detachment of the plasma membrane from the underlying actin cytoskeleton. It is now clear that a wide variety of cells, including cancer cells, actively form blebs for cell migration and cell survival. The expansion of blebs has been regarded as the passive ballooning of the plasma membrane by an abrupt increase in intracellular pressure. However, recent studies revealed the importance of 'cytoplasmic zoning', i.e. local changes in the hydrodynamic properties and the ionic and protein content of the cytoplasm. In this review, we summarize the current understanding of the molecular mechanisms behind cytoplasmic zoning and its role in bleb expansion. Graphical Abstract
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