Journal
JOURNAL OF INFECTIOUS DISEASES
Volume -, Issue -, Pages -Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiad488
Keywords
HIV; menopause; cardiovascular disease; atherosclerosis
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This study suggests that menopause may accelerate subclinical atherosclerosis as measured by CIMT in HIV patients.
The menopausal transition is a pivotal time of cardiovascular risk, but knowledge is limited in HIV. We studied longitudinal carotid artery intima-media thickness (CIMT) in the Women's Interagency HIV Study (2004-2019; 979 women/3247 person-visits; 72% with HIV). Among women with HIV only, those who transitioned had greater age-related CIMT progression compared to those remaining premenopausal (difference in slope = 1.64 mu m/year, P = .002); and CIMT increased over time in the pretransition (3.47 mu m/year, P = .002) and during the menopausal transition (9.41 mu m/year, P < .0001), but not posttransition (2.9 mu m/year, P = .19). In women with HIV, menopause may accelerate subclinical atherosclerosis as measured by CIMT.
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