Journal
FRONTIERS IN PHYSIOLOGY
Volume 14, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphys.2023.1281555
Keywords
protein modification; autophagy; Bombyx mori; Drosophila melanogaster; insects
Categories
Ask authors/readers for more resources
This article discusses the importance of post-translational modifications in the regulation of autophagy in insects, including Bombyx mori and Drosophila melanogaster. A deeper understanding of the biological significance of post-translational modifications in autophagy machinery provides new opportunities for autophagy intervention strategies and reveals their potential roles in development, cell differentiation, and the process of learning and memory in both insects and mammals.
Post-translational modifications refer to the chemical alterations of proteins following their biosynthesis, leading to changes in protein properties. These modifications, which encompass acetylation, phosphorylation, methylation, SUMOylation, ubiquitination, and others, are pivotal in a myriad of cellular functions. Macroautophagy, also known as autophagy, is a major degradation of intracellular components to cope with stress conditions and strictly regulated by nutrient depletion, insulin signaling, and energy production in mammals. Intriguingly, in insects, 20-hydroxyecdysone signaling predominantly stimulates the expression of most autophagy-related genes while concurrently inhibiting mTOR activity, thereby initiating autophagy. In this review, we will outline post-translational modification-regulated autophagy in insects, including Bombyx mori and Drosophila melanogaster, in brief. A more profound understanding of the biological significance of post-translational modifications in autophagy machinery not only unveils novel opportunities for autophagy intervention strategies but also illuminates their potential roles in development, cell differentiation, and the process of learning and memory processes in both insects and mammals.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available