Journal
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
Volume 17, Issue 5-6, Pages 377-384Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/21678421.2016.1154575
Keywords
Amyotrophic lateral sclerosis; Physical Activity; Risk factor; Epidemiology; Gene-environment interaction
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Funding
- Medical Research Council/Motor Neurone Disease Association Lady Edith Wolfson Fellowship
- Medical Research Council [MC_U106179473, MC_UU_12015/1, MC_PC_13048, MR/K000039/1, MC_UU_12015/3, MC_U106179471, G0802332] Funding Source: researchfish
- Motor Neurone Disease Association [Shaw/Apr15/933-794] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0512-10082, NF-SI-0512-10135] Funding Source: researchfish
- MRC [MC_UU_12015/3, MC_UU_12015/1, G0802332, MC_U106179473, MR/K000039/1] Funding Source: UKRI
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Objectives: To conduct a geographically defined, UK-based case-control study, to examine any association between physical activity (PA) and amyotrophic lateral sclerosis (ALS). Methods: A novel historical PA questionnaire was designed, validated, and subsequently administered in individual face-to-face interviews of 175 newly diagnosed sporadic ALS cases and 317 age- and sex-matched community controls. Historical PA energy expenditure and time spent in vigorous-intensity PA were derived from questionnaire data and compared between cases and controls. Results: Participation in an extra 10kJ/kg/day of PA (equivalent to approximately 45minutes brisk walking) was consistently associated with an increased risk of ALS, with the strongest association observed for adulthood exercise-related PA (OR 1.47, 95% CI 1.10-1.97). An extra 10mins/day of vigorous PA was also associated with the odds of ALS (OR 1.03, 95% CI 101-105). Results were slightly attenuated following adjustment for smoking and educational attainment. Conclusions: To our knowledge this is the first study to demonstrate a positive association between ALS and PA participation using a specifically designed and validated historical PA questionnaire. Despite the well-established health benefits of PA, a high activity lifestyle may also be associated with elevated risk of ALS. Large-scale prospective studies in the future may help to confirm this association.
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