Journal
STEM CELL RESEARCH
Volume 73, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.scr.2023.103224
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In this study, a human induced pluripotent stem cell line was generated from urine cells of a chronic kidney disease patient using non-integrating administration of RNAs. The iPSCs exhibited typical characteristics and pluripotency marker expression, making them a valuable source for disease modeling and personalized therapeutic approaches.
Chronic kidney disease is a major public health burden associated with a drastically reduced quality of living and life span that lacks suitable, individualized therapeutic strategies. Here we present a human induced pluripotent stem cell line (iPSC, UMGACBi001-A) reprogrammed from urine cells of an acute septic dialysis patient suffering from chronic kidney disease using non-integrating administration of RNAs. The generated iPSCs were positively characterized for typical morphology, pluripotency marker expression, directed differentiation potential, non-contamination, chromosomal consistency and donor identity. This iPSC-line can be a useful source for in vitro disease modelling and individualized therapeutic approaches.
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