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CURRENT OPINION IN STRUCTURAL BIOLOGY (2018)
Folding and binding pathways of BH3-only proteins are encoded within their intrinsically disordered sequence, not templated by partner proteins
Michael D. Crabtree et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2018)
Tadpole-like Conformations of Huntingtin Exon 1 Are Characterized by Conformational Heterogeneity that Persists regardless of Polyglutamine Length
Estella A. Newcombe et al.
JOURNAL OF MOLECULAR BIOLOGY (2018)
Sequence-to-Conformation Relationships of Disordered Regions Tethered to Folded Domains of Proteins
Anuradha Mittal et al.
JOURNAL OF MOLECULAR BIOLOGY (2018)
Intrinsically Disordered Proteins Link Alternative Splicing and Post-translational Modifications to Complex Cell Signaling and Regulation
Jianhong Zhou et al.
JOURNAL OF MOLECULAR BIOLOGY (2018)
Ubiquitin Modulates Liquid-Liquid Phase Separation of UBQLN2 via Disruption of Multivalent Interactions
Thuy P. Dao et al.
MOLECULAR CELL (2018)
Regulation of apoptosis by an intrinsically disordered region of Bcl-xL
Ariele Viacava Follis et al.
NATURE CHEMICAL BIOLOGY (2018)
Developing a molecular dynamics force field for both folded and disordered protein states
Paul Robustelli et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Short linear motif core and flanking regions modulate retinoblastoma protein binding affinity and specificity
Nicolas Palopoli et al.
PROTEIN ENGINEERING DESIGN & SELECTION (2018)
Disordered linkers in multidomain allosteric proteins: Entropic effect to favor the open state or enhanced local concentration to favor the closed state?
Maodong Li et al.
PROTEIN SCIENCE (2018)
Physical principles of intracellular organization via active and passive phase transitions
Joel Berry et al.
REPORTS ON PROGRESS IN PHYSICS (2018)
Imaging dynamic and selective low-complexity domain interactions that control gene transcription
Shasha Chong et al.
SCIENCE (2018)
A liquid phase of synapsin and lipid vesicles
Dragomir Milovanovic et al.
SCIENCE (2018)
Mediator and RNA polymerase II clusters associate in transcription-dependent condensates
Won-Ki Cho et al.
SCIENCE (2018)
Phase separation of a yeast prion protein promotes cellular fitness
Titus M. Franzmann et al.
SCIENCE (2018)
Organization and Function of Non-dynamic Biomolecular Condensates
Jeffrey B. Woodruff et al.
TRENDS IN BIOCHEMICAL SCIENCES (2018)
Protein Phase Separation: A New Phase in Cell Biology
Steven Boeynaems et al.
TRENDS IN CELL BIOLOGY (2018)
Gcn4-Mediator Specificity Is Mediated by a Large and Dynamic Fuzzy Protein-Protein Complex
Lisa M. Tuttle et al.
CELL REPORTS (2018)
Sequence determinants of protein phase behavior from a coarse-grained model
Gregory L. Dignon et al.
PLOS COMPUTATIONAL BIOLOGY (2018)
Multivalency regulates activity in an intrinsically disordered transcription factor
Sarah Clark et al.
ELIFE (2018)
A High-Throughput Mutational Scan of an Intrinsically Disordered Acidic Transcriptional Activation Domain
Max V. Staller et al.
CELL SYSTEMS (2018)
Mutations in Disordered Regions Can Cause Disease by Creating Dileucine Motifs
Katrina Meyer et al.
CELL (2018)
Extreme disorder in an ultrahigh-affinity protein complex
Alessandro Borgia et al.
NATURE (2018)
Relation between single-molecule properties and phase behavior of intrinsically disordered proteins
Gregory L. Dignon et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Identifying weak interdomain interactions that stabilize the supertertiary structure of the N-terminal tandem PDZ domains of PSD-95
Inna S. Yanez Orozco et al.
NATURE COMMUNICATIONS (2018)
An ultraweak interaction in the intrinsically disordered replication machinery is essential for measles virus function
Sigrid Milles et al.
SCIENCE ADVANCES (2018)
Co-Evolution of Intrinsically Disordered Proteins with Folded Partners Witnessed by Evolutionary Couplings
Rita Pancsa et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
The entropic force generated by intrinsically disordered segments tunes protein function
Nicholas D. Keul et al.
NATURE (2018)
Long-range regulation of p53 DNA binding by its intrinsically disordered N-terminal transactivation domain
Alexander S. Krois et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Engineering allosteric regulation in protein kinases
David Pincus et al.
SCIENCE SIGNALING (2018)
Transition path times of coupled folding and binding reveal the formation of an encounter complex
Flurin Sturzenegger et al.
NATURE COMMUNICATIONS (2018)
Synergy between intrinsically disordered domains and structured proteins amplifies membrane curvature sensing
Wade F. Zeno et al.
NATURE COMMUNICATIONS (2018)
Structure and dynamics conspire in the evolution of affinity between intrinsically disordered proteins
Per Jemth et al.
SCIENCE ADVANCES (2018)
Structures and Short Linear Motif of Disordered Transcription Factor Regions Provide Clues to the Interactome of the Cellular Hub Protein Radical-induced Cell Death1
Charlotte O'Shea et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2017)
CHARMM36m: an improved force field for folded and intrinsically disordered proteins
Jing Huang et al.
NATURE METHODS (2017)
The Transactivation Domains of the p53 Protein
Nitin Raj et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2017)
Regulation of Nucleosome Stacking and Chromatin Compaction by the Histone H4 N-Terminal Tail-H2A Acidic Patch Interaction
Qinming Chen et al.
JOURNAL OF MOLECULAR BIOLOGY (2017)
Monomeric Huntingtin Exon 1 Has Similar Overall Structural Features for Wild-Type and Pathological Polyglutamine Lengths
John B. Warner et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)
Allosteric Modulation of Grb2 Recruitment to the Intrinsically Disordered Scaffold Protein, LAT, by Remote Site Phosphorylation
William Y. C. Huang et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)
Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics
Steven Boeynaems et al.
MOLECULAR CELL (2017)
Tardigrades Use Intrinsically Disordered Proteins to Survive Desiccation
Thomas C. Boothby et al.
MOLECULAR CELL (2017)
Hypersensitive termination of the hypoxic response by a disordered protein switch
Rebecca B. Berlow et al.
NATURE (2017)
Biomolecular condensates: organizers of cellular biochemistry
Salman F. Banani et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)
Selection maintains signaling function of a highly diverged intrinsically disordered region
Taraneh Zarin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Phosphorylation-induced conformational dynamics in an intrinsically disordered protein and potential role in phenotypic heterogeneity
Prakash Kulkarni et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Affinity of IDPs to their targets is modulated by ion-specific changes in kinetics and residual structure
Basile I. M. Wicky et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Decoupling of size and shape fluctuations in heteropolymeric sequences reconciles discrepancies in SAXS vs. FRET measurements
Gustavo Fuertes et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Structural and hydrodynamic properties of an intrinsically disordered region of a germ cell-specific protein on phase separation
Jacob P. Brady et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Control of transcriptional activity by design of charge patterning in the intrinsically disordered RAM region of the Notch receptor
Kathryn P. Sherry et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Innovative scattering analysis shows that hydrophobic disordered proteins are expanded in water
Joshua A. Riback et al.
SCIENCE (2017)
Liquid phase condensation in cell physiology and disease
Yongdae Shin et al.
SCIENCE (2017)
Degrons in cancer
Balint Meszaros et al.
SCIENCE SIGNALING (2017)
Structural heterogeneity in the intrinsically disordered RNA polymerase II C-terminal domain
Bede Portz et al.
NATURE COMMUNICATIONS (2017)
Phosphorylation induces sequence-specific conformational switches in the RNA polymerase II C-terminal domain
Eric B. Gibbs et al.
NATURE COMMUNICATIONS (2017)
Degrons in cancer
Balint Meszaros et al.
SCIENCE SIGNALING (2017)
Intrinsically Disordered Proteins and Desiccation Tolerance: Elucidating Functional and Mechanistic Underpinnings of Anhydrobiosis
Thomas C. Boothby et al.
BIOESSAYS (2017)
Structural Biology outside the box - inside the cell
Juergen M. Plitzko et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2017)
A phosphorylation-motif for tuneable helix stabilisation in intrinsically disordered proteins - Lessons from the sodium proton exchanger 1 (NHE1)
Ruth Hendus-Altenburger et al.
CELLULAR SIGNALLING (2017)
Application of NMR to studies of intrinsically disordered proteins
Eric B. Gibbs et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2017)
Behaviour of intrinsically disordered proteins in protein-protein complexes with an emphasis on fuzziness
Johan G. Olsen et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2017)
Optimal Affinity Enhancement by a Conserved Flexible Linker Controls p53 Mimicry in MdmX
Wade Borcherds et al.
BIOPHYSICAL JOURNAL (2017)
Phase Separation and Single-Chain Compactness of Charged Disordered Proteins Are Strongly Correlated
Yi-Hsuan Lin et al.
BIOPHYSICAL JOURNAL (2017)
Conserved Helix-Flanking Prolines Modulate Intrinsically Disordered Protein:Target Affinity by Altering the Lifetime of the Bound Complex
Michael D. Crabtree et al.
BIOCHEMISTRY (2017)
Stress-Triggered Phase Separation Is an Adaptive, Evolutionarily Tuned Response
Joshua A. Riback et al.
CELL (2017)
Principles of protein structural ensemble determination
Massimiliano Bonomi et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2017)
CIDER: Resources to Analyze Sequence-Ensemble Relationships of Intrinsically Disordered Proteins
Alex S. Holehouse et al.
BIOPHYSICAL JOURNAL (2017)
A Rigorous and Efficient Method To Reweight Very Large Conformational Ensembles Using Average Experimental Data and To Determine Their Relative Information Content
Hoi Tik Alvin Leung et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2016)
Single-Molecule FRET Spectroscopy and the Polymer Physics of Unfolded and Intrinsically Disordered Proteins
Benjamin Schuler et al.
ANNUAL REVIEW OF BIOPHYSICS, VOL 45 (2016)
The human Na+/H+ exchanger 1 is a membrane scaffold protein for extracellular signal-regulated kinase 2
Ruth Hendus-Altenburger et al.
BMC BIOLOGY (2016)
Structured States of Disordered Proteins from Genomic Sequences
Agnes Toth-Petroczy et al.
CELL (2016)
Compositional Control of Phase-Separated Cellular Bodies
Salman F. Banani et al.
CELL (2016)
Coexisting Liquid Phases Underlie Nucleolar Subcompartments
Marina Feric et al.
CELL (2016)
Insights into Coupled Folding and Binding Mechanisms from Kinetic Studies
Sarah L. Shammas et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Experimental Inferential Structure Determination of Ensembles for Intrinsically Disordered Proteins
David H. Brookes et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)
Probing the Action of Chemical Denaturant on an Intrinsically Disordered Protein by Simulation and Experiment
Wenwei Zheng et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)
Consistent View of Polypeptide Chain Expansion in Chemical Denaturants from Multiple Experimental Methods
Alessandro Borgia et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)
Sequence Determinants of the Conformational Properties of an Intrinsically Disordered Protein Prior to and upon Multisite Phosphorylation
Erik W. Martin et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)
Sequence Determinants of Intracellular Phase Separation by Complex Coacervation of a Disordered Protein
Chi W. Pak et al.
MOLECULAR CELL (2016)
Structural disorder of monomeric α-synuclein persists in mammalian cells
Francois-Xavier Theillet et al.
NATURE (2016)
Ki-67 acts as a biological surfactant to disperse mitotic chromosomes
Sara Cuylen et al.
NATURE (2016)
Membraneless organelles can melt nucleic acid duplexes and act as biomolecular filters
Timothy J. Nott et al.
NATURE CHEMISTRY (2016)
Cryptic sequence features within the disordered protein p27Kip1 regulate cell cycle signaling
Rahul K. Das et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Molecular Recognition by Templated Folding of an Intrinsically Disordered Protein
Angelo Toto et al.
SCIENTIFIC REPORTS (2016)
Metainference: A Bayesian inference method for heterogeneous systems
Massimiliano Bonomi et al.
SCIENCE ADVANCES (2016)
Characterization of the p300 Taz2-p53 TAD2 Complex and Comparison with the p300 Taz2-p53 TAD1 Complex
Lisa M. Miller Jenkins et al.
BIOCHEMISTRY (2015)
Compartmentalization of a Bistable Switch Enables Memory to Cross a Feedback-Driven Transition
Andreas Doncic et al.
CELL (2015)
Plasticity of an Ultrafast Interaction between Nucleoporins and Nuclear Transport Receptors
Sigrid Milles et al.
CELL (2015)
A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation
Avinash Patel et al.
CELL (2015)
Short linear motifs - ex nihilo evolution of protein regulation
Norman E. Davey et al.
CELL COMMUNICATION AND SIGNALING (2015)
Theoretical perspectives on nonnative interactions and intrinsic disorder in protein folding and binding
Tao Chen et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2015)
Relating sequence encoded information to form and function of intrinsically disordered proteins
Rahul K. Das et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2015)
Fuzzy complexes: Specific binding without complete folding
Rashmi Sharma et al.
FEBS LETTERS (2015)
A practical guide to small angle X-ray scattering (SAXS) of flexible and intrinsically disordered proteins
Alexey G. Kikhney et al.
FEBS LETTERS (2015)
A theoretical method to compute sequence dependent configurational properties in charged polymers and proteins
Lucas Sawle et al.
JOURNAL OF CHEMICAL PHYSICS (2015)
Effects of Linker Length and Transient Secondary Structure Elements in the Intrinsically Disordered Notch RAM Region on Notch Signaling
Kathryn P. Sherry et al.
JOURNAL OF MOLECULAR BIOLOGY (2015)
Sequence- and Temperature-Dependent Properties of Unfolded and Disordered Proteins from Atomistic Simulations
Guel H. Zerze et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2015)
Water Dispersion Interactions Strongly Influence Simulated Structural Properties of Disordered Protein States
Stefano Piana et al.
JOURNAL OF PHYSICAL CHEMISTRY B (2015)
Quantitative Assessments of the Distinct Contributions of Polypeptide Backbone Amides versus Side Chain Groups to Chain Expansion via Chemical Denaturation
Alex S. Holehouse et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)
A Period2 Phosphoswitch Regulates and Temperature Compensates Circadian Period
Min Zhou et al.
MOLECULAR CELL (2015)
Variable Glutamine-Rich Repeats Modulate Transcription Factor Activity
Rita Gemayel et al.
MOLECULAR CELL (2015)
Residue-by-Residue View of In Vitro FUS Granules that Bind the C-Terminal Domain of RNA Polymerase II
Kathleen A. Burke et al.
MOLECULAR CELL (2015)
Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles
Timothy J. Nott et al.
MOLECULAR CELL (2015)
Sequence heuristics to encode phase behaviour in intrinsically disordered protein polymers
Felipe Garcia Quiroz et al.
NATURE MATERIALS (2015)
Single-molecule spectroscopy of protein conformational dynamics in live eukaryotic cells
Iwo Koenig et al.
NATURE METHODS (2015)
Polymer physics of intracellular phase transitions
Clifford P. Brangwynne et al.
NATURE PHYSICS (2015)
Intrinsically disordered proteins in cellular signalling and regulation
Peter E. Wright et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2015)
Induced folding in RNA recognition by Arabidopsis thaliana DCL1
Irina P. Suarez et al.
NUCLEIC ACIDS RESEARCH (2015)
Conformational propensities of intrinsically disordered proteins influence the mechanism of binding and folding
Munehito Arai et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics
Shana Elbaum-Garfinkle et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose)
Matthias Altmeyer et al.
NATURE COMMUNICATIONS (2015)
Intrinsically disordered proteins drive membrane curvature
David J. Busch et al.
NATURE COMMUNICATIONS (2015)
Advanced ensemble modelling of flexible macromolecules using X-ray solution scattering
Giancarlo Tria et al.
IUCRJ (2015)
Accuracy of Current All-Atom Force-Fields in Modeling Protein Disordered States
Ferruccio Palazzesi et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2015)
Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch
Alaji Bah et al.
NATURE (2015)
Globular and disordered-the non-identical twins in protein-protein interactions
Kaare Teilum et al.
FRONTIERS IN MOLECULAR BIOSCIENCES (2015)
Rethinking gene regulatory networks in light of alternative splicing, intrinsically disordered protein domains, and post-translational modifications
Karl J. Niklas et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2015)
Distinguishing induced fit from conformational selection
Stefano Gianni et al.
BIOPHYSICAL CHEMISTRY (2014)
Only Kinetics Can Prove Conformational Selection
Jakob Dogan et al.
BIOPHYSICAL JOURNAL (2014)
Single-Molecule Studies of Intrinsically Disordered Proteins
Marco Brucale et al.
CHEMICAL REVIEWS (2014)
Physicochemical Properties of Cells and Their Effects on Intrinsically Disordered Proteins (IDPs)
Francois-Xavier Theillet et al.
CHEMICAL REVIEWS (2014)
Classification of Intrinsically Disordered Regions and Proteins
Robin van der Lee et al.
CHEMICAL REVIEWS (2014)
Balanced Protein-Water Interactions Improve Properties of Disordered Proteins and Non-Specific Protein Association
Robert B. Best et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2014)
Coupled Folding and Binding of the Disordered Protein PUMA Does Not Require Particular Residual Structure
Joseph M. Rogers et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)
A Million Peptide Motifs for the Molecular Biologist
Peter Tompa et al.
MOLECULAR CELL (2014)
The ensemble nature of allostery
Hesam N. Motlagh et al.
NATURE (2014)
Disorder and residual helicity alter p53-Mdm2 binding affinity and signaling in cells
Wade Borcherds et al.
NATURE CHEMICAL BIOLOGY (2014)
Interplay between partner and ligand facilitates the folding and binding of an intrinsically disordered protein
Joseph M. Rogers et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Temperature-dependent solvation modulates the dimensions of disordered proteins
Rene Wuttke et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Single-molecule spectroscopy reveals polymer effects of disordered proteins in crowded environments
Andrea Soranno et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Describing sequence-ensemble relationships for intrinsically disordered proteins
Albert H. Mao et al.
BIOCHEMICAL JOURNAL (2013)
Hydrogen-exchange mass spectrometry for the study of intrinsic disorder in proteins
Deepa Balasubramaniam et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2013)
Alternative splicing of intrinsically disordered regions and rewiring of protein interactions
Marija Buljan et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2013)
Folding and Binding of an Intrinsically Disordered Protein: Fast, but Not 'Diffusion-Limited'
Joseph M. Rogers et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)
Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS
Hong Joo Kim et al.
NATURE (2013)
Multisite phosphorylation networks as signal processors for Cdk1
Mardo Koivomaegi et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2013)
Conformations of intrinsically disordered proteins are influenced by linear sequence distributions of oppositely charged residues
Rahul K. Das et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
The SH3 domain of HS1 protein recognizes lysine-rich polyproline motifs
Giuliano Siligardi et al.
AMINO ACIDS (2012)
A folding-after-binding mechanism describes the recognition between the transactivation domain of c-Myb and the KIX domain of the CREB-binding protein
Stefano Gianni et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)
Regulation of protein phosphatase 1 by intrinsically disordered proteins
Meng S. Choy et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2012)
Flexible-meccano: a tool for the generation of explicit ensemble descriptions of intrinsically disordered proteins and their associated experimental observables
Valery Ozenne et al.
BIOINFORMATICS (2012)
Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels
Masato Kato et al.
CELL (2012)
Cell-free Formation of RNA Granules: Bound RNAs Identify Features and Components of Cellular Assemblies
Tina W. Han et al.
CELL (2012)
Fast Association and Slow Transitions in the Interaction between Two Intrinsically Disordered Protein Domains
Jakob Dogan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Orderly order in protein intrinsic disorder distribution: disorder in 3500 proteomes from viruses and the three domains of life
Bin Xue et al.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2012)
N-Terminal Segments Modulate the α-Helical Propensities of the Intrinsically Disordered Basic Regions of bZIP Proteins
Rahul K. Das et al.
JOURNAL OF MOLECULAR BIOLOGY (2012)
Disease mutations in disordered regions-exception to the rule?
Vladimir Vacic et al.
MOLECULAR BIOSYSTEMS (2012)
Attributes of short linear motifs
Norman E. Davey et al.
MOLECULAR BIOSYSTEMS (2012)
Tissue-Specific Splicing of Disordered Segments that Embed Binding Motifs Rewires Protein Interaction Networks
Marija Buljan et al.
MOLECULAR CELL (2012)
Phase transitions in the assembly of multivalent signalling proteins
Pilong Li et al.
NATURE (2012)
A core subunit of Polycomb repressive complex 1 is broadly conserved in function but not primary sequence
Leslie Y. Beh et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Versatility from Protein Disorder
M. Madan Babu et al.
SCIENCE (2012)
HMGB1-Facilitated p53 DNA Binding Occurs via HMG-Box/p53 Transactivation Domain Interaction, Regulated by the Acidic Tail
John P. Rowell et al.
STRUCTURE (2012)
Transport of Fibroblast Growth Factor 2 in the Pericellular Matrix Is Controlled by the Spatial Distribution of Its Binding Sites in Heparan Sulfate
Laurence Duchesne et al.
PLOS BIOLOGY (2012)
Disease-Associated Mutations Disrupt Functionally Important Regions of Intrinsic Protein Disorder
Vladimir Vacic et al.
PLOS COMPUTATIONAL BIOLOGY (2012)
Evolution and disorder
Celeste J. Brown et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2011)
The Acidic Transcription Activator Gcn4 Binds the Mediator Subunit Gal11/Med15 Using a Simple Protein Interface Forming a Fuzzy Complex
Peter S. Brzovic et al.
MOLECULAR CELL (2011)
Structure of the p53 Transactivation Domain in Complex with the Nuclear Receptor Coactivator Binding Domain of CREB Binding Protein
Chul Won Lee et al.
BIOCHEMISTRY (2010)
Sequence Determinants of Compaction in Intrinsically Disordered Proteins
Joseph A. Marsh et al.
BIOPHYSICAL JOURNAL (2010)
Proline-Rich Salivary Proteins Have Extended Conformations
Helene Boze et al.
BIOPHYSICAL JOURNAL (2010)
Drosophila heparan sulfate 6-O endosulfatase regulates Wingless morphogen gradient formation
Adam Kleinschmit et al.
DEVELOPMENTAL BIOLOGY (2010)
Comparing Models of Evolution for Ordered and Disordered Proteins
Celeste J. Brown et al.
MOLECULAR BIOLOGY AND EVOLUTION (2010)
Caulobacter PopZ forms a polar subdomain dictating sequential changes in pole composition and function
Grant R. Bowman et al.
MOLECULAR MICROBIOLOGY (2010)
Direct detection of CH/π interactions in proteins
Michael J. Plevin et al.
NATURE CHEMISTRY (2010)
Net charge per residue modulates conformational ensembles of intrinsically disordered proteins
Albert H. Mao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Charge interactions can dominate the dimensions of intrinsically disordered proteins
Sonja Mueller-Spaeth et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Temperature-dependent structural changes in intrinsically disordered proteins: Formation of α-helices or loss of polyproline II?
Magnus Kjaergaard et al.
PROTEIN SCIENCE (2010)
Masking residues using context-specific evolutionary conservation significantly improves short linear motif discovery
Norman E. Davey et al.
BIOINFORMATICS (2009)
Linking folding and binding
Peter E. Wright et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2009)
ABSINTH: A New Continuum Solvation Model for Simulations of Polypeptides in Aqueous Solutions
Andreas Vitalis et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2009)
Quantitative Description of Backbone Conformational Sampling of Unfolded Proteins at Amino Acid Resolution from NMR Residual Dipolar Couplings
Gabrielle Nodet et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)
Conformational selection or induced fit: A flux description of reaction mechanism
Gordon G. Hammes et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Crystal structures of the Arabidopsis thaliana proliferating cell nuclear antigen 1 and 2 proteins complexed with the human p21 C-terminal segment
Wojciech Strzalka et al.
PROTEIN SCIENCE (2009)
Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation
Clifford P. Brangwynne et al.
SCIENCE (2009)
Shaping Morphogen Gradients by Proteoglycans
Dong Yan et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2009)
Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners
Christopher J. Oldfield et al.
BMC GENOMICS (2008)
A polymeric protein anchors the chromosomal origin/ParB complex at a bacterial cell pole
Grant R. Bowman et al.
CELL (2008)
Malleable machines take shape in eukaryotic transcriptional regulation
Monika Fuxreiter et al.
NATURE CHEMICAL BIOLOGY (2008)
The enigmatic LEA proteins and other hydrophilins
Marina Battaglia et al.
PLANT PHYSIOLOGY (2008)
Contextual Specificity in Peptide-Mediated Protein Interactions
Amelie Stein et al.
PLOS ONE (2008)
Dynamic equilibrium engagement of a polyvalent ligand with a single-site receptor
Tanja Mittag et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Fuzzy complexes: polymorphism and structural disorder in protein-protein interactions
Peter Tompa et al.
TRENDS IN BIOCHEMICAL SCIENCES (2008)
Dynamic personalities of proteins
Katherine Henzler-Wildman et al.
NATURE (2007)
A saturated FG-repeat hydrogel can reproduce the permeability properties of nuclear pore complexes
Steffen Frey et al.
CELL (2007)
Mechanism of coupled folding and binding of an intrinsically disordered protein
Kenji Sugase et al.
NATURE (2007)
Polyelectrostatic interactions of disordered ligands suggest a physical basis for ultrasensitivity
Mikael Borg et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
A natively unfolded yeast prion monomer adopts an ensemble of collapsed and rapidly fluctuating structures
Samrat Mukhopadhyay et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Atomic-level characterization of disordered protein ensembles
Tanja Mittag et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2007)
Evolutionary anatomies of positions and types of disease-associated and neutral amino acid mutations in the human genome
Sankar Subramanian et al.
BMC GENOMICS (2006)
Fluorescence correlation spectroscopy shows that monomeric polyglutamine molecules form collapsed structures in aqueous solutions
Scott L. Crick et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
FG-rich repeats of nuclear pore proteins form a three-dimensional meshwork with hydrogel-like properties
Steffen Frey et al.
SCIENCE (2006)
Proline and glycine control protein self-organization into elastomeric or amyloid fibrils
Sarah Rauscher et al.
STRUCTURE (2006)
Phosphorylation and functions of the RNA polymerase IICTD
Hemali P. Phatnani et al.
GENES & DEVELOPMENT (2006)
Rules for nuclear localization sequence recognition by karyopherinβ2
Brittany J. Lee et al.
CELL (2006)
Structure of the Tfb1/p53 complex: Insights into the interaction between the p62/Tfb1 subunit of TFIIH and the activation domain of p53
Paola Di Lello et al.
MOLECULAR CELL (2006)
Conservation of intrinsic disorder in protein domains and families: I. A database of conserved predicted disordered regions
JW Chen et al.
JOURNAL OF PROTEOME RESEARCH (2006)
Conservation of intrinsic disorder in protein domains and families: II. Functions of conserved disorder
JW Chen et al.
JOURNAL OF PROTEOME RESEARCH (2006)
The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway
RP Bhattacharyya et al.
SCIENCE (2006)
Single-stranded DNA mimicry in the p53 transactivation domain interaction with replication protein A
E Bochkareva et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Crystal structure of IRF-3 in complex with CBP
BY Qin et al.
STRUCTURE (2005)
Functional correlates of mutation of the Asp32 and Gly34 residues of beta-catenin
E Provost et al.
ONCOGENE (2005)
NMR chemical shift and relaxation measurements provide evidence for the coupled folding and binding of the p53 transactivation domain
PD Vise et al.
NUCLEIC ACIDS RESEARCH (2005)
The importance of intrinsic disorder for protein phosphorylation
LM Iakoucheva et al.
NUCLEIC ACIDS RESEARCH (2004)
The role of structural disorder in the function of RNA and protein chaperones
P Tompa et al.
FASEB JOURNAL (2004)
Structural and thermodynamic analysis of human PCNA with peptides derived from DNA polymerase-δ p66 subunit and flap endonuclease-1
JB Bruning et al.
STRUCTURE (2004)
Modulation of repulsive forces between neurofilaments by sidearm phosphorylation
S Kumar et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
Mathematical modeling suggests cooperative interactions between a disordered polyvalent ligand and a single receptor site
P Klein et al.
CURRENT BIOLOGY (2003)
The C-terminal domain of the measles virus nucleoprotein is intrinsically disordered and folds upon binding to the C-terminal moiety of the phosphoprotein
S Longhi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Evolutionary rate heterogeneity in proteins with long disordered regions
CJ Brown et al.
JOURNAL OF MOLECULAR EVOLUTION (2002)
Natively unfolded proteins: A point where biology waits for physics
VN Uversky
PROTEIN SCIENCE (2002)
Coupling of folding and binding for unstructured proteins
HJ Dyson et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2002)
Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators
SJ Demarest et al.
NATURE (2002)
Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication
P Nash et al.
NATURE (2001)
Intrinsically disordered protein
AK Dunker et al.
JOURNAL OF MOLECULAR GRAPHICS & MODELLING (2001)