☆ 4.5 Article

The relationship between Alzheimer disease and thyroiditis: A two-sample Mendelian randomization study

MEDICINE (2023)

Related references

Note: Only part of the references are listed.

Article Biochemistry & Molecular Biology

The Alzheimer's gene SORL1 is a regulator of endosomal traffic and recycling in human neurons

Swati Mishra et al.

Summary: Loss of SORL1 gene affects the endosomal trafficking and recycling pathways of APP, TRKB, and GLUA1 in neurons. Increased SORL1 expression enhances these pathways. These findings highlight the importance of SORL1 in endosomal degradation and recycling in neurons and have implications for the pathology and treatment of Alzheimer's disease.

CELLULAR AND MOLECULAR LIFE SCIENCES (2022)

Add to Collection

Article Endocrinology & Metabolism

Higher thyroid function is associated with accelerated hippocampal volume loss in Alzheimer's disease

Patrick Quinlan et al.

Summary: This study found that higher thyroid hormone levels were associated with lower brain volume and increased risk of Alzheimer's disease (AD) in elderly individuals. However, the relationship between serum thyroid hormones and hippocampal atrophy rates has not been previously investigated. The results showed that FT3/FT4 ratio was related to baseline hippocampal volume in all study groups, but only in AD patients, higher levels of thyroid hormones were associated with greater annual loss of hippocampal volume.

PSYCHONEUROENDOCRINOLOGY (2022)

Add to Collection

Review Endocrinology & Metabolism

Thyroid hormones act as modulators of inflammation through their nuclear receptors

Marina Lasa et al.

Summary: The reciprocal interaction between the endocrine and immune systems is well documented, but the connection between the immune system and thyroid hormones is still unclear. This review highlights the importance of thyroid hormones in the molecular mechanisms of inflammation, particularly in various infectious and/or pathological processes. The findings suggest potential opportunities for improving therapeutic strategies for inflammation associated with infections and diseases.

FRONTIERS IN ENDOCRINOLOGY (2022)

Add to Collection

Article Psychiatry

Peripheral level of CD33 and Alzheimer's disease: a bidirectional two-sample Mendelian randomization study

Xiaojing Gu et al.

Summary: Increased peripheral expression of CD33 is causally related to the development of AD, indicating CD33 as a potential biomarker and therapeutic target for AD.

TRANSLATIONAL PSYCHIATRY (2022)

Add to Collection

Review Neurosciences

Exploring the Role ofCLUin the Pathogenesis of Alzheimer's Disease

Md Sahab Uddin et al.

Summary: CLU is a crucial factor in Alzheimer's disease development, with its increased expression level in AD patients. It plays important roles in various processes such as complement system suppression, lipid transport, and chaperone function, as well as controlling neuronal cell death and survival mechanisms. Additionally, CLU can decrease the toxicity and aggregation of amyloid beta in AD, but may not be as effective when A beta levels far exceed CLU levels.

NEUROTOXICITY RESEARCH (2021)

Add to Collection

Article Clinical Neurology

ABCA7 and the altered lipidostasis hypothesis of Alzheimer's disease

Nicholas N. Lyssenko et al.

Summary: The altered lipidostasis hypothesis of Alzheimer's disease suggests that ABCA7 plays a crucial role in protecting neurons from neurodegenerative lipid accumulation. Low levels of ABCA7 may lead to early development of AD pathology, while high levels may delay or prevent it. Further research is needed to identify the neurodegenerative lipid and explore therapeutic approaches involving ABCA7.

ALZHEIMERS & DEMENTIA (2021)

Add to Collection

Review Endocrinology & Metabolism

An update on the pathogenesis of Hashimoto's thyroiditis

A. P. Weetman

Summary: Recent studies have provided new insights into the genetic, environmental, and pathogenic mechanisms of HT, including the identification of multiple cytokine networks, various defects in T regulatory cells, and possible disease associations. Additionally, there is growing evidence suggesting a direct role of the autoimmune process in causing persistent symptoms in a subset of patients with levothyroxine-treated HT.

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION (2021)

Add to Collection

Review Immunology

Feature Review The tetraspan MS4A family in homeostasis, immunity, and disease

Irene Mattiola et al.

Summary: The MS4A family members have differential and selective expression in immunocompetent cells and modulate the signaling activity of various immunoreceptors. Studies suggest that they play key roles in different pathological settings such as cancer, infectious diseases, and neurodegeneration. Therefore, MS4A family members could be potential candidate biomarkers and therapeutic targets for various conditions.

TRENDS IN IMMUNOLOGY (2021)

Add to Collection

Article Endocrinology & Metabolism

Relationship Between Thyroid Hormone Levels and the Pathology of Alzheimer's Disease in Euthyroid Subjects

Byung Wook Choi et al.

THYROID (2020)

Add to Collection

Article Medicine, Legal

A common indel polymorphism of the Desmoglein-2 (DSG2) is associated with sudden cardiac death in Chinese populations

Yan Zou et al.

FORENSIC SCIENCE INTERNATIONAL (2019)

Add to Collection

Article Clinical Neurology

ABCA7 polymorphisms correlate with memory impairment and default mode network in patients with APOEε4-associated Alzheimer's disease

Ya-Ting Chang et al.

ALZHEIMERS RESEARCH & THERAPY (2019)

Add to Collection

Review Medicine, General & Internal

Comparison of multiple interventions for older adults with Alzheimer disease or mild cognitive impairment: A PRISMA-compliant network meta-analysis

Jing-hong Liang et al.

MEDICINE (2018)

Add to Collection

Review Clinical Neurology

Blood-based biomarkers for Alzheimer disease: mapping the road to the clinic

Harald Hampel et al.

NATURE REVIEWS NEUROLOGY (2018)

Add to Collection

Review Developmental Biology

The physical approximation of APP and BACE-1: A key event in alzheimer's disease pathogenesis

Jichao Sun et al.

DEVELOPMENTAL NEUROBIOLOGY (2018)

Add to Collection

Review Health Care Sciences & Services

A review of instrumental variable estimators for Mendelian randomization

Stephen Burgess et al.

STATISTICAL METHODS IN MEDICAL RESEARCH (2017)

Add to Collection

Article Public, Environmental & Occupational Health

Interpreting findings from Mendelian randomization using the MR-Egger method

Stephen Burgess et al.

EUROPEAN JOURNAL OF EPIDEMIOLOGY (2017)

Add to Collection

Article Neurosciences

The Retromer Supports AMPA Receptor Trafficking During LTP

Paul Temkin et al.

NEURON (2017)

Add to Collection

Article Clinical Neurology

Associations of thyroid hormone serum levels with in-vivo Alzheimer's disease pathologies

Hyo Jung Choi et al.

ALZHEIMERS RESEARCH & THERAPY (2017)

Add to Collection

Review Clinical Neurology

Nanotechnology Based Theranostic Approaches in Alzheimer's Disease Management: Current Status and Future Perspective

Javed Ahmad et al.

CURRENT ALZHEIMER RESEARCH (2017)

Add to Collection

Article Endocrinology & Metabolism

The association between subclinical thyroid dysfunction and dementia: The Health, Aging and Body Composition (Health ABC) Study

Carole E. Aubert et al.

CLINICAL ENDOCRINOLOGY (2017)

Add to Collection

Article Genetics & Heredity

Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator

Jack Bowden et al.

GENETIC EPIDEMIOLOGY (2016)

Add to Collection

Article Medicine, General & Internal

Hypothalamic-Pituitary-Thyroid Axis in Patients With Alzheimer Disease (AD)

Li Yong-Hong et al.

JOURNAL OF INVESTIGATIVE MEDICINE (2016)

Add to Collection

Article Geriatrics & Gerontology

Alzheimer's disease is associated with low density of the long CR1 isoform

Rachid Mahmoudi et al.

NEUROBIOLOGY OF AGING (2015)

Add to Collection

Article Neurosciences

The Role of PICALM in Alzheimer's Disease

Wei Xu et al.

MOLECULAR NEUROBIOLOGY (2015)

Add to Collection

Article Clinical Neurology

The prevalence of dementia in urban and rural areas of China

Jianping Jia et al.

ALZHEIMERS & DEMENTIA (2014)

Add to Collection

Article Biochemistry & Molecular Biology

Mendelian randomization: genetic anchors for causal inference in epidemiological studies

George Davey Smith et al.

HUMAN MOLECULAR GENETICS (2014)

Add to Collection

Review Neurosciences

Biological function of Presenilin and its role in AD pathogenesis

Shuting Zhang et al.

TRANSLATIONAL NEURODEGENERATION (2013)

Add to Collection

Article Neurosciences

Retromer Binds the FANSHY Sorting Motif in SorLA to Regulate Amyloid Precursor Protein Sorting and Processing

Anja W. Fjorback et al.

JOURNAL OF NEUROSCIENCE (2012)

Add to Collection

Article Multidisciplinary Sciences

Expression of Novel Alzheimer's Disease Risk Genes in Control and Alzheimer's Disease Brains

Celeste M. Karch et al.

PLOS ONE (2012)

Add to Collection

Article Psychology, Clinical

Occurrence of neuropsychiatric symptoms and psychiatric disorders in mild Alzheimer's disease and mild cognitive impairment subtypes

Fulvia Di Iulio et al.

INTERNATIONAL PSYCHOGERIATRICS (2010)

Add to Collection

Review Neurosciences

Synapse development and plasticity: roles of ephrin/Eph receptor signaling

Kwok-On Lai et al.

CURRENT OPINION IN NEUROBIOLOGY (2009)

Add to Collection

Review Mathematical & Computational Biology

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

Debbie A. Lawlor et al.

STATISTICS IN MEDICINE (2008)

Add to Collection

Article Clinical Neurology

Thyroid function in patients with Alzheimer disease: Implications on response to anticholinesterase treatment

Elisabeth Kapaki et al.

ALZHEIMER DISEASE & ASSOCIATED DISORDERS (2006)

Add to Collection

Article Neurosciences

Disruption of ephrin-A/EphA binding alters synaptogenesis and neural connectivity in the hippocampus

A Martinez et al.

NEUROSCIENCE (2005)

Add to Collection

Article Medicine, General & Internal

Thyroid status, disability and cognitive function, and survival in old age

J Gussekloo et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2004)

Add to Collection

Article Neurosciences

Thyrotropin releasing hormone (TRH) in the hippocampus of Alzheimer patients

LuGuang Luo et al.

JOURNAL OF ALZHEIMERS DISEASE (2002)

Add to Collection

© Peeref 2019-2024. All rights reserved.