☆ 4.5 Article

Integrin αvβ1 facilitates ACE2-mediated entry of SARS-CoV-2

VIRUS RESEARCH (2024)

Related references

Note: Only part of the references are listed.

Article Biochemistry & Molecular Biology

Receptor-binding domain of SARS-CoV-2 is a functional αv-integrin agonist

Emma G. Norris et al.

Summary: Among the mutations of SARS-CoV-2, a K403R substitution in the receptor-binding domain (RBD) of the viral spike protein has been identified. This substitution leads to the presence of an RGD adhesion motif, similar to fibronectin, and allows S1-RBD to bind to cell surface integrins and trigger downstream signaling pathways. This study reveals the potential role of S1-mediated dysregulation of extracellular matrix dynamics in the pathogenesis and post-acute sequelae of SARS-CoV-2 infection.

JOURNAL OF BIOLOGICAL CHEMISTRY (2023)

Add to Collection

Article Biochemistry & Molecular Biology

Integrin mediates cell entry of the SARS-CoV-2 virus independent of cellular receptor ACE2

Jiamnin Liu et al.

Summary: This study reveals that SARS-CoV-2 can enter cells not only by binding to ACE2 through its spike protein, but also by binding to integrin alpha 5 beta 1. The activation of integrin plays a critical role in facilitating the internalization of SARS-CoV-2 into non-ACE2 cells. This alternative pathway for cell entry may contribute to the further infection and progression of COVID-19.

JOURNAL OF BIOLOGICAL CHEMISTRY (2022)

Add to Collection

Article Biochemistry & Molecular Biology

The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin α5β1 and NF-κB signaling

Juan Pablo Robles et al.

Summary: COVID-19 causes dysfunction of vascular endothelial cells, leading to edema, vascular inflammation, and coagulation. This study reveals that the spike protein of SARS-CoV-2 activates the inflammatory response in endothelial cells through binding with integrin alpha 5 beta 1, resulting in the expression of inflammatory and coagulation factors, as well as increased vascular permeability and leukocyte adhesion. These findings highlight integrin alpha 5 beta 1 as a potential target for treating vascular inflammation in COVID-19.

JOURNAL OF BIOLOGICAL CHEMISTRY (2022)

Add to Collection

Article Immunology

AZD1222 (ChAdOx1 nCov-19): A Single-Dose biodistribution study in mice

Richard Stebbings et al.

Summary: Biodistribution studies showed that AZD1222 vaccine had limited spread in mice, mainly confined to the administration sites and the proximal sciatic nerve, with low levels observed in sites involved in rapid clearance. The levels of AZD1222 decreased from Day 2 to Day 29, indicating clearance. No measurable levels of AZD1222 were found in the blood, brain, spinal cord, and reproductive tissue, suggesting a lack of widespread or long-term distribution of AZD1222 vector DNA in the body.

VACCINE (2022)

Add to Collection

Review Immunology

Response to SARS-CoV-2 vaccination in immune mediated inflammatory diseases: Systematic review and meta-analysis

Anuraag Jena et al.

Summary: The treatment for COVID-19 often involves immune-modulating drugs, which are also used in immune mediated inflammatory diseases (IMIDs). This systematic review examines the seroconversion after SARS-CoV-2 vaccination in patients with IMIDs and the impact of different drugs on seroconversion rates. The findings suggest that patients with IMIDs have lower seroconversion rates, and certain therapies have no impact on seroconversion rates while others result in poorer responses.

AUTOIMMUNITY REVIEWS (2022)

Add to Collection

Article Virology

SARS-CoV-2 Infects Human ACE2-Negative Endothelial Cells through an αvβ3 Integrin-Mediated Endocytosis Even in the Presence of Vaccine-Elicited Neutralizing Antibodies

Antonella Bugatti et al.

Summary: Integrins serve as a gateway for SARS-CoV-2 to enter lung endothelial cells, promoting angiogenesis. Alpha(v)beta(3) integrin is identified as the key molecule responsible for this infection. Vaccination-induced antibodies do not inhibit the interaction between SARS-CoV-2 and integrins.

VIRUSES-BASEL (2022)

Add to Collection

Article Chemistry, Medicinal

Integrin/TGF-β1 Inhibitor GLPG-0187 Blocks SARS-CoV-2 Delta and Omicron Pseudovirus Infection of Airway Epithelial Cells In Vitro, Which Could Attenuate Disease Severity

Kelsey E. Huntington et al.

Summary: As COVID-19 continues to pose a major risk to vulnerable populations, novel treatment strategies are urgently needed. This study demonstrates that the pan-integrin inhibitor GLPG-0187 effectively blocks SARS-CoV-2 pseudovirus infection, particularly of the Omicron and Delta variants. Additionally, inhibiting integrin signaling may mitigate COVID-19 severity by decreasing activation of TGF-beta 1.

PHARMACEUTICALS (2022)

Add to Collection

Article Multidisciplinary Sciences

SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling

Scott B. Biering et al.

Summary: Severe COVID-19 is characterized by barrier dysfunction in the lung and distal organs. Researchers have discovered that the spike glycoprotein of SARS-CoV-2 can interact with epithelial/endothelial cells, leading to barrier dysfunction and vascular leak. Further investigation has revealed that this phenomenon is associated with extracellular matrix reorganization and TGF-beta signaling. It has also been found that glycosaminoglycans, integrins, and the TGF-beta signaling pathway play critical roles in S-mediated barrier dysfunction.

NATURE COMMUNICATIONS (2022)

Add to Collection

Article Multidisciplinary Sciences

ACE2 protein expression in lung tissues of severe COVID-19 infection

Atish Gheware et al.

Summary: This study found significantly higher ACE2 protein expression in the lung tissues of deceased COVID-19 patients, which correlated with pathological changes and disease severity.

SCIENTIFIC REPORTS (2022)

Add to Collection

Article Cell Biology

AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells

Shuai Wang et al.

Summary: This study found that AXL may serve as a novel receptor for SARS-CoV-2, playing an important role in promoting viral infection of the human respiratory system. AXL expression level is closely correlated with SARS-CoV-2 S level and could be a potential target for future clinical intervention strategies.

CELL RESEARCH (2021)

Add to Collection

Article Immunology

SARS-CoV-2 attachment to host cells is possibly mediated via RGD-integrin interaction in a calcium-dependent manner and suggests pulmonary EDTA chelation therapy as a novel treatment for COVID 19

Tikam Chand Dakal

Summary: The study suggests that SARS-CoV-2 may exploit integrins, particularly those with high expression in lungs and vital organs, via the RGD motif for invading host cells, potentially explaining its higher infectivity. This alternate receptor theory contrasts with the traditional ACE2 receptor, and experimental verification is needed to confirm the findings.

IMMUNOBIOLOGY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Cytoplasmic short linear motifs in ACE2 and integrin β3 link SARS-CoV-2 host cell receptors to mediators of endocytosis and autophagy

Johanna Kliche et al.

Summary: The spike protein of SARS-CoV-2 binds ACE2 and integrin on host cells, with cytoplasmic tails containing motifs that facilitate internalization of the virus. The study validated interactions between ACE2 and integrin with proteins involved in endocytic trafficking and autophagy, providing molecular links between cell receptors and virus propagation through internal processes.

SCIENCE SIGNALING (2021)

Add to Collection

Review Virology

Biological and Clinical Consequences of Integrin Binding via a Rogue RGD Motif in the SARS CoV-2 Spike Protein

Lee Makowski et al.

Summary: This paper proposes the hypothesis that viral binding to cell-surface integrins may contribute to the high infectivity and widespread extra-pulmonary impacts of SARS-CoV-2. The emergence of an RGD sequence in the receptor-binding domain of the spike protein is suggested to be potentially responsible for this. The interactions between virions and integrins could dysregulate signaling pathways and lead to tissue damage, with implications for various clinical outcomes.

VIRUSES-BASEL (2021)

Add to Collection

Letter Infectious Diseases

Low incidence rate of diarrhoea in COVID-19 patients is due to integrin

Shan Gao et al.

JOURNAL OF INFECTION (2021)

Add to Collection

Article Medicine, Research & Experimental

In Vivo protection from SARS-CoV-2 infection by ATN-161 in k18-hACE2 transgenic mice

Narayanappa Amruta et al.

Summary: The study demonstrates the potential therapeutic efficacy of targeting integrin alpha 5β1 with the small peptide ATN-161 in vivo for SARS-CoV-2 infection. Treatment with ATN-161 significantly reduces lung viral load, viral immunofluorescence, and improves lung histology post-infection, indicating its potential as a novel therapy for SARS-CoV-2.

LIFE SCIENCES (2021)

Add to Collection

Article Multidisciplinary Sciences

Nonmuscle myosin heavy chain IIA facilitates SARS-CoV-2 infection in human pulmonary cells

Jian Chen et al.

Summary: The study identified MYH9 as an important host factor for SARS-CoV-2 infection of human pulmonary cells, mediating viral entry through endocytosis and bypassing the TMPRSS2 and CatB/L pathways. Loss of MYH9 reduces authentic SARS-CoV-2 infection in ACE2-expressing cells, suggesting it as a potential target for clinical intervention strategies in the future.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Add to Collection

Article Multidisciplinary Sciences

Integrin activation is an essential component of SARS-CoV-2 infection

Peter Simons et al.

Summary: SARS-CoV-2 infection relies on the binding of its spike protein to ACE2, with integrins potentially acting as co-receptors. Integrins play a crucial role in mediating cell entry and infection, with talin-mediated signaling being essential for the productive infection process.

SCIENTIFIC REPORTS (2021)

Add to Collection

Article Virology

The Spike Glycoprotein of SARS-CoV-2 Binds to β1 Integrins Expressed on the Surface of Lung Epithelial Cells

Eun Jeong Park et al.

Summary: Experimental evidence shows that beta 1 integrins, predominantly expressed on human pulmonary epithelial cells and primary mouse alveolar epithelial cells, can bind to the spike protein of SARS-CoV-2 independently of ACE2, suggesting the possibility that beta 1 integrins may serve as an alternative receptor for the virus and could be a target for prevention of viral infections.

VIRUSES-BASEL (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Role of host factors in SARS-CoV-2 entry

John P. Evans et al.

Summary: This article discusses the factors governing the entry of SARS-CoV-2 into cells, focusing on the viral spike protein, host proteases, host cofactors, and host restriction factors. The unique features of SARS-CoV-2 in comparison to other human coronaviruses are highlighted, along with the gaps in understanding that require further research.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

Add to Collection

Article Multidisciplinary Sciences

SARS-CoV-2 uses major endothelial integrin αvβ3 to cause vascular dysregulation in-vitro during COVID-19

Danielle Nader et al.

Summary: The unprecedented global COVID-19 pandemic has led to an urgent international effort to accelerate the development of antiviral drugs. COVID-19 infections are associated with cardiovascular complications, highlighting the importance of vascular endothelial cells in viral propagation. The etiological pathogen, SARS-CoV-2, possesses novel characteristics that enhance transmissibility, potentially through the integrin alpha V beta 3.

PLOS ONE (2021)

Add to Collection

Article Multidisciplinary Sciences

ELV-N32 and RvD6 isomer decrease pro-inflammatory cytokines, senescence programming, ACE2 and SARS-CoV-2-spike protein RBD binding in injured cornea

Thang L. Pham et al.

Summary: The study found that lipid mediators ELV-N32 and RvD6i can reduce the expression of the ACE2 receptor, furin, and integrins in damaged corneas or IFN-γ-stimulated HCEC, as well as decrease the binding of Spike protein. This indicates a potential for lipid mediators to help counteract virus attachment and entry into the body.

SCIENTIFIC REPORTS (2021)

Add to Collection

Article Microbiology

SARS-CoV-2 Infection Remodels the Phenotype and Promotes Angiogenesis of Primary Human Lung Endothelial Cells

Francesca Caccuri et al.

Summary: The study demonstrated the capability of SARS-CoV-2 to infect human lung microvascular endothelial cells and release pro-inflammatory and pro-angiogenic molecules, leading to angiogenic phenotype in these cells. Proteome analysis confirmed the remodeling of these cells towards inflammatory and angiogenic responses.

MICROORGANISMS (2021)

Add to Collection

Article Cardiac & Cardiovascular Systems

The Integrin Binding Peptide, ATN-161, as a Novel Therapy for SARS-CoV-2 Infection

Brandon J. Beddingfield et al.

Summary: Efforts to design therapeutics for the current SARS-CoV-2 pandemic have focused on inhibiting viral host cell entry by disrupting ACE2 binding. This study suggests that inhibiting viral entry through the alpha 5 beta 1 integrin mechanism using ATN-161 may be a promising approach for treating COVID-19.

JACC-BASIC TO TRANSLATIONAL SCIENCE (2021)

Add to Collection

Article Immunology

The in vitro antiviral activity of lactoferrin against common human coronaviruses and SARS-CoV-2 is mediated by targeting the heparan sulfate co-receptor

Yanmei Hu et al.

Summary: The study highlights the important role of HSPGs in SARS-CoV-2 cell attachment, and demonstrates the broad-spectrum antiviral activity of LF against various coronaviruses, especially with BLF being more potent than HLF. BLF binds to HSPGs to block viral attachment, and its antiviral activity can be antagonized by the HSPG mimetic heparin. Combination therapy experiment shows synergistic effect of LF with remdesivir in cell culture.

EMERGING MICROBES & INFECTIONS (2021)

Add to Collection

Article Pharmacology & Pharmacy

A potential role for integrins in host cell entry by SARS-CoV-2

Christian J. A. Sigrist et al.

ANTIVIRAL RESEARCH (2020)

Add to Collection

Article Microbiology

A Mouse Model of SARS-CoV-2 Infection and Pathogenesis

Shi-Hui Sun et al.

CELL HOST & MICROBE (2020)

Add to Collection

Letter Infectious Diseases

A potential inhibitory role for integrin in the receptor targeting of SARS-CoV-2

Junwen Luan et al.

JOURNAL OF INFECTION (2020)

Add to Collection

Article Medicine, General & Internal

Multiorgan and Renal Tropism of SARS-CoV-2

Victor G. Puelles et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Add to Collection

Editorial Material Pharmacology & Pharmacy

New Strategy for COVID-19: An Evolutionary Role for RGD Motif in SARS-CoV-2 and Potential Inhibitors for Virus Infection

Shijia Yan et al.

FRONTIERS IN PHARMACOLOGY (2020)

Add to Collection

Article Multidisciplinary Sciences

Enhanced receptor binding of SARS-CoV-2 through networks of hydrogen-bonding and interactions

Yingjie Wang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Add to Collection

Article Multidisciplinary Sciences

Structures and distributions of SARS-CoV-2 spike proteins on intact virions

Zunlong Ke et al.

NATURE (2020)

Add to Collection

Article Multidisciplinary Sciences

Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity

Ludovico Cantuti-Castelvetri et al.

SCIENCE (2020)

Add to Collection

Letter Clinical Neurology

Covid-19 in a patient with multiple sclerosis treated with natalizumab: May the blockade of integrins have a protective role?

Clara Aguirre et al.

MULTIPLE SCLEROSIS AND RELATED DISORDERS (2020)

Add to Collection

Review Respiratory System

ACE2: The Major Cell Entry Receptor for SARS-CoV-2

Filippo Scialo et al.

LUNG (2020)

Add to Collection

Article Cardiac & Cardiovascular Systems

Dynamic Regulation of SARS-Cov-2 Binding and Cell Entry Mechanisms in Remodeled Human Ventricular Myocardium

Michael R. Bristow et al.

JACC-BASIC TO TRANSLATIONAL SCIENCE (2020)

Add to Collection

Article Biochemistry & Molecular Biology

SWISS-MODEL: homology modelling of protein structures and complexes

Andrew Waterhouse et al.

NUCLEIC ACIDS RESEARCH (2018)

Add to Collection

Article Multidisciplinary Sciences

Identification of sialic acid-binding function for the Middle East respiratory syndrome coronavirus spike glycoprotein

Wentao Li et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Add to Collection

Article Multidisciplinary Sciences

Rules of engagement between αvβ6 integrin and foot-and-mouth disease virus

Abhay Kotecha et al.

NATURE COMMUNICATIONS (2017)

Add to Collection

Review Virology

Beyond RGD: virus interactions with integrins

Hosni A. M. Hussein et al.

ARCHIVES OF VIROLOGY (2015)

Add to Collection

Review Pharmacology & Pharmacy

The MM/PBSA and MM/GBSA methods to estimate ligand-binding affinities

Samuel Genheden et al.

EXPERT OPINION ON DRUG DISCOVERY (2015)

Add to Collection

Article Biotechnology & Applied Microbiology

Assembly and characterization of foot-and-mouth disease virus empty capsid particles expressed within mammalian cells

Maria Gullberg et al.

JOURNAL OF GENERAL VIROLOGY (2013)

Add to Collection

Article Biochemistry & Molecular Biology

Computer-aided drug design platform using PyMOL

Markus A. Lill et al.

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2011)

Add to Collection

Article Cell Biology

Integrin Structure, Activation, and Interactions

Iain D. Campbell et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2011)

Add to Collection

Article Biochemical Research Methods

The HADDOCK web server for data-driven biomolecular docking

Sjoerd J. De Vries et al.

NATURE PROTOCOLS (2010)

Add to Collection

Article Biochemical Research Methods

I-TASSER: a unified platform for automated protein structure and function prediction

Ambrish Roy et al.

NATURE PROTOCOLS (2010)

Add to Collection

Article Immunology

HIV-1 envelope protein binds to and signals through integrin α4β7, the gut mucosal homing receptor for peripheral T cells

James Arthos et al.

NATURE IMMUNOLOGY (2008)

Add to Collection

Article Biochemistry & Molecular Biology

Bcl-xL inhibits T-cell apoptosis induced by expression of SARS coronavirus E protein in the absence of growth factors

Y Yang et al.

BIOCHEMICAL JOURNAL (2005)

Add to Collection

Article Biochemistry & Molecular Biology

Integrin αvβ3 is a coreceptor for human cytomegalovirus

X Wang et al.

NATURE MEDICINE (2005)

Add to Collection

Article Multidisciplinary Sciences

Cellular integrins function as entry receptors for human cytomegalovirus via a highly conserved disintegrin-like domain

AL Feire et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Add to Collection

Review Biochemistry & Molecular Biology

Integrins: Bidirectional, allosteric signaling machines

RO Hynes

CELL (2002)

Add to Collection

© Peeref 2019-2024. All rights reserved.