Journal
ARCHIVES OF ORAL BIOLOGY
Volume 157, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.archoralbio.2023.105825
Keywords
Seaweed; Periodontal disease; Inflammation
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This study investigates the effects of D. anceps seaweed on ligature-induced experimental periodontitis in rats. The results show that D. anceps can modulate the inflammatory response and have potential therapeutic effects for periodontitis.
Objective: Desmarestia anceps Montagne (D. anceps) seaweed has been shown to play a range of biologic activities, such as anti-inflammatory and antioxidant properties. The purpose of this study was to investigate the effects of D. anceps on pathogenesis of ligature-induced experimental periodontitis in rats. Design: Fifty-four male Wistar rats were randomly divided into six groups. Doses of D. anceps (100 and 200 mg/ kg) were administered for 14 days to animals with or without ligature-induced periodontitis, in order to compare to control groups (vehicle solution). Morphometric registration of alveolar bone loss and histological analysis were conducted. Inflammatory cells were counted on hematoxylin-eosin-stained slides. Immunohistochemical expressions for interleukin-1 beta (IL-1 beta), tumor necrosis factor (TNF-alpha), receptor activator of nuclear factor kappa-B ligand (RANKL) and bone morphogenetic protein 2 (BMP-2) were evaluated. Results: Alveolar bone loss was higher in groups exposed to ligature-induced periodontitis, but no significant differences were observed comparing different treatment and control groups. Animals that received D. anceps extracts showed significant lower counts of inflammatory cells. D. anceps promoted increased expression of BMP2 and inhibited IL-1 beta, TNF-alpha and RANKL. Conclusion: D. anceps modulates inflammatory response in experimental periodontitis in rats. Further pharmacological and immunological analyses are warranted.
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