4.0 Article

Revisiting incidence rates comparison under right censorship

Journal

INTERNATIONAL JOURNAL OF BIOSTATISTICS
Volume -, Issue -, Pages -

Publisher

WALTER DE GRUYTER GMBH
DOI: 10.1515/ijb-2023-0025

Keywords

hypothesis testing; incidence rates; person-time; right-censorship; two-sample comparison

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Data description is the first step in understanding the nature of the problem. This research revisits the incidence rate estimator under right-censorship and analyzes its impact on observed results. A solution is proposed to limit the impact of data collection on hypothesis testing results.
Data description is the first step for understanding the nature of the problem at hand. Usually, it is a simple task that does not require any particular assumption. However, the interpretation of the used descriptive measures can be a source of confusion and misunderstanding. The incidence rate is the quotient between the number of observed events and the sum of time that the studied population was at risk of having this event (person-time). Despite this apparently simple definition, its interpretation is not free of complexity. In this piece of research, we revisit the incidence rate estimator under right-censorship. We analyze the effect that the censoring time distribution can have on the observed results, and its relevance in the comparison of two or more incidence rates. We propose a solution for limiting the impact that the data collection process can have on the results of the hypothesis testing. We explore the finite-sample behavior of the considered estimators from Monte Carlo simulations. Two examples based on synthetic data illustrate the considered problem. The R code and data used are provided as Supplementary Material.

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