Daytime napping, biological aging and cognitive function among middle-aged and older Chinese: insights from the China health and retirement longitudinal study

Article Clinical Neurology

Daytime napping and Alzheimer's dementia: A potential bidirectional relationship

Peng Li et al.

Summary: Daytime napping is common in older adults and is associated with Alzheimer's disease. The relationship between daytime napping and cognitive aging is bidirectional.

ALZHEIMERS & DEMENTIA (2023)

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Article Geriatrics & Gerontology

Longitudinal associations between daytime napping and cognitive function in Chinese older adults

Lijuan Zhang et al.

Summary: This study found a longitudinal association between extended napping duration and worse cognitive function. Using data from the China Health and Retirement Longitudinal Study (CHARLS), the study observed that in the elderly population, not napping and extended napping were significantly associated with global cognitive decline as well as decline in episodic memory and mental status.

ARCHIVES OF GERONTOLOGY AND GERIATRICS (2023)

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Article Geriatrics & Gerontology

Genetic Evidence for Causal Effects of Socioeconomic, Lifestyle, and Cardiometabolic Factors on Epigenetic-Age Acceleration

Lijie Kong et al.

Summary: This study identifies modifiable risk factors for accelerated epigenetic aging and provides promising intervention targets against age-related morbidity. Smoking is the strongest risk factor, while education is the strongest protective factor. These findings offer novel quantitative evidence for improving healthy longevity.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2023)

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Article Geriatrics & Gerontology

Association of lifestyle with mortality and the mediating role of aging among older adults in China

Shuyi Jin et al.

Summary: The study found that in the older Chinese population, a healthy lifestyle decreases the risk of mortality, with aging partially mediating this association.

ARCHIVES OF GERONTOLOGY AND GERIATRICS (2022)

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Article Cell Biology

Role of sleep quality in the acceleration of biological aging and its potential for preventive interaction on air pollution insults: Findings from the UK Biobank cohort

Xu Gao et al.

Summary: This study examines the associations between sleep behaviors and biological ages, and finds that improving sleep quality can mitigate accelerated biological aging caused by air pollution.

AGING CELL (2022)

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Article Geriatrics & Gerontology

Bidirectional relationship between nocturnal subjective sleep duration and cognitive performance in Chinese over 45 years old: a national representative longitudinal study

Chao Li et al.

Summary: This study found bidirectional associations between sleep duration and cognitive function, with different effects at the interindividual and intraindividual levels. Longer subjective nocturnal sleep duration predicted better cognitive performance for short sleepers, but prolonged subjective nocturnal sleep duration led to later cognitive decline for moderate and long sleepers.

BMC GERIATRICS (2022)

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Review Medicine, Research & Experimental

Biological aging processes underlying cognitive decline and neurodegenerative disease

Mitzi M. Gonzales et al.

Summary: This review provides an overview of the development of ADRD and the relationship between age-related cognitive decline and neurodegenerative changes, highlighting aging processes differentially regulated in neurodegenerative disease. Targeting fundamental processes underlying biological aging may represent a novel avenue to attenuate the development of ADRD.

JOURNAL OF CLINICAL INVESTIGATION (2022)

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Article Biochemistry & Molecular Biology

Brain-age in midlife is associated with accelerated biological aging and cognitive decline in a longitudinal birth cohort

Maxwell L. Elliott et al.

Summary: BrainAGE, a measure of the difference between predicted age from brain-imaging data and chronological age, has been proposed as a biomarker for age-related brain deterioration. Studies suggest that individuals with older brainAGEs may be more susceptible to Alzheimer's, dementia, and mortality, but further research is needed to validate its effectiveness.

MOLECULAR PSYCHIATRY (2021)

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Article Geriatrics & Gerontology

Development and Validation of 2 Composite Aging Measures Using Routine Clinical Biomarkers in the Chinese Population: Analyses From 2 Prospective Cohort Studies

Zuyun Liu

Summary: This study aimed to develop and validate two composite aging measures in the Chinese population. The results showed that these measures were associated with mortality and disease counts, demonstrating potential applications in early identification and prevention of aging-related issues in China.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2021)

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Article Medicine, General & Internal

Different hypertension thresholds and cognitive decline: a pooled analysis of three ageing cohorts

Yanjun Ma et al.

Summary: A comparison of cognitive decline trajectories between individuals with borderline hypertension and normal blood pressure showed no significant difference in decline rate, while those with high blood pressure exhibited significantly faster cognitive decline. Individuals with borderline hypertension may not need to start antihypertensive therapy considering cognitive decline.

BMC MEDICINE (2021)

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Article Clinical Neurology

Sleep, inflammation and cognitive function in middle-aged and older adults: A population-based study

Mingyue Hu et al.

Summary: A study found that nighttime sleep of 6.1-7 hours and afternoon napping of less than 30 minutes are associated with optimal cognitive function in middle-aged and older individuals. The inflammatory profile partly influences how sleep affects cognition.

JOURNAL OF AFFECTIVE DISORDERS (2021)

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Article Geriatrics & Gerontology

A toolkit for quantification of biological age from blood chemistry and organ function test data: BioAge

Dayoon Kwon et al.

Summary: Methods for quantifying biological aging are becoming important tools in epidemiology and population science. While DNA methylation-based measures have been rapidly disseminated, biological age measures derived from blood chemistry data have shown superior performance in predicting healthy lifespan. However, the dissemination of these measures has been slower, resulting in a significant knowledge gap. The BioAge R package was developed to facilitate the measurement of biological age for geroscience research, offering users the ability to quantify biological aging based on analysis of chronological age and mortality risk. Results from using the BioAge toolkit in the CALERIE trial suggest that intervention can slow biological aging.

GEROSCIENCE (2021)

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Article Cell Biology

Genetic associations for two biological age measures point to distinct aging phenotypes

Chia-Ling Kuo et al.

Summary: Biological age measures outperform chronological age in predicting aging outcomes, with genetic predisposition being most strongly associated with the APOE gene. Different biological age measures show unique genetic associations and pathway enrichments, indicating they capture distinct aging domains.

AGING CELL (2021)

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Article Multidisciplinary Sciences

Biological age in healthy elderly predicts aging-related diseases including dementia

Julia W. Wu et al.

Summary: The study demonstrates that accelerated biological age is a predictor of major age-related morbidity, including dementia, among healthy elderly individuals. Additionally, microRNAs were found to be significantly associated with age, with top differentially expressed microRNAs based on biological age having a higher significance level, suggesting that biological age captures aspects of aging signals at the epigenetic level.

SCIENTIFIC REPORTS (2021)

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Article Medicine, General & Internal

Association Between Sleep Duration and Cognitive Decline

Yanjun Ma et al.

JAMA NETWORK OPEN (2020)

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Article Geriatrics & Gerontology

Physiological Dysregulation as a Promising Measure of Robustness and Resilience in Studies of Aging and a New Indicator of Preclinical Disease

Konstantin G. Arbeev et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2019)

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Article Clinical Neurology

Objective napping, cognitive decline, and risk of cognitive impairment in older men

Yue Leng et al.

ALZHEIMERS & DEMENTIA (2019)

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Article Cardiac & Cardiovascular Systems

Cognitive Decline Before and After Incident Coronary Events

Wuxiang Xie et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2019)

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Article Geriatrics & Gerontology

Napping characteristics and cognitive performance in older adults

Jocelynn T. Owusu et al.

INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY (2019)

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Article Public, Environmental & Occupational Health

Early life exposure to China's 1959-61 famine and midlife cognition

Hongwei Xu et al.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2018)

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Article Geriatrics & Gerontology

Intermediate, But Not Extended, Afternoon Naps May Preserve Cognition in Chinese Older Adults

Junxin Li et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2018)

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Article Endocrinology & Metabolism

HbA1c, diabetes and cognitive decline: the English Longitudinal Study of Ageing

Fanfan Zheng et al.

DIABETOLOGIA (2018)

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Association of postlunch napping duration and night-time sleep duration with cognitive impairment in Chinese elderly: a cross-sectional study

Jun-Fen Lin et al.

BMJ OPEN (2018)

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Article Public, Environmental & Occupational Health

Eleven Telomere, Epigenetic Clock, and Biomarker-Composite Quantifications of Biological Aging: Do They Measure the Same Thing?

Daniel W. Belsky et al.

AMERICAN JOURNAL OF EPIDEMIOLOGY (2018)

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Article Geriatrics & Gerontology

Afternoon Napping and Cognition in Chinese Older Adults: Findings from the China Health and Retirement Longitudinal Study Baseline Assessment

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JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2017)

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Heterogeneity of Human Aging and Its Assessment

Arnold Mitnitski et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2017)

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Review Medicine, General & Internal

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LANCET (2017)

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Article Multidisciplinary Sciences

Quantification of biological aging in young adults

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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Editorial Material Biochemistry & Molecular Biology

Geroscience: Linking Aging to Chronic Disease

Brian K. Kennedy et al.

CELL (2014)

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Article Public, Environmental & Occupational Health

Cohort Profile: The China Health and Retirement Longitudinal Study (CHARLS)

Yaohui Zhao et al.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2014)

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Article Psychology, Clinical

Factorial validity of the Center for Epidemiologic Studies Depression Scale short form in older population in China

Huajuan Chen et al.

INTERNATIONAL PSYCHOGERIATRICS (2014)

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Correction Clinical Neurology

Potential for primary prevention of Alzheimer's disease: an analysis of population-based data (vol 13, pg 788, 2014)

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LANCET NEUROLOGY (2014)

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Potential for primary prevention of Alzheimer's disease: an analysis of population-based data

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Modeling the Rate of Senescence: Can Estimated Biological Age Predict Mortality More Accurately Than Chronological Age?

Morgan E. Levine

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2013)

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Article Cell Biology

A novel statistical approach shows evidence for multi-system physiological dysregulation during aging

Alan A. Cohen et al.

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Daytime napping, biological aging and cognitive function among middle-aged and older Chinese: insights from the China health and retirement longitudinal study

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