4.5 Article

Suppresses of LIM kinase 2 promotes radiosensitivity in radioresistant non-small cell lung cancer cells

Related references

Note: Only part of the references are listed.
Article Pharmacology & Pharmacy

Inhibition of LIM kinase reduces contraction and proliferation in bladder smooth muscle

Qingfeng Yu et al.

Summary: The study found that LIMKs kinase expression is elevated in OAB rat bladder tissues, and LIMK inhibitors can effectively inhibit bladder smooth muscle contraction and proliferation, potentially serving as a therapeutic strategy for OAB-related LUTS.

ACTA PHARMACEUTICA SINICA B (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Oncology

Cancer-associated fibroblasts promote the survival of irradiated nasopharyngeal carcinoma cells via the NF-κB pathway

Weiqiang Huang et al.

Summary: The study revealed that cancer-associated fibroblasts (CAFs) infiltrated in radiation-resistant NPC tissues induced radioresistance and promoted NPC cell survival post-irradiation via the IL-8/NF-κB pathway. Treatment with Tranilast, a CAF inhibitor, restricted the survival of CAF-induced NPC cells and alleviated radioresistance properties, suggesting the potential value of Tranilast in sensitizing NPC cells to irradiation.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2021)

Article Cell Biology

LYAR Promotes Colorectal Cancer Progression by Upregulating FSCN1 Expression and Fatty Acid Metabolism

Yupeng Wu et al.

Summary: This study revealed a novel mechanism by which LYAR promotes tumor cell migration and invasion by upregulating FSCN1 expression and affecting fatty acid metabolism in CRC.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

Article Chemistry, Multidisciplinary

THOC2 and THOC5 Regulate Stemness and Radioresistance in Triple-Negative Breast Cancer

Xupeng Bai et al.

Summary: The study shows that THOC2 and THOC5 are upregulated in radioresistant TNBC cells, promoting stem-like properties and radioresistance. Silencing THOC2 or THOC5 expression decreases protein expression of SOX2 and NANOG, depletes stem-like properties, and causes radiosensitization in TNBC cells. Depletion of THOC2 or THOC5 blocks xenograft tumorigenesis and growth of radioresistant TNBC in vivo, suggesting potential therapeutic strategies against relapsed TNBC.

ADVANCED SCIENCE (2021)

Review Oncology

The abscopal effect of radiation therapy

Daniel J. Craig et al.

Summary: Radiation therapy can induce a systemic anticancer response by promoting immune activation. Enhancing T-cell activity through immunotherapeutic drugs can further augment this effect. The presence of tumor infiltrating lymphocytes and specific signal expression may serve as prognostic biomarkers.

FUTURE ONCOLOGY (2021)

Article Oncology

Radiotherapy programs neutrophils to an antitumor phenotype by inducing mesenchymal-epithelial transition

Qiqi Liu et al.

Summary: The study demonstrated that radiation therapy can trigger the recruitment and polarization of neutrophils towards an anti-tumor phenotype, which is further enhanced by concurrent administration of G-CSF. Furthermore, neutrophils newly recruited after radiation therapy are shown to improve radiosensitivity by inhibiting epithelial-mesenchymal transition via the reactive oxygen species-mediated PI3K/Akt/Snail signaling pathway.

TRANSLATIONAL LUNG CANCER RESEARCH (2021)

Article Oncology

Radiation Therapy-Associated Toxicity: Etiology, Management, and Prevention

Kyle Wang et al.

Summary: Radiation therapy is an effective treatment for malignancies but can cause toxicity in surrounding organs and tissues. The manifestation of side effects depends on cellular characteristics and the anatomy and physiology of affected organs. Technological advances have improved the ability to deliver radiation therapy while minimizing toxicity, making the study of side effects an important aspect of cancer management.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Oncology

IL-11 mediates the Radioresistance of Cervical Cancer Cells via the PI3K/Akt Signaling Pathway

Ruige Sun et al.

Summary: IL-11 is upregulated in cervical cancer tissues and associated with clinical stages and poor prognosis. Knocking down IL-11 can reduce radioresistance in Hela cells, while exogeneous IL-11 can confer radioresistance in C33A cells, potentially through the activation of the PI3K/Akt signaling pathway. Therefore, IL-11 may be a promising target for radiosensitization in cervical cancer therapy.

JOURNAL OF CANCER (2021)

Article Oncology

UBE2T-regulated H2AX monoubiquitination induces hepatocellular carcinoma radioresistance by facilitating CHK1 activation

Jingyuan Sun et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

Article Oncology

Targeting HMGB3/hTERT axis for radioresistance in cervical cancer

Zongjuan Li et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

Article Oncology

The JAK2/STAT3/CCND2 Axis promotes colorectal Cancer stem cell persistence and radioresistance

So-Yeon Park et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

Article Oncology

Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress

Jennifer Port et al.

CANCER DISCOVERY (2018)

Article Biochemistry & Molecular Biology

Radiotherapy induces responses of lung cancer to CTLA-4 blockade

Silvia C. Formenti et al.

NATURE MEDICINE (2018)

Article Biochemistry & Molecular Biology

Lim kinases, regulators of actin dynamics

Ora Bernard

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2007)

Article Biochemical Research Methods

Clonogenic assay of cells in vitro

Nicolaas A. P. Franken et al.

NATURE PROTOCOLS (2006)