4.7 Article

HDL-Related Parameters and COVID-19 Mortality: The Importance of HDL Function

Related references

Note: Only part of the references are listed.
Article Chemistry, Multidisciplinary

Towards a Precise NMR Quantification of Acute Phase Inflammation Proteins from Human Serum

Alvaro Mallagaray et al.

Summary: Nuclear Magnetic Resonance (NMR) spectra of human serum and plasma can identify the signals GlycA and GlycB, which come from the acetyl groups of glycoprotein glycans and serve as markers for inflammatory processes. This study provides a detailed assignment of glycoprotein glycan NMR signals in human serum, revealing that GlycA and GlycB signals correspond to specific N-glycans. The concentrations of acute phase glycoproteins, determined conventionally, show a strong correlation with distinctive features in the NMR spectra, enabling the simultaneous quantification of multiple acute phase inflammation proteins.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2023)

Article Biochemistry & Molecular Biology

The role of high cholesterol in SARS-CoV-2 infectivity

Hao Wang et al.

Summary: Increasing the localization of ACE2 near endocytic lipids enhances viral infectivity, shedding light on the selective severity of COVID-19 in aged and diseased populations.

JOURNAL OF BIOLOGICAL CHEMISTRY (2023)

Article Biochemistry & Molecular Biology

Macrophage ACE2 is necessary for SARS-CoV-2 replication and subsequent cytokine responses that restrict continued virion release

Larisa I. Labzin et al.

Summary: Macrophages are important cells in the development of COVID-19, and ACE2 receptors are only present on a subset of macrophages at infection sites. Research shows that ACE2-deficient macrophages do not replicate the virus or induce inflammatory cytokine expression, while ACE2-overexpressing macrophages can replicate and release the virus.

SCIENCE SIGNALING (2023)

Review Pharmacology & Pharmacy

A Current Update on the Role of HDL-Based Nanomedicine in Targeting Macrophages in Cardiovascular Disease

Alankrita Rani et al.

Summary: High-density lipoproteins (HDL) are complex nanoparticles involved in important metabolic and vascular functions. Dysregulation of HDL can lead to inflammatory remodeling and dysfunction. Monocytes and macrophages play a critical role in vascular inflammation. HDL-based nanotherapeutics show potential in treating vascular diseases by targeting these cells.

PHARMACEUTICS (2023)

Article Peripheral Vascular Disease

Low HDL-c levels at admission are associated with greater severity and worse clinical outcomes in patients with COVID-19 disease

Sandra Parra et al.

Summary: This study found that the lipid profile of COVID-19 patients at admission can serve as a prognostic biomarker, with hypolipidemia including HDL levels being associated with a higher risk of death and worse clinical manifestations.

ATHEROSCLEROSIS PLUS (2023)

Article Chemistry, Analytical

J-Edited DIffusional Proton Nuclear Magnetic Resonance Spectroscopic Measurement of Glycoprotein and Supramolecular Phospholipid Biomarkers of Inflammation in Human Serum

Philipp Nitschke et al.

Summary: This study presents a J-Edited Diffusional (JEDI) proton NMR spectroscopic approach that selectively enhances signals from inflammatory markers in blood serum. The results show that JEDI is an improved method for selectively investigating inflammatory signals in serum and may have widespread diagnostic applicability to disease states associated with systemic inflammation.

ANALYTICAL CHEMISTRY (2022)

Article Peripheral Vascular Disease

Relationship Between Blood Lipid Levels and Mortality in Hospitalized COVID-19 Patients

Sidar S. Aydin et al.

Summary: This study aimed to investigate the relationship between lipid levels and mortality in COVID-19 patients. It found that low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) levels were significantly associated with COVID-19-related death risk. Low and high LDL-C, low HDL-C, and high TG levels were negatively correlated with mortality in COVID-19 patients.

ANGIOLOGY (2022)

Article Genetics & Heredity

Disturbed lipid and amino acid metabolisms in COVID-19 patients

Mojgan Masoodi et al.

Summary: This study found significant differences in plasma metabolic signatures between COVID-19 patients and control group, primarily in lipid and amino acid metabolism. Protein systems biology analysis revealed that COVID-19 mainly impacted sphingolipid, tryptophan, tyrosine, glutamine, arginine, and arachidonic acid metabolism pathways. Additionally, decreased levels of GABA could serve as a potential biomarker and therapeutic target for COVID-19 patients.

JOURNAL OF MOLECULAR MEDICINE-JMM (2022)

Article Cardiac & Cardiovascular Systems

Glycoprotein Acetyls: A Novel Inflammatory Biomarker of Early Cardiovascular Risk in the Young

Scott T. Chiesa et al.

Summary: GlycA is associated with the development of cardiovascular disease risk and predicts the risk of hypertension and metabolic syndrome. In contrast, CRP has little correlation.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2022)

Article Medicine, General & Internal

Triglyceride/High-Density Lipoprotein Cholesterol Ratio is Associated with the Mortality of COVID-19: A Retrospective Study in China

Fei Peng et al.

Summary: The study suggests that the TG/HDL-c ratio might be a predictive marker for mortality in COVID-19 patients. Compared to survivors, non-survivors had higher levels of white blood cells, neutrophils, C-reactive proteins, and TG/HDL-c ratio. The TG/HDL-c ratio was positively correlated with white blood cells, neutrophils, and C-reactive proteins, and patients with high TG/HDL-c ratio had worse survival.

INTERNATIONAL JOURNAL OF GENERAL MEDICINE (2022)

Article Chemistry, Analytical

Exploration of Human Serum Lipoprotein Supramolecular Phospholipids Using Statistical Heterospectroscopy in n-Dimensions (SHY-n): Identification of Potential Cardiovascular Risk Biomarkers Related to SARS-CoV-2 Infection

Reika Masuda et al.

Summary: SARS-CoV-2 infection leads to a decrease in lipoprotein-bound serum phospholipids, resulting in supra-molecular phospholipid composite (SPC) signals detected in diffusion and relaxation edited H-1 NMR spectra. This study utilized Statistical HeterospectroscoY in n-dimensions (SHYn) approach to identify the major phospholipid components contributing to the SPC signals and correlated them with lipoprotein and lipid measurements. The SPC3/SPC2 ratio was strongly correlated with the apolipoprotein B100/A1 ratio, indicating the potential of serum SPC measurement as a metric of cardiovascular risk based on a single NMR experiment.

ANALYTICAL CHEMISTRY (2022)

Article Endocrinology & Metabolism

Machine learning and semi-targeted lipidomics identify distinct serum lipid signatures in hospitalized COVID-19-positive and COVID-19-negative patients

Helena Castane et al.

Summary: The study found that COVID-19 infection shares many lipid alterations with other infectious/inflammatory diseases, but there are also some differences. The most notable alterations were observed in oxylipins in COVID-19 patients, while bile acids and glycerophospholipids best distinguished between COVID-19-positive and COVID-19-negative patients.

METABOLISM-CLINICAL AND EXPERIMENTAL (2022)

Article Microbiology

Altered Lipid Profile in COVID-19 Patients and Metabolic Reprogramming

Tie Zhao et al.

Summary: COVID-19 patients may exhibit dyslipidemia, with lower levels of TC and HDL-C compared to healthy individuals. Differential proteins associated with COVID-19 are involved in lipid pathways, and SARS-CoV-2 infection may induce metabolic reprogramming.

FRONTIERS IN MICROBIOLOGY (2022)

Article Biochemistry & Molecular Biology

First Recombinant High-Density Lipoprotein Particles Administration in a Severe ICU COVID-19 Patient, a Multi-Omics Exploratory Investigation

Sebastien Tanaka et al.

Summary: This study investigated the use of recombinant HDL particles in a severe COVID-19 patient. The results showed that recombinant HDL increased ApoA1 abundance, increased the proportion of large HDL particles, and decreased the abundance of inflammatory proteins. Levels of inflammatory markers and cytokines also decreased during recombinant HDL infusion. Therefore, recombinant HDL infusion may be a potential therapeutic strategy for COVID-19 patients.

BIOMEDICINES (2022)

Review Cardiac & Cardiovascular Systems

Association of Lipid Levels With COVID-19 Infection, Disease Severity and Mortality: A Systematic Review and Meta-Analysis

Vignesh Chidambaram et al.

Summary: Low lipid levels are associated with disease severity and mortality in COVID-19 patients.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)

Review Infectious Diseases

The tryptophan catabolite or kynurenine pathway in COVID-19 and critical COVID-19: a systematic review and meta-analysis

Abbas F. Almulla et al.

Summary: This study found increased activity of the IDO enzyme in COVID-19 and severe/critical patients, suggesting that the TRYCAT pathway is involved in the pathophysiology and progression of COVID-19.

BMC INFECTIOUS DISEASES (2022)

Article Biochemistry & Molecular Biology

Quantitative Serum NMR Spectroscopy Stratifies COVID-19 Patients and Sheds Light on Interfaces of Host Metabolism and the Immune Response with Cytokines and Clinical Parameters

Titus Roessler et al.

Summary: By analyzing the clinical samples of a large outpatient cohort using nuclear magnetic resonance spectroscopy, we characterized COVID-19 and found markers of oxidative stress and severe dysregulation of energy metabolism. NMR markers showed predictive power comparable to laboratory parameters, and we demonstrated the interaction between metabolism and the immune system.

METABOLITES (2022)

Article Medicine, General & Internal

HDL cholesterol levels and susceptibility to COVID-19

Vignesh Chidambaram et al.

Summary: This study found that individuals with higher antecedent serum high-density lipoprotein cholesterol (HDL-C) levels had a lower risk of SARS-CoV-2 infection. However, low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglyceride (TG) levels were not independently associated with infection risk. In COVID-19 patients, serum HDL-C and LDL-C levels transiently decreased at the time of infection.

EBIOMEDICINE (2022)

Article Virology

High-density lipoproteins may play a crucial role in COVID-19

Minu Nain et al.

Summary: This study found that patients with COVID-19 have significantly low levels of high-density lipoprotein (HDL), while total cholesterol (TC) and low-density lipoproteins (LDL) levels are normal. This suggests that HDL may play an important role in COVID-19 infection and outcomes, and further research on this relationship is needed.

VIROLOGY JOURNAL (2022)

Article Pharmacology & Pharmacy

Using an untargeted metabolomics approach to analyze serum metabolites in COVID-19 patients with nucleic acid turning negative

Wenyu Chen et al.

Summary: This study utilized untargeted metabolomics analysis to characterize the metabolic alterations in COVID-19 patients with nucleic acid turning negative. The results showed dysregulation in amino acid metabolism and lipid metabolism, highlighting the need for specific post-treatment care to aid the recovery of COVID-19 patients.

FRONTIERS IN PHARMACOLOGY (2022)

Article Pharmacology & Pharmacy

Apolipoprotein-A-I for severe COVID-19-induced hyperinflammatory states: A prospective case study

Stanislas Faguer et al.

Summary: Viral infections can cause cytokine storms and multiorgan failure in individuals with immunosuppression or specific genetic background. This study examined the use of an ApoA-I-containing HDL mimetic in four severe COVID-19 patients with cytokine storms. The treatment resulted in early clinical improvement in three patients and provides initial safety and proof-of-concept data for further evaluation.

FRONTIERS IN PHARMACOLOGY (2022)

Article Biochemistry & Molecular Biology

Low HDL Cholesterol Efflux Capacity Indicates a Fatal Course of COVID-19

Julia T. Stadler et al.

Summary: This study evaluates the impact of COVID-19 infection on HDL function and metabolism, and finds that low HDL cholesterol efflux capacity is associated with increased mortality risk in COVID-19 patients, independent of HDL-cholesterol levels.

ANTIOXIDANTS (2022)

Article Immunology

Metabolic Reprogramming in SARS-CoV-2 Infection Impacts the Outcome of COVID-19 Patients

Laura E. Martinez-Gomez et al.

Summary: This study aimed to characterize the profile of amino acids and acylcarnitines in COVID-19 patients. The findings suggest that metabolic imbalance may affect disease progression in COVID-19 patients, and phenylalanine may serve as a potential metabolic biomarker for evaluating disease severity.

FRONTIERS IN IMMUNOLOGY (2022)

Article Multidisciplinary Sciences

ACE2 protein expression in lung tissues of severe COVID-19 infection

Atish Gheware et al.

Summary: This study found significantly higher ACE2 protein expression in the lung tissues of deceased COVID-19 patients, which correlated with pathological changes and disease severity.

SCIENTIFIC REPORTS (2022)

Review Medicine, Research & Experimental

COVID-19 metabolism: Mechanisms and therapeutic targets

Tianshi Wang et al.

Summary: SARS-CoV-2 infection causes dysregulation of host cell metabolism and interactions between viral proteins and metabolic regulators. Cholesterol, lipid, and glucose metabolism play important roles in viral lifecycle. Understanding COVID-19 metabolism could lead to new therapeutic targets and accelerate drug repurposing or screening.

MEDCOMM (2022)

Review Medicine, General & Internal

Cytokine Storm in COVID-19: Immunopathogenesis and Therapy

Christian Zanza et al.

Summary: Cytokine storm is an excessive inflammatory state caused by an immune system dysregulation, which can lead to multi-organ failure and death. Initially described in graft-versus-host disease, it has been extended to other diseases such as COVID-19. Various drugs have been tested to mitigate cytokine storm, with some showing effectiveness in reducing mortality, especially in critically ill patients.

MEDICINA-LITHUANIA (2022)

Review Virology

The cytokine storm and COVID-19

Biying Hu et al.

Summary: COVID-19, caused by SARS-CoV-2, has become a global pandemic since its emergence in Wuhan, China, in December 2019, posing a serious threat to public health. Close contact and respiratory droplets are the main modes of transmission. The cytokine storm is closely associated with disease severity and mortality, emphasizing the importance of studying and treating the cytokine storm in COVID-19.

JOURNAL OF MEDICAL VIROLOGY (2021)

Review Nutrition & Dietetics

Lipid profile as an indicator of COVID-19 severity: A systematic review and meta-analysis

Roshan Kumar Mahat et al.

Summary: This study conducted a systematic review and meta-analysis of 19 studies to evaluate the association of lipid profile with severity and mortality in COVID-19 patients. The findings suggest that levels of total cholesterol, HDL-C, and LDL-C are significantly decreased in severe cases, and HDL-C and LDL-C are lower in non-survivors compared to survivors. The lipid profile may be used for assessing the severity and prognosis of COVID-19.

CLINICAL NUTRITION ESPEN (2021)

Article Immunology

Phenylalanine and COVID-19: Tracking disease severity markers

Rafael Luis Luporini et al.

Summary: The study found that serum phenylalanine levels are positively correlated with disease severity in COVID-19 patients, independent of inflammatory cytokines. Patients with mild disease have lower serum phenylalanine levels in the early stages of the disease.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

Review Biochemistry & Molecular Biology

Metabolic Reprogramming in COVID-19

Tao Shen et al.

Summary: Plenty of research has shown significant changes in metabolism due to COVID-19, leading to the perspective that COVID-19 is a metabolic disease. Reprogramming of amino acid, glucose, cholesterol and fatty acid is a distinctive characteristic of COVID-19 infection, offering new insights into COVID-19 pathophysiology. This metabolic reprogramming provides opportunities for developing novel biomarkers and therapeutic agents for effective adjuvant therapies against COVID-19 infection.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Multidisciplinary Sciences

Altered high-density lipoprotein composition and functions during severe COVID-19

Floran Begue et al.

Summary: The study showed significant changes in HDL proteome and decreased functionality in severe COVID-19 patients.

SCIENTIFIC REPORTS (2021)

Article Pharmacology & Pharmacy

HDL proteome remodeling associates with COVID-19 severity

Douglas Ricardo Souza Junior et al.

Summary: The study found significant changes in the HDL proteome of COVID-19 patients, which were associated with disease severity. Certain specific HDL proteins were related to worsening condition in hospitalized patients, while others may be associated with the survival rate of COVID-19 patients.

JOURNAL OF CLINICAL LIPIDOLOGY (2021)

Article Chemistry, Analytical

Diffusion and Relaxation Edited Proton NMR Spectroscopy of Plasma Reveals a High-Fidelity Supramolecular Biomarker Signature of SARS-CoV-2 Infection

Samantha Lodge et al.

Summary: Nuclear magnetic resonance spectroscopy-based plasma phenotyping using DIRE technique successfully revealed diagnostic molecular signatures of SARS-CoV-2 infection in plasma. Comparison of plasma samples from different groups showed differences in concentrations of specific metabolites in SARS-CoV-2 positive patients, suggesting potential molecular markers for COVID-19 diagnosis.

ANALYTICAL CHEMISTRY (2021)

Article Biochemistry & Molecular Biology

Association of serum HDL-cholesterol and apolipoprotein A1 levels with risk of severe SARS-CoV-2 infection

James R. Hilser et al.

Summary: Individuals with features of metabolic syndrome are more susceptible to severe COVID-19 caused by SARS-CoV-2. Higher levels of serum HDL-cholesterol and apolipoprotein A1 may reduce the risk of SARS-CoV-2 infection, but genetically elevated HDL-cholesterol levels are not associated with SARS-CoV-2 infection.

JOURNAL OF LIPID RESEARCH (2021)

Article Multidisciplinary Sciences

Link between serum lipid signature and prognostic factors in COVID-19 patients

Michele Dei Cas et al.

Summary: The serum lipidome of COVID-19 patients shows significant and unique dyslipidemia related to factors such as inflammation, hypoxia, coagulation state, kidney function, and age, indicating reduced defense against oxidative stress. A particular lipidome signature was identified in patients with different outcomes after 7 days, with an increase in specific lipid species like ceramides and sulfatides, potentially serving as biomarkers for disease progression and severity.

SCIENTIFIC REPORTS (2021)

Article Immunology

Altered Lipid Profile Is a Risk Factor for the Poor Progression of COVID-19: From Two Retrospective Cohorts

Hui Jin et al.

Summary: The study found that baseline dyslipidemia may be associated with an increased risk of re-positive or in-hospital death in COVID-19 patients, and lipid levels also change throughout the course of the disease. Additionally, there is a relationship between inflammatory biomarkers, organ function indicators, and lipid levels in patients.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

Article Biochemistry & Molecular Biology

Increased Kynurenine Indicates a Fatal Course of COVID-19

Harald Mangge et al.

Summary: Kynurenine is a promising blood biomarker for predicting mortality risk in severe COVID-19 cases, with KYN levels at the time of SARS-CoV-2 diagnosis serving as an early indicator of poor outcomes. Age, KYN, ferritin, and other markers were found to significantly impact survival time, underscoring the potential of Kynurenine as a prognostic tool in COVID-19 management.

ANTIOXIDANTS (2021)

Article Biochemistry & Molecular Biology

Metabolic and Lipidomic Markers Differentiate COVID-19 From Non-Hospitalized and Other Intensive Care Patients

Franziska Schmelter et al.

Summary: The metabolic serum profile of COVID-19 patients differs significantly from healthy controls and patients with cardiogenic shock. However, individuals with anti-SARS-CoV-2 antibodies but without severe disease do not show significant metabolic disturbances. This suggests that dyslipidemia may be a confounding risk factor for COVID-19 and could be used for patient stratification.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

Review Rheumatology

Systemic and organ-specific immune-related manifestations of COVID-19

Manuel Ramos-Casals et al.

Summary: Immune-related disorders in patients with COVID-19 present with diverse manifestations mimicking various inflammatory and autoimmune diseases, with clinical phenotype influenced by factors like age, sex, and ethnicity. The severity of symptoms varies greatly, from benign to life-threatening, and the pathogenesis and optimal therapy for these manifestations require further research.

NATURE REVIEWS RHEUMATOLOGY (2021)

Article Multidisciplinary Sciences

Low HDL and high triglycerides predict COVID-19 severity

Lluis Masana et al.

Summary: The presence of atherogenic dyslipidaemia during COVID-19 infection is strongly associated with a worse prognosis. Low HDL cholesterol and high triglyceride concentrations, either before or during hospitalization, are strong predictors of a severe course of the disease. Lipid profiles can be considered as sensitive markers of inflammation in patients with COVID-19 and should be measured.

SCIENTIFIC REPORTS (2021)

Review Biochemical Research Methods

Statistical analysis in metabolic phenotyping

Benjamin J. Blaise et al.

Summary: Metabolic phenotyping plays a crucial role in translational biomedical research, utilizing advanced analytical technologies such as MS and NMR spectroscopy. This paper proposes an efficient protocol for statistical analysis of metabolic data generated by these methods, offering solutions for various steps in the data analytics workflow. The protocol describes a minimal set of analyses needed to rigorously investigate typical datasets encountered in metabolic phenotyping.

NATURE PROTOCOLS (2021)

Article Biochemistry & Molecular Biology

MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights

Zhiqiang Pang et al.

Summary: MetaboAnalyst version 5.0 has been introduced to facilitate comprehensive metabolomics data analysis and interpretation, with the aim of narrowing the gap from raw data to functional insights. Three new modules have been developed to assist in this goal, along with various other new functions and improvements in interface, graphics, and codebase. Users can now easily switch between compatible modules for a streamlined data analysis experience.

NUCLEIC ACIDS RESEARCH (2021)

Review Virology

Association of dyslipidemia with the severity and mortality of coronavirus disease 2019 (COVID-19): a meta-analysis

Yanli Liu et al.

Summary: This study analyzed the potential association of dyslipidemia with the severity and mortality of COVID-19. The results showed that dyslipidemia is associated with increased severity and mortality of COVID-19. It is important to monitor blood lipids and administer active treatments in COVID-19 patients with dyslipidemia to reduce the severity and mortality.

VIROLOGY JOURNAL (2021)

Article Multidisciplinary Sciences

Alterations of lipid metabolism provide serologic biomarkers for the detection of asymptomatic versus symptomatic COVID-19 patients

Alhaji H. Janneh et al.

Summary: Changes in sphingolipids are closely related to the development of COVID-19, with reduced levels of sphingosine potentially serving as a sensitive biomarker for the early identification of symptomatic and asymptomatic COVID-19 patients.

SCIENTIFIC REPORTS (2021)

Article Biochemistry & Molecular Biology

Diagnostic Potential of the Plasma Lipidome in Infectious Disease: Application to Acute SARS-CoV-2 Infection

Nicola Gray et al.

Summary: Using lipid profiling and multivariate modeling, a refined panel of discriminant features from different lipid subclasses was developed to effectively differentiate between SARS-CoV-2 infection, healthy controls, and non-SARS-CoV-2 respiratory infections. The analysis showed strong predictive power and potential for facilitating accurate diagnosis and clinical management of the virus.

METABOLITES (2021)

Article Multidisciplinary Sciences

Inferring a causal relationship between ceramide levels and COVID-19 respiratory distress

Mehran M. Khodadoust

Summary: The study suggests a causal relationship between plasma ceramide concentration and respiratory distress symptoms in COVID-19 patients, with ceramide class lipids exhibiting a significant increase in infected patients. Specific subclasses of ceramides were shown to be greatly increased in plasma samples with respiratory distress, highlighting the potential value of monitoring plasma ceramide concentration for assessing the effects of therapies on COVID-19 respiratory distress patients.

SCIENTIFIC REPORTS (2021)

Review Medicine, General & Internal

Human Serum/Plasma Glycoprotein Analysis by 1H-NMR, an Emerging Method of Inflammatory Assessment

Rocio Fuertes-Martin et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Article Biochemistry & Molecular Biology

Proteomic and Metabolomic Characterization of COVID-19 Patient Sera

Bo Shen et al.

Review Cardiac & Cardiovascular Systems

COVID-19 and Multiorgan Response

Sevim Zaim et al.

CURRENT PROBLEMS IN CARDIOLOGY (2020)

Review Biochemistry & Molecular Biology

The cytokine storm in COVID-19: An overview of the involvement of the chemokine/chemokine-receptor system

Francesca Coperchini et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2020)

Article Medicine, General & Internal

Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area

Safiya Richardson et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Review Cell Biology

COVID-19 and multiorgan failure: A narrative review on potential mechanisms

Tahmineh Mokhtari et al.

JOURNAL OF MOLECULAR HISTOLOGY (2020)

Article Biochemistry & Molecular Biology

Low high-density lipoprotein level is correlated with the severity of COVID-19 patients: an observational study

Guyi Wang et al.

LIPIDS IN HEALTH AND DISEASE (2020)

Article Multidisciplinary Sciences

SARS-CoV-2 Infection Dysregulates the Metabolomic and Lipidomic Profiles of Serum

Chiara Bruzzone et al.

ISCIENCE (2020)

Article Biochemistry & Molecular Biology

Large-Scale Plasma Analysis Revealed New Mechanisms and Molecules Associated with the Host Response to SARS-CoV-2

Elettra Barberis et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Cardiac & Cardiovascular Systems

GlycA measured by NMR spectroscopy is associated with disease activity and cardiovascular disease risk in chronic inflammatory diseases

Nehal N. Mehta et al.

AMERICAN JOURNAL OF PREVENTIVE CARDIOLOGY (2020)

Review Chemistry, Multidisciplinary

High-Throughput Metabolomics by 1D NMR

Alessia Vignoli et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Review Medicine, Research & Experimental

GlycA, a novel biomarker of systemic inflammation and cardiovascular disease risk

Margery A. Connelly et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2017)

Review Biochemistry & Molecular Biology

Effect of inflammation on HDL structure and function

Kenneth R. Feingold et al.

CURRENT OPINION IN LIPIDOLOGY (2016)

Review Pharmacology & Pharmacy

Inflammation alters HDL composition and function: Implications for HDL-raising therapies

Gunther Marsche et al.

PHARMACOLOGY & THERAPEUTICS (2013)