☆ 4.7 Article

Unveiling the complexation mechanism of phloretin with Sulfobutylether-fl-cyclodextrin (Captisol®) and its impact on anticancer activity

JOURNAL OF MOLECULAR LIQUIDS (2023)

Related references

Note: Only part of the references are listed.

Article Chemistry, Physical

Deciphering the interactions of genistein with β-cyclodextrin derivatives through experimental and microsecond timescale umbrella sampling simulations

Nabab Khan et al.

Summary: This study investigates the molecular mechanism of inclusion of Genistein (GEN) inside cyclodextrins (CDs), which improves its solubility and stability. Experimental methods and molecular dynamics simulations were used to characterize the inclusion complexes (ICs) and demonstrate their formation.

JOURNAL OF MOLECULAR LIQUIDS (2023)

Add to Collection

Article Biochemistry & Molecular Biology

Characterization of Thymoquinone-Sulfobutylether-β-Cyclodextrin Inclusion Complex for Anticancer Applications

Eltayeb E. M. Eid et al.

Summary: This study aimed to improve the solubility of TQ by forming inclusion complexes with SBE-beta-CD and found that these complexes exhibited enhanced antiproliferative activity against various cancer cell lines. However, further research is needed to fully understand the mechanisms and potential side effects of using SBE-beta-CD as a drug delivery system for TQ.

MOLECULES (2023)

Add to Collection

Article Chemistry, Applied

Preparation and characterization of inclusion complex of Myristica fragrans Houtt. (nutmeg) essential oil with 2-hydroxypropyl-β-cyclodextrin

Xiaohui Xi et al.

Summary: This study prepared the inclusion complex (IC) of nutmeg essential oil (NEO) with 2-hydroxypropyl ss-cyclodextrin (HP-ss-CD) by the coprecipitation method, overcoming the poor stability and low aqueous solubility of NEO in food. The optimal conditions were an inclusion temperature of 36 degrees C, time of 247 min, stirring speed of 520 r/min, and wall-core ratio of 12:1, resulting in a recovery of 80.63%. The formation of IC was confirmed by various techniques, and it was found that encapsulation improved the thermal stability, antioxidant, and nitrite scavenging activities of NEO. Moreover, the release of NEO from IC can be controlled by regulating the temperature and relative humidity. Overall, NEO/HP-ss-CD IC has great potential for application in the food industry.

FOOD CHEMISTRY (2023)

Add to Collection

Article Pharmacology & Pharmacy

Formulation of ternary genistein β-cyclodextrin inclusion complex: In vitro characterization and cytotoxicity assessment using breast cancer cell line

Ameeduzzafar Zafar et al.

Summary: This study demonstrates that the use of beta-cyclodextrin and TPGS as complexing agents can improve the solubility and in vitro activity of Genistein, enhancing its antioxidant and cell viability activities. The complexation process transforms crystalline Genistein into an amorphous state, and the formed inclusion complex exhibits stronger activity against MCF7 cells.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2022)

Add to Collection

Article Agriculture, Multidisciplinary

Encapsulating quercetin in cyclodextrin metal-organic frameworks improved its solubility and bioavailability

Zhenjiong Wang et al.

Summary: Quercetin-loaded gamma-cyclodextrin metal-organic frameworks (Que-CD-MOFs) have significantly enhanced solubility and free radical scavenging ability. Que-CD-MOFs exhibit reduced cytotoxicity to HK-2 cells and maintained inhibition on HT-29 tumor cells, with a preferential location of Que molecules inside the cavities of gamma-cyclodextrin pairs in gamma-CD-MOFs.

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2022)

Add to Collection

Article Chemistry, Physical

Inclusion complexation of emodin with various β-cyclodextrin derivatives: Preparation, characterization, molecular docking, and anticancer activity

Amy Oo et al.

Summary: Encapsulation with beta-cyclodextrin (β-CD) has been explored to enhance the solubility of emodin (ED) for pharmaceutical applications. In this study, inclusion complexation of ED with β-CD and its derivatives was performed to identify the most promising drug carrier. The ED/DM-β-CD complex showed the highest stability and water solubility, followed by ED/SBE7-β-CD and ED/HP-β-CD complexes. The SEM micrographs and DSC thermograms confirmed the inclusion complex formation, and molecular docking suggested C-form insertion as the preferred binding mode. Moreover, the inclusion complexes, especially ED/DM-β-CD, showed significantly higher anti-proliferative effects on cancer cell lines compared to ED alone.

JOURNAL OF MOLECULAR LIQUIDS (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Phloretin, as a Potent Anticancer Compound: From Chemistry to Cellular Interactions

Hardeep Singh Tuli et al.

Summary: This review article discusses the diverse therapeutic properties of phloretin, including its anticancer, antioxidant, anti-inflammatory, and antidiabetic activities. The focus is on its anticancer potential, specifically its antiproliferative, proapoptotic, antimetastatic, and antiangiogenic activities in preclinical cancer models. The article also analyzes the effects of phloretin on cellular signaling pathways and proteins, enzymes, and its co-effects with conventional anticancer drugs.

MOLECULES (2022)

Add to Collection

Review Chemistry, Applied

Cyclodextrins inclusion complex: Preparation methods, analytical techniques and food industry applications

Antonio Cid-Samamed et al.

Summary: This review discusses the chemical behavior of cyclodextrin complexes with natural ingredients, synthetic drugs, and other related compounds. It provides literature and examples demonstrating the application of cyclodextrins in improving the characteristics of food compounds. Commercial food and supplement products utilizing cyclodextrins are also mentioned to highlight their potential in biotechnological substance development and food product enhancement.

FOOD CHEMISTRY (2022)

Add to Collection

Article Cell Biology

Targeting the MITF/APAF-1 axis as salvage therapy for MAPK inhibitors in resistant melanoma

Pietro Carotenuto et al.

Summary: This study identifies the MITF/APAF-1 axis as a molecular driver of MAPK inhibitor resistance in melanoma, and quinacrine and methylbenzethonium as potent activators of apoptosis and suppressors of MITF function, demonstrating their potential as therapeutic approaches for resistant melanoma.

CELL REPORTS (2022)

Add to Collection

Article Polymer Science

Cross-Linked Poly(cyclotriphosphazene-co-phloretin) Microspheres and Their Application for Controlled Drug Delivery

Sahid Mehmood et al.

Summary: In this study, cross-linked poly(cyclotriphosphazene-co-phloretin) microspheres were successfully synthesized and characterized. The size of the microspheres depended on the HCCP:Pht mole ratio, and the microspheres exhibited good crystalline nature and thermal stability. Dynamic light scattering showed that the size of the microspheres increased with decreased HCCP:Pht mole ratio. Furthermore, the microspheres demonstrated good drug loading capability and controlled release property for the model drug camptothecin.

MACROMOLECULAR RESEARCH (2022)

Add to Collection

Article Chemistry, Physical

Preparation, characterization, and molecular modeling of sesamol/β-cyclodextrin derivatives inclusion complexes

Ping Han et al.

Summary: Sesamol, a natural organic phenolic compound, has great potential in food and chemical industries but faces challenges with instability and poor aqueous solubility. In this study, three inclusion complexes were prepared using cyclodextrins as host molecules to enhance sesamol's water-solubility, with HP-beta-CD identified as the optimal host molecule.

JOURNAL OF MOLECULAR LIQUIDS (2021)

Add to Collection

Article Chemistry, Applied

Enzymatic Synthesis of Phloretin α-Glucosides Using a Sucrose Phosphorylase Mutant and its Effect on Solubility, Antioxidant Properties and Skin Absorption

Jose L. Gonzalez-Alfonso et al.

Summary: Glycosylation of polyphenols can enhance their solubility, stability, and bioavailability. The generated phloretin glucosides showed improved solubility and moderate loss in antioxidant activity, which could be recovered upon deglycosylation. In a pig skin model, the diglucoside was mainly detected in superficial layers, indicating potential applications in dermocosmetics.

ADVANCED SYNTHESIS & CATALYSIS (2021)

Add to Collection

Article Chemistry, Physical

Ultrasonication-assisted host-guest inclusion complexes of β-cyclodextrins and 5-hydroxytryptophan: Enhancement of water solubility, thermal stability, and in vitro anticancer activity

Sonaimuthu Mohandoss et al.

Summary: This study prepared inclusion complexes of 5-HTP and β-cyclodextrins using ultrasonication method and investigated their structural characteristics, phase solubility, and anti-tumor efficacy, providing potential for the development of anticancer drugs.

JOURNAL OF MOLECULAR LIQUIDS (2021)

Add to Collection

Article Chemistry, Applied

Sulfobutylether-beta-cyclodextrin-enabled antiviral remdesivir: Characterization of electrospun- and lyophilized formulations

Lajos Szente et al.

Summary: This study reveals the non-covalent interaction between remdesivir and the solubilizing excipient in VekluryTM, leading to a significant enhancement in solubility. The use of solubilizing carbohydrate greatly improves the aqueous solubility and dissolution rate of remdesivir, enabling the preparation of stable infusion solutions for therapy. NMR spectroscopy provides insights into the nature of remdesivir-excipent interaction and indicates the presence of inclusion phenomenon and electrostatic attraction in aqueous solution.

CARBOHYDRATE POLYMERS (2021)

Add to Collection

Article Food Science & Technology

Enhanced oral bioavailability and bioefficacy of phloretin using mixed polymeric modified self-nanoemulsions

Yiling Wang et al.

FOOD SCIENCE & NUTRITION (2020)

Add to Collection

Article Chemistry, Applied

A deep insight into mechanism for inclusion of 2R,3R-dihydromyricetin with cyclodextrins and the effect of complexation on antioxidant and lipid-lowering activities

Yanping Wu et al.

FOOD HYDROCOLLOIDS (2020)

Add to Collection

Article Pharmacology & Pharmacy

Sulfobutylether-β-cyclodextrin

Valentino J. Stella et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

Add to Collection

Article Chemistry, Multidisciplinary

Physicochemical Characterization, Molecular Docking, and In Vitro Dissolution of Glimepiride-Captisol Inclusion Complexes

Arpita Pal et al.

ACS OMEGA (2020)

Add to Collection

Article Biochemistry & Molecular Biology

The investigation of binary and ternary sulfobutylether-β-cyclodextrin inclusion complexes with asiaticoside in solution and in solid state

Hay ManSaung Hnin Soe et al.

CARBOHYDRATE RESEARCH (2020)

Add to Collection

Article Chemistry, Multidisciplinary

Preparation and characterization of phloretin by complexation with cyclodextrins

Xiaona Hu et al.

NEW JOURNAL OF CHEMISTRY (2020)

Add to Collection

Article Chemistry, Multidisciplinary

Comparative effects of β-cyclodextrin, HP-β-cyclodextrin and SBE7-β-cyclodextrin on the solubility and dissolution of docetaxel via inclusion complexation

Hadia Sadaquat et al.

JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Phloretin loaded chitosan nanoparticles augments the pH-dependent mitochondrial-mediated intrinsic apoptosis in human oral cancer cells

Arokia Vijaya Anand Mariadoss et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

Add to Collection

Article Chemistry, Multidisciplinary

Preparation and characterization of cyanazine-hydroxypropyl-beta-cyclodextrin inclusion complex

Shuang Gao et al.

RSC ADVANCES (2019)

Add to Collection

Article Biochemistry & Molecular Biology

2′,3,4-trihydroxychalcone, phloretin and calomelanone from Stevia lucida. The first chalcones reported in Stevia Genus

Pablo A. Chacon Morales et al.

BIOCHEMICAL SYSTEMATICS AND ECOLOGY (2018)

Add to Collection

Article Chemistry, Medicinal

Cyclodextrin complexes: Perspective from drug delivery and formulation

Shery Jacob et al.

DRUG DEVELOPMENT RESEARCH (2018)

Add to Collection

Article Pharmacology & Pharmacy

Effect of alkylaminophenols on growth inhibition and apoptosis of bone cancer cells

Phuong Doan et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2017)

Add to Collection

Article Chemistry, Physical

Phloretin-loaded fast dissolving nanofibers for the locoregional therapy of oral squamous cell carcinoma

Suyeong Nam et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2017)

Add to Collection

Article Chemistry, Physical

Molecular model and in vitro antioxidant activity of a water-soluble and stable phloretin/hydroxypropyl-β-cyclodextrin inclusion complex

Yongqin Wei et al.

JOURNAL OF MOLECULAR LIQUIDS (2017)

Add to Collection

Article Chemistry, Physical

Inclusion complex of nateglinide with sulfobutyl ether β-cyclodextrin: Preparation, characterization and water solubility

Jingna Xu et al.

JOURNAL OF MOLECULAR STRUCTURE (2017)

Add to Collection

Article Chemistry, Physical

Inclusion complex of chrysin with sulfobutyl ether-β-cyclodextrin (Captisol®): Preparation, characterization, molecular modelling and in vitro anticancer activity

Abhijeet D. Kulkarni et al.

JOURNAL OF MOLECULAR STRUCTURE (2017)

Add to Collection

Article Plant Sciences

Health effects of phloretin: from chemistry to medicine

Sahar Behzad et al.

PHYTOCHEMISTRY REVIEWS (2017)

Add to Collection

Review Biochemistry & Molecular Biology

Activation of apoptosis signalling pathways by reactive oxygen species

Maureen Redza-Dutordoir et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2016)

Add to Collection

Article Chemistry, Physical

Host-guest inclusion systems of daidzein with 2-hydroxypropy1-β-cyclodextrin (HP-β-CD) and sulfobutyl ether-β-cyclodextrin (SBE-β-CD): Preparation, binding behaviors and water solubility

Yinghui Deng et al.

JOURNAL OF MOLECULAR STRUCTURE (2016)

Add to Collection

Article Chemistry, Applied

Inclusion complex of erlotinib with sulfobutyl ether-β-cyclodextrin: Preparation, characterization, in silico, in vitro and in vivo evaluation

Naresh Devasari et al.

CARBOHYDRATE POLYMERS (2015)

Add to Collection

Article Pharmacology & Pharmacy

Preparation and Pharmacokinetic Study of Aprepitant-Sulfobutyl Ether-β-Cyclodextrin Complex

Lili Ren et al.

AAPS PHARMSCITECH (2014)

Add to Collection

Article Biophysics

A characterization study of resveratrol/sulfobutyl ether-β-cyclodextrin inclusion complex and in vitro anticancer activity

Valentina Venuti et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2014)

Add to Collection

Article Biochemistry & Molecular Biology

Synthesis, Crystal Structure, and Biological Evaluation of a Series of Phloretin Derivatives

Li Wang et al.

MOLECULES (2014)

Add to Collection

Article Pharmacology & Pharmacy

Baicalein and hydroxypropyl-γ-cyclodextrin complex in poloxamer thermal sensitive hydrogel for vaginal administration

Qiuna Zhou et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2013)

Add to Collection

Article Multidisciplinary Sciences

Potential use of Folate-appended Methyl-β-Cyclodextrin as an Anticancer Agent

Risako Onodera et al.

SCIENTIFIC REPORTS (2013)

Add to Collection

Article Pharmacology & Pharmacy

Sulfobutyl Ether7 β-Cyclodextrin (SBE7 β-CD) Carbamazepine Complex: Preparation, Characterization, Molecular Modeling, and Evaluation of In Vivo Anti-epileptic Activity

Ankitkumar S. Jain et al.

AAPS PHARMSCITECH (2011)

Add to Collection

Review Biochemical Research Methods

Cytometric Assessment of Mitochondria Using Fluorescent Probes

Cecile Cottet-Rousselle et al.

CYTOMETRY PART A (2011)

Add to Collection

Review Biochemistry & Molecular Biology

Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases

Andreas Strasser et al.

EMBO JOURNAL (2011)

Add to Collection

Review Biochemistry & Molecular Biology

Reactive oxygen species in cancer

Geou-Yarh Liou et al.

FREE RADICAL RESEARCH (2010)

Add to Collection

Article Biochemistry & Molecular Biology

Host-guest complexation of oxicam NSAIDs with β-cyclodextrin

R Banerjee et al.

BIOPOLYMERS (2004)

Add to Collection

© Peeref 2019-2024. All rights reserved.