Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 111, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jff.2023.105887
Keywords
Nut oil; Caco-2 cell; Intestinal barrier; Tight junction protein
Categories
Ask authors/readers for more resources
This study confirms the protective effect of four nut oils on the damaged intestinal epithelial barrier. Nut oils improve barrier function, inhibit inflammatory response and cytokine production, and enhance the expression and distribution of tight junction proteins in damaged cells.
Damage to the intestinal barrier causes intestinal inflammation, which could lead to the development of gastrointestinal diseases. Nut oils contain an abundance of unsaturated fatty acids, which are responsible for most of the bioactivities of nut oils. Here, the protective effect of four nut oils on the intestinal epithelial barrier was confirmed using Caco-2 cells damaged by tumor necrosis factor-alpha/interferon-gamma treatment. Nut oils effectively increased transepithelial electronic resistance and lowered paracellular fluorescein isothiocyanate-dextran permeability in damaged Caco-2 cells. Furthermore, the nut oils inhibited the pro-inflammatory cytokine production of interleukin-6, which was induced by the inflammatory response. In particular, walnut oil effectively improved tight junction protein (occludin and zonula occludens-1) expression and distribution in damaged Caco2 cells. In conclusion, our findings suggest that nut oils are promising candidates for impaired intestinal barrier protection.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available