☆ 4.8 Article

Liquid Biopsy in Organ Damage: small extracellular vesicle chip-based assessment of polytrauma

FRONTIERS IN IMMUNOLOGY (2023)

Related references

Note: Only part of the references are listed.

Article Health Policy & Services

Hospital-based autonomous pre-clinical screening of COVID-19: An emergency triage using a vital signs recording system, Paris-Ile de France region

Albert Brizio et al.

Summary: This article discusses a unique experience of using a Telemedicine Booth as a screening process during the COVID-19 epidemic in a private hospital in France. The study found that the use of the Telemedicine Booth facilitated the flow of patients and relieved pressure on the hospital's emergency department in a safe and secure environment.

HEALTH SERVICES MANAGEMENT RESEARCH (2023)

Add to Collection

Article Multidisciplinary Sciences

Multiplexed analysis of EV reveals specific biomarker composition with diagnostic impact

Joshua D. Spitzberg et al.

Summary: This study developed a technique called MASEV for multiplexed analysis of EVs, which allows the interrogation of thousands of individual EVs using multi-channel fluorescence staining. The findings reveal the presence of multiple biomarkers in single vesicles and the potential loss of rare EV subtypes through affinity purification. These findings demonstrate the importance of MASEV in uncovering the heterogeneity and biology of EVs and improving diagnostic specificity.

NATURE COMMUNICATIONS (2023)

Add to Collection

Article Immunology

Release of exosomes in polytraumatized patients: The injury pattern is reflected by the surface epitopes

Birte Weber et al.

Summary: The aim of this study was to investigate whether the surface epitopes of plasma-exosomes can reflect the injury pattern in polytrauma. The results showed no increase in the total amount of plasma-exosomes in polytrauma patients, but changes in the exosomal surface epitopes were observed. In conclusion, the injury pattern of polytrauma patients may be reflected by the cellular origin and surface structure of plasma-released exosomes.

FRONTIERS IN IMMUNOLOGY (2023)

Add to Collection

Editorial Material Critical Care Medicine

Crisis Triage in the Era of COVID-19: Old Tools, New Approaches, and Unanswered Questions

Gavin H. Harris et al.

CRITICAL CARE MEDICINE (2023)

Add to Collection

Article Immunology

CD44+and CD31+extracellular vesicles (EVs) are significantly reduced in polytraumatized patients with hemorrhagic shock - evaluation of their diagnostic and prognostic potential

Birte Weber et al.

Summary: The aim of this study was to analyze whether the surface epitopes of plasma extracellular vesicles (EVs) could reflect hemorrhagic shock (HS) in polytraumatized patients, and whether cell-specific EV subpopulations could be useful diagnostic tools. The results showed a significant reduction of the total amount of plasma EVs in polytrauma patients with HS, and CD44+ and CD31+ plasma EVs were specifically altered in patients with HS and associated with transfusion, non-survival, and the need for catecholamines.

FRONTIERS IN IMMUNOLOGY (2023)

Add to Collection

Review Oncology

The emerging roles of circRNAs in cancer and oncology

Lasse S. Kristensen et al.

Summary: Circular RNAs (circRNAs) are a novel class of primarily non-coding RNAs with increasingly recognized roles in cancer development and progression through diverse mechanisms of action. In this review, the authors summarize the current understanding of circRNA biogenesis, regulation, physiological functions and pathophysiological roles in cancer. They also discuss the clinical potential of circRNAs as biomarkers, therapeutic agents and drug targets in oncology, as well as the research controversies, technical issues, and biological knowledge gaps that need to be addressed.

NATURE REVIEWS CLINICAL ONCOLOGY (2022)

Add to Collection

Article Physiology

CD14-positive extracellular vesicles in bronchoalveolar lavage fluid as a new biomarker of acute respiratory distress syndrome

Rahul Y. Mahida et al.

Summary: Recent studies suggest that EVs play important roles in the pathogenesis of ARDS and serve as potential biomarkers for ARDS. The study found that patients with sepsis-related ARDS have more monocyte-derived BAL EVs compared to sepsis patients without ARDS. However, esophagectomy patients who later developed ARDS had lower BAL EV numbers. Esophagectomy patients who developed ARDS also had higher levels of CD31+/CD63+ and CD31+/CD81+ endothelial-derived BAL EVs. Further research is needed to determine if CD31+ BAL EVs can predict ARDS in esophagectomy patients. Additionally, CD14+/CD81+ BAL EVs were significantly higher in sepsis-related ARDS patients who died within 30 days of ICU admission.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2022)

Add to Collection

Article Cell Biology

Tetraspanins distinguish separate extracellular vesicle subpopulations in human serum and plasma - Contributions of platelet extracellular vesicles in plasma samples

Nasibeh Karimi et al.

Summary: This study reveals the presence of multiple subpopulations of extracellular vesicles (EVs) carrying different tetraspanins in both plasma and serum. The sampling methods and centrifugation protocols used for blood can impact EV analysis results.

JOURNAL OF EXTRACELLULAR VESICLES (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Detailed Characterization of Small Extracellular Vesicles from Different Cell Types Based on Tetraspanin Composition by ExoView R100 Platform

Kai Breitwieser et al.

Summary: Small extracellular vesicles (sEV) show great potential as biomarkers, drug carriers, and therapeutics. However, limited phenotypic characterization of sEV at the single vesicle level has resulted in sparse knowledge of cell type-specific sEV signatures. With the introduction of next-generation sEV analysis devices, such as the ExoView R100 platform, single sEV analyses are now possible, leading to a better understanding of the complexity and heterogeneity of sEV. The study demonstrates that tetraspanin composition in sEV varies among different cell types and can be influenced by cell culture conditions.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection

Article Immunology

Simultaneous C5 and CD14 inhibition limits inflammation and organ dysfunction in pig polytrauma

Ludmila Lupu et al.

Summary: In this study, the combined inhibition therapy of complement factor C5 and TLR co-receptor CD14 was used to reduce thrombo-inflammation and organ damage in a polytrauma pig model. The therapy significantly decreased the levels of terminal complement complex (TCC), CRP, and IL-6 in the blood. It also prevented platelet consumption and TAT formation, and reduced the requirements for norepinephrine. Moreover, the therapy limited organ damage and reduced the levels of blood lipase, LDH, AST, and NGAL.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection

Review Medicine, Research & Experimental

Extracellular Vesicles and Circulating Tumour Cells-complementary liquid biopsies or standalone concepts

Artur Slomka et al.

Summary: Liquid biopsies, as biomarkers in cancer diagnosis, have great potential but also limitations. This review focuses on comparing extracellular vesicles (EVs) and circulating tumor cells (CTCs) and discussing their similarities in characterization and quantification. While it is not concluded which is better between CTCs and EVs, the review provides reasons to intensify research on both.

THERANOSTICS (2022)

Add to Collection

Article Oncology

Liquid biopsy enters the clinic - implementation issues and future challenges

Michail Ignatiadis et al.

Summary: The approval of liquid biopsy assays for detecting genetic alterations in plasma cell-free DNA has marked a tipping point for the clinical use of this technology, especially in patients with advanced-stage cancer. The next frontier is likely to be the systemic treatment of patients with 'ctDNA relapse' and other potential future applications include cancer screening and diagnosis.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

Add to Collection

Article Medicine, General & Internal

Severe Traumatic Injury Induces Phenotypic and Functional Changes of Neutrophils and Monocytes

Andrea Janicova et al.

Summary: Severe traumatic injury can lead to immune response imbalance and the development of complications. Neutrophils and monocytes show phenotypic shifts post-injury, with certain subsets displaying increased functional abnormalities that may weaken antimicrobial functions.

JOURNAL OF CLINICAL MEDICINE (2021)

Add to Collection

Review Multidisciplinary Sciences

The biology, function, and biomedical applications of exosomes

Raghu Kalluri et al.

SCIENCE (2020)

Add to Collection

Article Immunology

Trauma Severity and Its Impact on Local Inflammation in Extremity Injury-Insights From a Combined Trauma Model in Pigs

Klemens Horst et al.

FRONTIERS IN IMMUNOLOGY (2020)

Add to Collection

Article Gastroenterology & Hepatology

Synergistic effects of extracellular vesicle phenotyping and AFP in hepatobiliary cancer differentiation

Sabine K. Urban et al.

LIVER INTERNATIONAL (2020)

Add to Collection

Article Hematology

Platelet-derived extracellular vesicles released after trauma promote hemostasis and contribute to DVT in mice

Mitchell R. Dyer et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2019)

Add to Collection

Article Critical Care Medicine

Undertriaged trauma patients: Who are we missing?

Morgan Schellenberg et al.

JOURNAL OF TRAUMA AND ACUTE CARE SURGERY (2019)

Add to Collection

Article Multidisciplinary Sciences

Platelet-derived-Extracellular Vesicles Promote Hemostasis and Prevent the Development of Hemorrhagic Shock

Ernesto Lopez et al.

SCIENTIFIC REPORTS (2019)

Add to Collection

Article Hematology

Human Monocyte Heterogeneity as Revealed by High-Dimensional Mass Cytometry

Anouk A. J. Hamers et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2019)

Add to Collection

Article Biology

Cell-derived extracellular vesicles can be used as a biomarker reservoir for glioblastoma tumor subtyping

Rosemary Lane et al.

COMMUNICATIONS BIOLOGY (2019)

Add to Collection

Article Emergency Medicine

Temporal phenotyping of circulating microparticles after trauma: a prospective cohort study

Matthias Froehlich et al.

SCANDINAVIAN JOURNAL OF TRAUMA RESUSCITATION & EMERGENCY MEDICINE (2018)

Add to Collection

Article Cell Biology

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Clotilde Thery et al.

JOURNAL OF EXTRACELLULAR VESICLES (2018)

Add to Collection

Article Gastroenterology & Hepatology

Cancer-associated circulating large extracellular vesicles in cholangiocarcinoma and hepatocellular carcinoma

Henrike Julich-Haertel et al.

JOURNAL OF HEPATOLOGY (2017)

Add to Collection

Article Multidisciplinary Sciences

Changes in the pattern of plasma extracellular vesicles after severe trauma

Sahithi J. Kuravi et al.

PLOS ONE (2017)

Add to Collection

Article Multidisciplinary Sciences

Characterization of blunt chest trauma in a long-term porcine model of severe multiple trauma

K. Horst et al.

SCIENTIFIC REPORTS (2016)

Add to Collection

Letter Oncology

THP-1 cells as a model for human monocytes

Herbert Bosshart et al.

ANNALS OF TRANSLATIONAL MEDICINE (2016)

Add to Collection

Review Medicine, Research & Experimental

Dynamic microvesicle release and clearance within the cardiovascular system: triggers and mechanisms

Lisa Ayers et al.

CLINICAL SCIENCE (2015)

Add to Collection

Review Cell Biology

Local Inflammation in Fracture Hematoma: Results from a Combined Trauma Model in Pigs

K. Horst et al.

MEDIATORS OF INFLAMMATION (2015)

Add to Collection

Article Multidisciplinary Sciences

Glypican-1 identifies cancer exosomes and detects early pancreatic cancer

Sonia A. Melo et al.

NATURE (2015)

Add to Collection

Review Cell Biology

Ectosomes and exosomes: shedding the confusion between extracellular vesicles

Emanuele Cocucci et al.

TRENDS IN CELL BIOLOGY (2015)

Add to Collection

Review Cell Biology

Biological properties of extracellular vesicles and their physiological functions

Maria Yanez-Mo et al.

JOURNAL OF EXTRACELLULAR VESICLES (2015)

Add to Collection

Article Medicine, General & Internal

The systemic immune response to trauma: an overview of pathophysiology and treatment

Janet M. Lord et al.

LANCET (2014)

Add to Collection

Article Critical Care Medicine

Epidemiology of severe trauma

F. Alberdi et al.

MEDICINA INTENSIVA (2014)

Add to Collection

Article Health Care Sciences & Services

The Cost Of Overtriage: More Than One-Third Of Low-Risk Injured Patients Were Taken To Major Trauma Centers

Craig D. Newgard et al.

HEALTH AFFAIRS (2013)

Add to Collection

Article Gastroenterology & Hepatology

Circulating Microparticles as Disease-Specific Biomarkers of Severity of Inflammation in Patients With Hepatitis C or Nonalcoholic Steatohepatitis

Miroslaw Kornek et al.

GASTROENTEROLOGY (2012)

Add to Collection

Editorial Material Veterinary Sciences

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

Carol Kilkenny et al.

VETERINARY CLINICAL PATHOLOGY (2012)

Add to Collection

Article Gastroenterology & Hepatology

Human T Cell Microparticles Circulate in Blood of Hepatitis Patients and Induce Fibrolytic Activation of Hepatic Stellate Cells

Miroslaw Kornek et al.

HEPATOLOGY (2011)

Add to Collection

Article Surgery

Survival of the Fittest: The Hidden Cost of Undertriage of Major Trauma

Barbara Haas et al.

JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS (2010)

Add to Collection

Article Critical Care Medicine

The current state in the evaluation and treatment of ARDS and SIRS

Josh E. Schroeder et al.

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED (2009)

Add to Collection

© Peeref 2019-2024. All rights reserved.