Journal
METABOLITES
Volume 13, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/metabo13111140
Keywords
metabolomics; cord blood metabolomics; ASD; autism spectrum disorder; sphingomyelines; non-esterified fatty acids; carnitines
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Autism Spectrum Disorder (ASD) is a diverse neurodevelopmental condition, and metabolomics may help identify underlying metabolic mechanisms contributing to ASD. Lower cord blood concentrations of SM.C.39.2 and NEFA16:1/16:0 were associated with higher autistic traits among 6-year-old children, but no significant associations were found after more stringent adjustment for confounders. Differences in lipid metabolism (SM and NEFA) might be involved in ASD-related pathways and warrant further investigation.
Autism Spectrum Disorder (ASD) is a diverse neurodevelopmental condition. Gene-environmental interactions in early stages of life might alter metabolic pathways, possibly contributing to ASD pathophysiology. Metabolomics may serve as a tool to identify underlying metabolic mechanisms contributing to ASD phenotype and could help to unravel its complex etiology. In a population-based, prospective cohort study among 783 mother-child pairs, cord blood serum concentrations of amino acids, non-esterified fatty acids, phospholipids, and carnitines were obtained using liquid chromatography coupled with tandem mass spectrometry. Autistic traits were measured at the children's ages of 6 (n = 716) and 13 (n = 648) years using the parent-reported Social Responsiveness Scale. Lower cord blood concentrations of SM.C.39.2 and NEFA16:1/16:0 were associated with higher autistic traits among 6-year-old children, adjusted for sex and age at outcome. After more stringent adjustment for confounders, no significant associations of cord blood metabolites and autistic traits at ages 6 and 13 were detected. Differences in lipid metabolism (SM and NEFA) might be involved in ASD-related pathways and are worth further investigation.
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