Spatial confined enzyme-linked immunoassay for ultrasensitive biomarker detection using a microfluidic magnetic delivery disc

Article Chemistry, Analytical

Light-addressable electrochemical immunoassay for multiplexed detection of antigen

Jian Wang et al.

Summary: A universal light-addressable electrochemical immunoassay based on silicon photoelectrodes was proposed for high-throughput and accurate immunoanalysis in diagnostic or biodefense applications.

SENSORS AND ACTUATORS B-CHEMICAL (2023)

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Article Chemistry, Analytical

Microelectromechanical Microsystems-Supported Photothermal Immunoassay for Point-of-Care Testing of Aflatoxin B1 in Foodstuff

Zhichao Yu et al.

Summary: A portable photothermal immunosensing platform supported by a microelectromechanical microsystem (MEMS) was developed for quick and cost-effective identification of acutely toxic and low-fatality mycotoxins, which is critical for reducing population mortality.

ANALYTICAL CHEMISTRY (2023)

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Article Chemistry, Multidisciplinary

Recent progress on microfluidic biosensors for rapid detection of pathogenic bacteria

Gaowa Xing et al.

Summary: This article discusses the advances in bacteria detection using microfluidic biosensors. It introduces typical methods for pathogenic bacteria capture, separation, and detection, as well as key applications of microfluidic biosensor-based rapid bacteria detection. Furthermore, it concludes and discusses possible research prospects in the field of microfluidic biosensors for the rapid detection of pathogenic bacteria.

CHINESE CHEMICAL LETTERS (2022)

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Article Chemistry, Analytical

Contactless Photoelectrochemical Biosensor Based on the Ultraviolet-Assisted Gas Sensing Interface of Three-Dimensional SnS2 Nanosheets: From Mechanism Reveal to Practical Application

Lingting Huang et al.

Summary: This work presents a contactless photoelectrochemical biosensor utilizing an ultraviolet-assisted gas sensor and a homemade three-dimensional SnS2 nanosheet-functionalized interdigitated electrode. The gas responsiveness was found to accelerate and the sensitivity increased using the UV irradiation strategy. The effects of interlayer structure and Schottky heterojunction on the gas-sensitive response were further investigated to reveal the mechanism.

ANALYTICAL CHEMISTRY (2022)

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Article Chemistry, Analytical

Smartphone-Based Electrochemical Immunoassay for Point-of-Care Detection of SARS-CoV-2 Nucleocapsid Protein

Ruijin Zeng et al.

Summary: This study presents a smartphone-based electrochemical immunoassay that is ultrasensitive for rapid, low-cost, and easy detection of the SARS-CoV-2 nucleocapsid protein. The method utilizes the interaction between gold nanoparticles on the electrode surface and antibodies to detect the presence of the protein. Additionally, the method allows for wireless data transmission and calculation of results using a smartphone, making it convenient and efficient.

ANALYTICAL CHEMISTRY (2022)

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Article Chemistry, Analytical

Photoelectrochemical immunoassay for prostate-specific antigen based on gasochromic reaction of Pd-MoO3

Zijian Lv et al.

Summary: In this study, a double-mode visual and PEC immunosensing system was designed for the sensitive detection of prostate-specific antigen (PSA) through gasochromic reaction with Pd-MoO3. Under optimal conditions, the system showed high sensitivity for PSA detection.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

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Article Chemistry, Analytical

Simultaneous SERS-based immunoassay of dual cardiac markers on pump-free hybrid microfluidic chip

Rongke Gao et al.

Summary: We developed a new pump-free hybrid microfluidic chip for simultaneous detection of creatine kinase MB isoenzyme and cardiac troponin cardiac markers. The integration of paper and PDMS microfluidic chip offers portability, low-cost, and high sensitivity.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

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Article Chemistry, Analytical

CRISPR/Cas12a-based photoelectrochemical sensing of microRNA on reduced graphene oxide-anchored Bi2WO6 coupling with catalytic hairpin assembly

Hexiang Gong et al.

Summary: An innovative and generic CRISPR/Cas12a-driven photoelectrochemical biosensing platform was developed for screening microRNA-21. The platform utilizes target-triggered catalytic hairpin assembly and reduced graphene oxide-anchored Bi2WO6 as the photoactive material. The system displayed satisfying photocurrent responses and a low limit of detection, making it suitable for clinical cancer diagnostics and biomolecular research.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

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Article Multidisciplinary Sciences

Research on magnetic bead motion characteristics based on magnetic beads preset technology

Zhao Li et al.

Summary: The magnetic beads preset technology is effective in improving the detection efficiency and accuracy of microfluidic chip. By studying the motion characteristics of preset magnetic beads, better control and success rates can be achieved in microchannel. Experiments and numerical simulations have verified the effectiveness of this technology.

SCIENTIFIC REPORTS (2021)

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Article Health Care Sciences & Services

Dynamic changes in serum IL-6, IL-8, and IL-10 predict the outcome of ICU patients with severe COVID-19

Jia Li et al.

Summary: Dynamic changes in serum levels of IL-6, IL-8, and IL-10 were associated with survival in patients in the ICU with severe COVID-19, serving as predictive biomarkers to guide treatment options.

ANNALS OF PALLIATIVE MEDICINE (2021)

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Article Engineering, Chemical

Mathematical modeling of the droplet formation process in a microfluidic device

S. D. Svetlov et al.

Summary: The paper describes the results of droplet formation modeling in a microfluidic device based on the force balance method, using Navier-Stokes and continuity equations. The study shows that the continuous phase flow rate significantly influences the hydrodynamic situation, while the dispersed phase viscosity has a stronger impact on the position of flow regimes boundaries.

CHEMICAL ENGINEERING SCIENCE (2021)

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Article Chemistry, Analytical

Microfluidic Magnetic Analyte Delivery Technique for Separation, Enrichment, and Fluorescence Detection of Ultratrace Biomarkers

Jiani Yang et al.

Summary: The μMAD technique combines functionalized magnetic beads and a microfluidic device for ultra-sensitive biomarker detection and sample preparation, providing a valuable approach for trace-level biomarker detection in practical applications.

ANALYTICAL CHEMISTRY (2021)

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Article Cell Biology

Self-Assembled Permanent Micro-Magnets in a Polymer-Based Microfluidic Device for Magnetic Cell Sorting

Lucie Descamps et al.

Summary: Magnetophoresis-based microfluidic devices allow for simple manipulation of micro-scale objects, especially with the integration of micrometer-scale permanent magnets made from NdFeB particles. These micro-magnets not only exhibit strong trapping capabilities but also enhance magnetic forces for efficient cell sorting and high-throughput sorting applications.

CELLS (2021)

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Article Biophysics