Photoredox-catalyzed difunctionalization of alkenes with oxime esters and NH-sulfoximines

A visible-light-induced one-pot three-component reaction of cycloketone oxime esters, NH-sulfoximines, and alkenes was developed for the difunctionalization of alkenes. As a result, a series of versatile sulfoximido-cyanoalkylative products were synthesized under mild and sustainable reaction conditions (up to 98% yield). The significance of this protocol was highlighted by excellent regioselectivity, broad substrate scope, and excellent synthetic applications. A visible-light-induced one-pot three-component reaction of cycloketone oxime esters, NH-sulfoximines, and alkenes was developed for the difunctionalization of alkenes.

Automated summary

A visible-light-induced one-pot three-component reaction was developed for the difunctionalization of alkenes. It showed excellent regioselectivity, broad substrate scope, and high synthetic yield, leading to the synthesis of versatile sulfoximido-cyanoalkylative products.