Four New Pentacyclic Triterpene Glycosides Isolated from the Fruits of Cryptolepis buchananii R.Br. ex Roem. & Schult and Their Inhibition of NO Production in LPS-activated RAW264.7 Cells

Article Biochemistry & Molecular Biology

Five New Oleanane Triterpene Saponins from Camellia petelotii and Their Alpha-glucosidase Inhibitory Activity

Nguyen Thi Cuc et al.

Summary: Five new triterpenoid glycosides, named campetelosides A-E (1-5), along with three known compounds, were isolated from Camellia petelotii leaves. Their chemical structures were determined using HR-ESI-MS and NMR spectra. Compounds 1-3 exhibited significant α-glucosidase inhibitory activity with IC50 values of 166.7 +/- 6.0 μM, 45.9 +/- 2.6 μM, and 395.3 +/- 10.5 μM, respectively, compared to the positive control acarbose (IC50 value of 200.4 +/- 10.5 μM).

CHEMISTRY & BIODIVERSITY (2023)

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Article Biochemistry & Molecular Biology

Dimethylbutyrylated Dibenzocyclooctadiene Lignans from the Fruits of Schisandra cauliflora Inhibit NO Production in LPS-Activated RAW264.7 Cells

Pham Hai Yen et al.

Summary: Five new dimethylbutyrylated dibenzocyclooctadiene lignans, named schisandracaurins A-E, were isolated from Schisandra cauliflora using separation and chromatographic techniques. Their structures were determined by extensive analyses of HR-ESI-MS, NMR, and ECD spectra. The schisandracaurins A-E potentially inhibited NO production in LPS-activated RAW264.7 cells with their IC50 values ranging from 21.4 to 30.3 μM.

CHEMISTRY & BIODIVERSITY (2023)

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Article Plant Sciences

The Cytotoxic Cardiac Glycoside (-)-Cryptanoside A from the Stems of Cryptolepis dubia and Its Molecular Targets

Yulin Ren et al.

Summary: A cardiac glycoside epoxide, (-)-cryptanoside A (1), was isolated from Cryptolepis dubia and showed potent cytotoxicity against various human cancer cell lines. It also inhibited Na+/K+-ATPase activity and increased the expression of Akt and the p65 subunit of NF-κB. Molecular docking analysis suggested that (-)-cryptanoside A (1) directly targets Na(+)/K+-ATPase to exhibit its cytotoxic effects on cancer cells.

JOURNAL OF NATURAL PRODUCTS (2023)

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Article Biochemistry & Molecular Biology

Undescribed 2,9-deoxyflavonoids and flavonol-diamide [3+2] adduct from the leaves of Aglaia odorata Lour. Inhibit nitric oxide production

Pham Hai Yen et al.

Summary: Phytochemical study of Aglaia odorata leaves resulted in the isolation of four previously undescribed compounds, including three 2,9-deoxyflavonoids and one flavonol-diamide [3 + 2] adduct, as well as 13 known compounds. The chemical structures of the undescribed compounds were determined through various spectroscopic techniques. The study also revealed a novel 2,9-deoxyflavonoid framework.

PHYTOCHEMISTRY (2023)

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Article Biochemistry & Molecular Biology