Journal
CHEMISTRYSELECT
Volume 8, Issue 45, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.202304489
Keywords
cannabinoids; synthetic cannabinoids; cannabidiol metabolites; total synthesis; hydroxycannabidiol derivatives
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This study presents a new practical and efficient multistep synthesis method for the production of 1- and 2-hydroxycannabidiol metabolites. The target metabolites were successfully produced with good overall yields, and the reactions are easily feasible.
Herein we report a new practical and efficient multistep syntheses of 1- and 2-hydroxycannabidiol metabolites. Both products and intermediates were fully characterized, and the target metabolites were produced in good overall yields. A new multistep protocol, comprising four steps, was implemented to prepare 1-hydroxycannabidiol and 2-hydroxycannabidiol, two of the most important and investigated hydroxylated cannabidiol metabolites. The reactions are easily feasible, and metabolites were isolated, in 24 % and 28 % of overall yield respectively, as mixtures of epimers.image
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