Journal
ORGANIC LETTERS
Volume 25, Issue 46, Pages 8350-8355Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.3c03473
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Here, we describe a metal-free approach using an electron donor-acceptor (EDA) complex, for the cross-coupling of arenes or styryl-thianthrenium salts (TTs) with diarylphosphines. This method offers high site selectivity and good functional group tolerance, enabling the straightforward construction of C-P bonds via C-H activation of arenes and facilitating late-stage functionalization of natural products or pharmaceutical molecules.
Herein, we describe a metal-free approach for the cross-coupling of arenes or styryl-thianthrenium salts (TTs) with diarylphosphines via an electron donor-acceptor (EDA) complex. Various tertiary phosphines were obtained with high site selectivity and good functional group tolerance. This method enables straightforward construction of C-P bonds via C-H activation of arenes and allows the late-stage functionalization of natural products or pharmaceutical molecules. Mechanistic studies support the approach involving a photoinduced EDA complex.
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