Journal
TOXINS
Volume 8, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/toxins8100278
Keywords
spores of Ganoderma lucidum; oxidative stress; aflatoxins; antioxidant capability
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Funding
- Program for New Century Excellent Talents in the University [NCET-13-0558]
- Public sector (Agriculture) scientific research of China [201403047]
- National Key Technology Research and Development Program of China [2012BAD39B00, 2011BAD26B04]
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This study was conducted to investigate the toxic effects of aflatoxin B-1 (AFB(1)) and evaluate the effects of sporoderm-broken spores of Ganoderma lucidum (SSGL) in relieving aflatoxicosis in broilers. A total of 300 one-day-old male Arbor Acre broiler chickens were randomly divided into four dietary treatments; the treatment diets were: Control (a basal diet containing normal peanut meal); AFB(1) (the basal diet containing AFB(1)-contaminated peanut meal); SSGL (basal diet with 200 mg/kg of SSGL); AFB(1)+SSGL (supplementation of 200 mg/kg of SSGL in AFB(1) diet). The contents of AFB(1) in AFB(1) and AFB(1)+SSGL diets were 25.0 mu g/kg in the starter period and 22.5 mu g/kg in the finisher period. The results showed that diet contaminated with a low level of AFB(1) significantly decreased (p < 0.05) the average daily feed intake and average daily gain during the entire experiment and reduced (p < 0.05) serum contents of total protein IgA and IgG. Furthermore, a dietary low level of AFB(1) not only increased (p < 0.05) levels of hydrogen peroxide and lipid peroxidation, but also decreased (p < 0.05) total antioxidant capability, catalase, glutathione peroxidase, and hydroxyl radical scavenger activity in the liver and spleen of broilers. Moreover, the addition of SSGL to AFB(1)-contaminated diet counteracted these negative effects, indicating that SSGL has a protective effect against aflatoxicosis.
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