Journal
TOXINS
Volume 8, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/toxins8070220
Keywords
CDT toxin; CDT-producing bacteria; DNA damage
Categories
Funding
- Ministere de la Recherche et de la Technologie
- Institut national de la sante et de la recherche medicale (INSERM) [UMR 1071]
- Institut national de la recherche agronomique (INRA) [USC 2018]
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Cytolethal distending toxin (CDT) is found in Gram-negative bacteria, especially in certain Proteobacteria such as the Pasteurellaceae family, including Haemophilus ducreyi and Aggregatibacter (Actinobacillus) actinomycetemcomitans, in the Enterobacteriaceae family and the Campylobacterales order, including the Campylobacter and Helicobacter species. In vitro and in vivo studies have clearly shown that this toxin has a strong effect on cellular physiology (inflammation, immune response modulation, tissue damage). Some works even suggest a potential involvement of CDT in cancers. In this review, we will discuss these different aspects.
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