Related references
Note: Only part of the references are listed.Evaluating orthogonality between ion-pair reversed phase, anion exchange, and hydrophilic interaction liquid chromatography for the separation of synthetic oligonucleotides
Matthew J. Sorensen et al.
JOURNAL OF CHROMATOGRAPHY A (2023)
Characterization of antisense oligonucleotide and guide ribonucleic acid diastereomers by hydrophilic interaction liquid chromatography coupled to mass spectrometry
Alexandre Goyon et al.
JOURNAL OF CHROMATOGRAPHY A (2023)
Control of backbone chemistry and chirality boost oligonucleotide splice switching activity
Pachamuthu Kandasamy et al.
NUCLEIC ACIDS RESEARCH (2022)
Effect of ion-pairing reagent hydrophobicity on liquid chromatography and mass spectrometry analysis of oligonucleotides
Michael Donegan et al.
JOURNAL OF CHROMATOGRAPHY A (2022)
Contribution of ionic interactions to stationary phase selectivity in hydrophilic interaction chromatography
Martin Gilar et al.
JOURNAL OF SEPARATION SCIENCE (2022)
Cholesterol Stationary Phase in the Separation and Identification of siRNA Impurities by Two-Dimensional Liquid Chromatography-Mass Spectrometry
Sylwia Studzinska et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)
Phosphorothioate oligonucleotides separation in ion-pairing reversed-phase liquid chromatography: Effect of ion-pairing system
Zuzana Kadlecova et al.
JOURNAL OF CHROMATOGRAPHY A (2022)
The impact of low adsorption surfaces for the analysis of DNA and RNA oligonucleotides
Honorine Lardeux et al.
JOURNAL OF CHROMATOGRAPHY A (2022)
Phosphorothioate oligonucleotides separation in ion-pairing reversed-phase liquid chromatography: effect of temperature
Zuzana Kadlecova et al.
JOURNAL OF CHROMATOGRAPHY A (2022)
Separation of phosphorothioate oligonucleotide impurities by WAX HPLC under high organic content elution conditions
Stilianos G. Roussis et al.
ANALYTICAL BIOCHEMISTRY (2022)
Characterization of Impurities in Therapeutic RNAs at the Single Nucleotide Level
Alexandre Goyon et al.
ANALYTICAL CHEMISTRY (2022)
Characterizing the Diastereoisomeric Distribution of Phosphorothioate Oligonucleotides by Metal Ion Complexation Chromatography, In-Series Reversed Phase-Strong Anion Exchange Chromatography, and 31P NMR
Stilianos G. Roussis et al.
ANALYTICAL CHEMISTRY (2021)
Impact of Nonspecific Adsorption to Metal Surfaces in Ion Pair-RP LC-MS Impurity Analysis of Oligonucleotides
Guilherme J. Guimaraes et al.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2021)
Using Hybrid Organic-Inorganic Surface Technology to Mitigate Analyte Interactions with Metal Surfaces in UHPLC
Mathew DeLano et al.
ANALYTICAL CHEMISTRY (2021)
Mitigation of analyte loss on metal surfaces in liquid chromatography
Martin Gilar et al.
JOURNAL OF CHROMATOGRAPHY A (2021)
From Antisense RNA to RNA Modification: Therapeutic Potential of RNA-Based Technologies
Hironori Adachi et al.
BIOMEDICINES (2021)
Evaluating the interplay among stationary phases/ion-pairing reagents/ sequences for liquid chromatography mass spectrometry analysis of oligonucleotides
Xiaochan Chen et al.
ANALYTICAL BIOCHEMISTRY (2021)
Assessing the impact of nonspecific binding on oligonucleotide bioanalysis
Jennifer M. Nguyen et al.
BIOANALYSIS (2021)
Evaluation of hydrophilic interaction liquid chromatography, capillary zone electrophoresis and drift tube ion-mobility quadrupole time of flight mass spectrometry for the characterization of phosphodiester and phosphorothioate oligonucleotides
Alice Demelenne et al.
JOURNAL OF CHROMATOGRAPHY A (2020)
Development of an ICP-MS/MS approach for absolute quantification and determination of phosphodiester to phosphorothioate ratio in therapeutic oligonucleotides
Juliusz Bianga et al.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2020)
Therapeutic siRNA: state of the art
Bo Hu et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)
Oligonucleotide analysis by hydrophilic interaction liquid chromatography-mass spectrometry in the absence of ion-pair reagents
Peter A. Lobue et al.
JOURNAL OF CHROMATOGRAPHY A (2019)
Semi-quantitative determination of co-eluting impurities in oligonucleotide drugs using ion-pair reversed-phase liquid chromatography mass spectrometry
Stilianos G. Roussis et al.
JOURNAL OF CHROMATOGRAPHY A (2019)
Alkylamine ion-pairing reagents and the chromatographic separation of oligonucleotides
Ning Li et al.
JOURNAL OF CHROMATOGRAPHY A (2018)
Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides
Naoki Iwamoto et al.
NATURE BIOTECHNOLOGY (2017)
Nucleic acid separations using superficially porous silica particles
Elizabeth D. Close et al.
JOURNAL OF CHROMATOGRAPHY A (2016)
Phosphorothioates, Essential Components of Therapeutic Oligonucleotides
Fritz Eckstein
NUCLEIC ACID THERAPEUTICS (2014)
Comprehensive hydrophilic interaction and ion-pair reversed-phase liquid chromatography for analysis of di- to deca-oligonucleotides
Qin Li et al.
JOURNAL OF CHROMATOGRAPHY A (2012)
Separation of oligonucleotide phosphorothioate diastereoisomers by pellicular anion-exchange chromatography
James R. Thayer et al.
JOURNAL OF CHROMATOGRAPHY A (2011)
Chromatographic selectivity triangles
Andrew R. Johnson et al.
JOURNAL OF CHROMATOGRAPHY A (2011)
Utility of Retention Prediction Model for Investigation of Peptide Separation Selectivity in Reversed-Phase Liquid Chromatography: Impact of Concentration of Trifluoroacetic Acid, Column Temperature, Gradient Slope and Type of Stationary Phase
Martin Gilar et al.
ANALYTICAL CHEMISTRY (2010)
Reversed-phase ion-pair liquid chromatography analysis and purification of small interfering RNA
Sean M. McCarthy et al.
ANALYTICAL BIOCHEMISTRY (2009)
Peak capacity in gradient reversed-phase liquid chromatography of biopolymers Theoretical and practical implications for the separation of oligonucleotides
Martin Gilar et al.
JOURNAL OF CHROMATOGRAPHY A (2007)
A statistical learning approach to the modeling of chromatographic retention of oligonucleotides incorporating sequence and secondary structure data
Marc Sturm et al.
NUCLEIC ACIDS RESEARCH (2007)
Purification of dye-labeled oligonucleotides by ion-pair reversed-phase high-performance liquid chromatography
KJ Fountain et al.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2003)
Analysis of native and chemically modified oligonucleotides by tandem ion-pair reversed-phase high-performance liquid chromatography/electrospray ionization mass spectrometry
KJ Fountain et al.
RAPID COMMUNICATIONS IN MASS SPECTROMETRY (2003)
Characterization of therapeutic oligonucleotides using liquid chromatography with on-line mass spectrometry detection
M Gilar et al.
OLIGONUCLEOTIDES (2003)
Ion-pair reversed-phase high-performance liquid chromatography analysis of oligonucleotides: Retention prediction
M Gilar et al.
JOURNAL OF CHROMATOGRAPHY A (2002)
Analysis and purification of synthetic oligonucleotides by reversed-phase high-performance liquid chromatography with photodiode array and mass spectrometry detection
M Gilar
ANALYTICAL BIOCHEMISTRY (2001)
Large-scale purification of antisense oligonucleotides by high-performance membrane adsorber chromatography
RR Deshmukh et al.
JOURNAL OF CHROMATOGRAPHY A (2000)
Phosphorothioate oligodeoxynucleotides: What is their origin and what is unique about them?
F Eckstein
ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT (2000)