4.7 Review

Recent developments toward microfluidic point-of-care diagnostic sensors for viral infections

Journal

TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 169, Issue -, Pages -

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2023.117361

Keywords

Microfluidics; Point-of-care diagnostics; Viral infection; Sensing technologies; Materials fabrication techniques

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This review article provides an overview of the application of microfluidics in point-of-care diagnostics, particularly focusing on rapid diagnosis of viral infections. The article introduces the principles of microfluidics, the components of microfluidic devices, and discusses the advantages and disadvantages of microfluidics in diagnostics. It also highlights examples of microfluidic diagnostic devices for viral infections and explores sensing technologies and recent advancements in this field. Additionally, the article describes the materials and fabrication techniques used in microfluidic devices and addresses the challenges in their development as diagnostic sensors.
This review article provides an overview of the application of microfluidics in point-of-care (POC) diagnostics, with a focus on rapid viral infection diagnosis. The introduction defines POC diagnostics and emphasizes the importance of rapid viral infection diagnosis. The history of microfluidics in diagnostics is discussed, along with a comparison to traditional diagnostic techniques. The principles of microfluidics and the basic components of microfluidic devices are presented. The advantages and disadvantages of microfluidics in diagnostics, including rapid diagnosis, low sample volume requirement, and integration with various detection technologies, are discussed. Examples of microfluidic diagnostic devices for viral infections, both commercial and research-based, are highlighted. Sensing technologies for viral infections are also explored, along with recent developments in this field. Moreover, materials and fabrication techniques used in microfluidic devices are described. Recent advancements in materials and fabrication techniques are also discussed. The challenges in microfluidic diagnostic sensor development are addressed too.

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