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The Role of Insulin-like Growth Factor I in Mechanisms of Resilience and Vulnerability to Sporadic Alzheimer's Disease

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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FRONTIERS IN AGING NEUROSCIENCE (2019)

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Insulin/IGF-1 Drives PERIOD Synthesis to Entrain Circadian Rhythms with Feeding Time

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Oscillatory hyperactivity and hyperconnectivity in young APOE-ε4 carriers and hypoconnectivity in Alzheimer's disease

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Serum Insulin-Like Growth Factor I Deficiency Associates to Alzheimer's Disease Co-Morbidities

Jonathan A. Zegarra-Valdivia et al.

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Loss of the interaction between estradiol and insulin-like growth factor I in brain endothelial cells associates to changes in mood homeostasis during peri-menopause in mice

Victor Munive et al.

AGING-US (2019)

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Tau Accumulation in Clinically Normal Older Adults Is Associated with Hippocampal Hyperactivity

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Risk of prevalent and incident dementia associated with insulin-like growth factor and insulin-like growth factor-binding protein 3

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Insulin-like Growth Factor 1 (IGF-1) as a marker of cognitive decline in normal ageing: A review

Julanne Frater et al.

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NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

Clifford R. Jack et al.

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Brain properties predict proximity to symptom onset in sporadic Alzheimer's disease

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Melatonin induces mechanisms of brain resilience against neurodegeneration

Ruben Corpas et al.

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Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

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Resistance vs resilience to Alzheimer disease Clarifying terminology for preclinical studies

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Alzheimer's Disease: From Firing Instability to Homeostasis Network Collapse

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A network of insulin peptides regulate glucose uptake by astrocytes: Potential new druggable targets for brain hypometabolism

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Global Burden of Stroke

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Sleep deprivation and cerebrospinal fluid biomarkers for Alzheimer's disease

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Altered Insulin/Insulin-Like Growth Factor Signaling in a Comorbid Rat model of Ischemia and β-Amyloid Toxicity

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Sleep deprivation and cerebrospinal fluid biomarkers for Alzheimer's disease

Martin Olsson et al.

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Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model

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Vulnerability and resilience to Alzheimer's disease: early life conditions modulate neuropathology and determine cognitive reserve

Sylvie L. Lesuis et al.

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Circulating insulin-like growth factor I modulates mood and is a biomarker of vulnerability to stress: from mouse to man

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Insulin Regulates Astrocytic Glucose Handling Through Cooperation With IGF-I

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Alzheimer's disease and diet: a systematic review

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Cryptochromes regulate IGF-1 production and signaling through control of JAK2-dependent STAT5B phosphorylation

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TRPA1 channels promote astrocytic Ca2+ hyperactivity and synaptic dysfunction mediated by oligomeric forms of amyloid-β peptide

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Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity

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IGF1-Dependent Synaptic Plasticity of Mitral Cells in Olfactory Memory during Social Learning

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Acute exercise does not modify brain activity and memory performance in APP/PS1 mice

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Altered cerebral insulin response in transgenic mice expressing the epsilon-4 allele of the human apolipoprotein E gene

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Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer's disease-like pathology

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On the path to 2025: understanding the Alzheimer's disease continuum

Paul S. Aisen et al.

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Insulin-Like Growth Factor-1 and Neuroinflammation

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Dendritic spines provide cognitive resilience against Alzheimer's disease

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IGF-1: an endogenous link between traumatic brain injury and Alzheimer disease?

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Cerebrovascular disease in ageing and Alzheimer's disease

Seth Love et al.

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The Cellular Phase of Alzheimer's Disease

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The Insulin-Like Growth Factor I Receptor Regulates Glucose Transport by Astrocytes

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Breakdown of the Cerebrovasculature and Blood-Brain Barrier: A Mechanistic Link Between Diabetes Mellitus and Alzheimer's Disease

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Age-dependent alterations to paraventricular nucleus insulin-like growth factor 1 receptor as a possible link between sympathoexcitation and inflammation

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Type 2 diabetes mellitus is associated with brain atrophy and hypometabolism in the ADNI cohort

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IGF-1 Receptor Differentially Regulates Spontaneous and Evoked Transmission via Mitochondria at Hippocampal Synapses

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IGF-1 protects dopamine neurons against oxidative stress: association with changes in phosphokinases

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Traumatic brain injury as a risk factor for Alzheimer's disease: current knowledge and future directions

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Summary of the evidence on modifiable risk factors for cognitive decline and dementia: A population-based perspective

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Alzheimer-associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation

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Hyperglycemia modulates extracellular amyloid-β concentrations and neuronal activity in vivo

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Posttraumatic Stress Disorder-Like Induction Elevates β-Amyloid Levels, Which Directly Activates Corticotropin-Releasing Factor Neurons to Exacerbate Stress Responses

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Blocking IGF Signaling in Adult Neurons Alleviates Alzheimer's Disease Pathology through Amyloid-β Clearance

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IGF-1R Reduction Triggers Neuroprotective Signaling Pathways in Spinal Muscular Atrophy Mice

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Immune attack: the role of inflammation in Alzheimer disease

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Personalized Medicine for Effective Alzheimer Disease Treatment

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Human ApoE Isoforms Differentially Modulate Glucose and Amyloid Metabolic Pathways in Female Brain: Evidence of the Mechanism of Neuroprotection by ApoE2 and Implications for Alzheimer's Disease Prevention and Early Intervention

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Reductions in serum IGF-1 during aging impair health span

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Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease

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Insulin-Like Growth Factor-I Receptor Stimulating Activity is Associated with Dementia

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Symptom onset in autosomal dominant Alzheimer disease A systematic review and meta-analysis

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Interstitial fluid drainage is impaired in ischemic stroke and Alzheimer's disease mouse models

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Dissecting phenotypic traits linked to human resilience to Alzheimer's pathology

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Hypoglycemia Induces Tau Hyperphosphorylation

Chu-Wan Lee et al.

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Loss of serum IGF-I input to the brain as an early biomarker of disease onset in Alzheimer mice

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The Association Between IGF-I and Insulin Resistance A general population study in Danish adults

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Reduced brain insulin-like growth factor I function during aging

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Regulation of the phosphatase calcineurin by insulin-like growth factor I unveils a key role of astrocytes in Alzheimer's pathology

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The many faces of insulin-like peptide signalling in the brain

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Insulin-like growth factor 1 (IGF1) polymorphism is associated with Alzheimer's disease in Han Chinese

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Frequent Cognitive Activity Compensates for Education Differences in Episodic Memory

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Effects of Aerobic Exercise on Mild Cognitive Impairment A Controlled Trial

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Traumatic brain injury and amyloid-beta pathology: a link to Alzheimer's disease?

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Neuronal Activity Drives Localized Blood-Brain-Barrier Transport of Serum Insulin-like Growth Factor-I into the CNS

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A Kinase-Independent Role for Unoccupied Insulin and IGF-1 Receptors in the Control of Apoptosis

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Reduced IGF-1 Signaling Delays Age-Associated Proteotoxicity in Mice

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β-Amyloid Oligomers Induce Phosphorylation of Tau and Inactivation of Insulin Receptor Substrate via c-Jun N-Terminal Kinase Signaling: Suppression by Omega-3 Fatty Acids and Curcumin

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β-Amyloid deposition in brains of subjects with diabetes

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Circulating insulin-like growth factor I and cognitive function: Neuromodulation throughout the lifespan

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Amyloid-β Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle

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Synchronous Hyperactivity and Intercellular Calcium Waves in Astrocytes in Alzheimer Mice

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The amyloidogenic potential and behavioral correlates of stress

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Enhanced risk for Alzheimer disease in persons with type 2 diabetes and APOE epsilon 4

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Cognitive dysfunction and diabetes mellitus

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Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease

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Central actions of liver-derived insulin-like growth factor I underlying its pro-cognitive effects

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Inflammatory changes parallel the early stages of Alzheimer disease

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Education and dementia - What lies behind the association?

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Calcineurin in reactive astrocytes plays a key role in the interplay between proinflammatory and anti-inflammatory signals

Ana M. Fernandez et al.

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Utility of free IGF-I measurements

Jan Frystyk

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Normal levels of serum IGF-I: determinants and validity of current reference ranges

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IGF-1-induced processing of the amyloid precursor protein family is mediated by different signaling pathways

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Disturbed cross talk between insulin-like growth factor I and AMP-activated protein kinase as a possible cause of vascular dysfunction in the amyloid precursor protein/presenilin 2 mouse model of Alzheimer's disease

Cristina Lopez-Lopez et al.

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Cognitive and physical activity differently modulate disease progression in the amyloid precursor protein (APP)-23 model of Alzheimer's disease

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Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression

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Central and opposing effects of IGF-I and IGF-binding protein-3 on systemic insulin action

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Involvement of oxidative stress in Alzheimer disease

Akihiko Nunomura et al.

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Specimen processing time and measurement of total insulin-like growth factor-I (IGF-I), free IGF-I, and IGF binding protein-3 (IGFBP-3)

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Tau is hyperphosphorylated in the insulin-like growth factor-I null brain

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Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease

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The role of insulin and insulin-like growth factor I in the molecular and cellular mechanisms underlying the pathology of Alzheimer's disease

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Increased risk of type 2 diabetes in Alzheimer disease

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Insulin-like growth factor I is required for vessel remodeling in the adult brain

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ApoE genotype accounts for the vast majority of AD risk and AD pathology

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Proneness to psychological distress is associated with risk of Alzheimer's disease

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Stroke and the risk of Alzheimer disease

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IGF-I has a direct proliferative effect in adult hippocampal progenitor cells

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Inflammation in neurodegenerative disease - A double-edged sword

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Medicine - The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics

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IGF-I and microglia/macrophage proliferation in the ischemic mouse brain

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Circulating concentrations of insulin-like growth factor-I and development of glucose intolerance: a prospective observational study

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Circulating insulin-like growth factor I mediates the protective effects of physical exercise against brain insults of different etiology and anatomy

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Insulin and IGF-1 stimulate the β-catenin pathway through two signalling cascades involving GSK-3β inhibition and Ras activation

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Cerebral amyloidosis, amyloid angiopathy, and their relationship to stroke and dementia

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Insulin-like growth factor-I promotes neurogenesis and synaptogenesis in the hippocampal dentate gyrus during postnatal development

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Insulin-like growth factor 1 regulates developing brain glucose metabolism

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