4.7 Article

High-efficiency inertial focusing based on enhanced secondary flow generated by ring-inner obstacle combined channels

Related references

Note: Only part of the references are listed.
Article Nanoscience & Nanotechnology

Experimental study on inertial focusing pattern in asymmetric contraction-expansion array microchannel

Guorui Zhu et al.

Summary: This study investigated the transition of particle equilibrium pattern in a contraction-expansion array microchannel and identified a novel trajectory. The effects of cavity dimension, Reynolds number, and particle diameter on particle focusing pattern were explored. The critical Reynolds number for pattern transition was summarized, providing guidance for the design of microfluidic particle manipulation techniques.

MICROFLUIDICS AND NANOFLUIDICS (2022)

Article Nanoscience & Nanotechnology

Inertial focusing and filtration of microparticles with expansion-contraction structures in microchannel

Skinder Ali Dar et al.

Summary: In this study, a microfluidic device with expansion-contraction structures was proposed to achieve single focusing and filtration of microparticles in different sizes. The device showed high focusing efficiency and filtration efficiency, and was able to focus and filter specific size microparticles from mixtures effectively.

MICROFLUIDICS AND NANOFLUIDICS (2022)

Article Chemistry, Analytical

Flow-rate and particle-size insensitive inertial focusing in dimension-confined ultra-low aspect ratio spiral microchannel

Lei Zhao et al.

Summary: A novel microchannel structure was developed for flow-rate and particle-size insensitive inertial focusing; efficient focusing of particles and tumor cells at different flow rates was achieved through enhanced secondary flow; providing important reference for the development of portable inertial microfluidic devices.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

Article Biochemical Research Methods

Inertial microfluidics: current status, challenges, and future opportunities

Nan Xiang et al.

Summary: Inertial microfluidics is a technique that utilizes hydrodynamic effects induced at finite Reynolds numbers to passively manipulate particles, cells, or fluids. It offers advantages such as high-throughput processing, simple channel geometry, and label-free and external field-free operation. It has gained increasing interest and is widely used in single-cell detection and analysis for sample preparation. Although there have been achievements in the field, improvements can still be made in the performance and outcomes of inertial microfluidics with a better understanding of the physical mechanisms and the development of novel channels, integration strategies, and commercial instruments. Enhanced inertial microfluidic platforms may be a new foundation for advancing biomedical research and disease diagnosis.

LAB ON A CHIP (2022)

Article Biochemical Research Methods

Laser particle activated cell sorting in microfluidics

Paul H. Dannenberg et al.

Summary: This article demonstrates a cell barcode technology using laser particles, which can be used for cell sorting and routing through a microfluidic platform integrated with a high-speed spectrometer. By utilizing the spectral emission of laser particles, individual cells labeled with different laser colors can be distinguished and sorted.

LAB ON A CHIP (2022)

Article Biochemical Research Methods

Tuning particle inertial separation in sinusoidal channels by embedding periodic obstacle microstructures

Haotian Cha et al.

Summary: Inertial microfluidics relies on fluid dynamics at high flow speeds, with channel geometry being the critical design parameter. Four basic channel geometries have been proposed and studied extensively. This work explores embedding periodic concave and convex obstacle microstructures in sinusoidal channels, investigating their impact on particle inertial focusing and separation. The results suggest that embedding microstructures brings flexibility to device design and enables high-performance separation.

LAB ON A CHIP (2022)

Article Biochemical Research Methods

High-throughput and label-free enrichment of malignant tumor cells and clusters from pleural and peritoneal effusions using inertial microfluidics

Zhixian Zhu et al.

Summary: A polymer microfluidic chip was used for high-throughput and label-free enrichment of malignant tumor cells from pleural and peritoneal effusions. The enriched tumor cells were successfully purified and could be used for rapid drug sensitivity testing. This approach can accelerate cancer diagnosis and guide treatment medication selection.

LAB ON A CHIP (2022)

Article Chemistry, Multidisciplinary

Label-Free Isolation and Single Cell Biophysical Phenotyping Analysis of Primary Cardiomyocytes Using Inertial Microfluidics

Hossein Tavassoli et al.

Summary: A label-free method using inertial microfluidics is developed to purify viable cardiomyocytes from mouse neonatal hearts with purities over 90%. The isolated cardiomyocytes retain their identity and function, exhibiting different physico-mechanical properties compared to non-cardiomyocytes. This method could be a valuable tool for advancing the understanding of cardiomyocyte identity and function, with potential benefits for cell therapy and diagnostic applications.

SMALL (2021)

Article Chemistry, Analytical

Multiplexed serpentine microchannels for high-throughput sorting of disseminated tumor cells from malignant pleural effusion

Hui Ren et al.

Summary: The multiplexed inertial microfluidic devices are proposed and developed for accurate isolation and detection of disseminated tumor cells from the malignant pleural effusion, showing promise for clinical applications due to their simple structure, high throughput, low cost, and good efficiency.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

Article Chemistry, Analytical

Single Cell Metabolite Detection Using Inertial Microfluidics-Assisted Ion Mobility Mass Spectrometry

Leicheng Zhang et al.

Summary: The study proposes a novel strategy integrating spiral inertial microfluidics and ion mobility mass spectrometry for single-cell metabolite detection and identification. The technology successfully screened the metabolic profiles of different types of cancer cells, improving confidence in metabolite identification. This approach offers a simple and efficient method for single-cell lipid profiling, with additional ion mobility separation significantly enhancing the confidence toward identification of metabolites.

ANALYTICAL CHEMISTRY (2021)

Review Biochemical Research Methods

Inertial microfluidics in contraction-expansion microchannels: A review

Di Jiang et al.

Summary: Inertial microfluidics has become a major trend in sample pretreatment, with contraction-expansion microchannels enhancing the efficiency of inertial microfluidics and allowing for more precise particle separation using vortex and secondary flow. Recent studies have focused on the use of viscoelastic fluids for precise particle separation at lower flow rates, particularly for delicate cells.

BIOMICROFLUIDICS (2021)

Article Biochemical Research Methods

Inertial focusing of microparticles, bacteria, and blood in serpentine glass channels

Pablo Rodriguez-Mateos et al.

Summary: The early detection of pathogenic microorganisms is crucial for diagnosing and preventing health and safety emergencies. Traditional detection methods rely on time-consuming culturing procedures and biochemical assays, taking over 24 hours for a diagnosis. The main challenge lies in the low concentration of pathogens within complex samples. Inertial microfluidic manipulation in curved glass channels shows promise for automating and parallelizing particle and cell separation.

ELECTROPHORESIS (2021)

Article Multidisciplinary Sciences

An unrecognized inertial force induced by flow curvature in microfluidics

Siddhansh Agarwal et al.

Summary: This literature introduces an analytical method in inertial microfluidics to derive and quantify the theory of inertial effects, which has been verified through full-scale, three-dimensional direct numerical simulations and revealed previously unexplained experimental phenomena.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Biochemical Research Methods

Inertial focusing of circulating tumor cells in whole blood at high flow rates using the microfluidic CTCKey™ device for CTC enrichment

Kaylee Judith Smith et al.

Summary: CTCs are rare cells shed from tumors into the blood stream, providing valuable information for treatment decisions. Current technologies face difficulties in isolating enough CTCs for in-depth tumor analysis, prompting the development of the CTCKey(TM) for efficient focusing of CTCs in whole blood.

LAB ON A CHIP (2021)

Article Biochemical Research Methods

Sheathless and high-throughput elasto-inertial bacterial sorting for enhancing molecular diagnosis of bloodstream infection

Xiaoguang Lu et al.

Summary: A novel inertial microfluidic method has been developed to effectively sort bacteria from larger blood cells, improving pathogen detection efficiency and accuracy.

LAB ON A CHIP (2021)

Article Chemistry, Analytical

High efficiency rare sperm separation from biopsy samples in an inertial focusing device

Haidong Feng et al.

Summary: A high recovery, high throughput sperm separation process is proposed for clinical biopsy sperm retrieval, achieving a 95.6% sperm recovery with 87.4% removal of non-sperm cells. The chance of finding sperm in treated samples increases by 8.2 fold, supporting the development of a rapid biopsy sperm sorting process. The mechanism can also be applied for high-efficiency separation of non-spherical particles in general.

ANALYST (2021)

Review Chemistry, Analytical

A Review of Secondary Flow in Inertial Microfluidics

Qianbin Zhao et al.

MICROMACHINES (2020)

Review Biochemical Research Methods

Inertial microfluidics: Recent advances

Di Huang et al.

ELECTROPHORESIS (2020)

Review Biochemical Research Methods

Channel innovations for inertial microfluidics

Wenlai Tang et al.

LAB ON A CHIP (2020)

Article Engineering, Electrical & Electronic

Tape'n roll inertial microfluidics

Mohammad Asghari et al.

SENSORS AND ACTUATORS A-PHYSICAL (2019)

Article Chemistry, Analytical

River meander-inspired cross-section in 3D-printed helical microchannels for inertial focusing and enrichment

Zezhou Chen et al.

SENSORS AND ACTUATORS B-CHEMICAL (2019)

Article Biochemical Research Methods

Single stream inertial focusing in low aspect-ratio triangular microchannels

Prithviraj Mukherjee et al.

LAB ON A CHIP (2019)

Article Chemistry, Analytical

Negative Selection by Spiral Inertial Microfluidics Improves Viral Recovery and Sequencing from Blood

Kyungyong Choi et al.

ANALYTICAL CHEMISTRY (2018)

Article Nanoscience & Nanotechnology

Inertial focusing of microparticles in curvilinear microchannels with different curvature angles

Arzu Ozbey et al.

MICROFLUIDICS AND NANOFLUIDICS (2018)

Article Engineering, Biomedical

High-Throughput Separation of White Blood Cells From Whole Blood Using Inertial Microfluidics

Jun Zhang et al.

IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS (2017)

Article Nanoscience & Nanotechnology

Particle focusing by 3D inertial microfluidics

Petra Paie et al.

MICROSYSTEMS & NANOENGINEERING (2017)

Review Chemistry, Multidisciplinary

Microfluidic hydrodynamic focusing for synthesis of nanomaterials

Mengqian Lu et al.

NANO TODAY (2016)

Article Biochemical Research Methods

Rapid inertial solution exchange for enrichment and flow cytometric detection of microvesicles

Jaideep S. Dudani et al.

BIOMICROFLUIDICS (2015)

Review Biochemical Research Methods

Inertial microfluidics

Dino Di Carlo

LAB ON A CHIP (2009)

Article Multidisciplinary Sciences

Continuous inertial focusing, ordering, and separation of particles in microchannels

Dino Di Carlo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)