4.1 Review

DNA logic programming: From concept to construction

Related references

Note: Only part of the references are listed.
Article Chemistry, Multidisciplinary

A DNA-based nanodevice for near-infrared light-controlled drug release and bioimaging

Qing Liu et al.

Summary: A near-infrared light-guided DNA nanodevice is developed for precise drug delivery and tumor therapy. The nanodevice consists of GC-rich DNA duplexes with a UV light labile moiety and upconversion nanoparticles. Upon NIR light irradiation, the nanoparticles emit UV light to break the pho-tolabile moiety, resulting in controlled drug release and fluorescence signal recovery. This modular strategy enables remotely controlled drug delivery and in situ imaging.

NANO TODAY (2023)

Article Biochemical Research Methods

A dynamic DNA tetrahedron framework for active targeting

Taoran Tian et al.

Summary: An active targeting strategy-enabled DNA tetrahedron delivery vehicle has been developed for stable drug encapsulation and stimuli-responsive on-demand release, providing a universal platform for various drug delivery requirements.

NATURE PROTOCOLS (2023)

Review Chemistry, Analytical

DNA computational device-based smart biosensors

Mengyao Cao et al.

Summary: DNA computing has made rapid progress in the past decade. DNA computational devices can perform various powerful computational functions based on DNA functional motifs. They have shown great potential in biosensing applications due to the inherent properties of DNA.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2023)

Article Biophysics

Programmable DNA biocomputing circuits for rapid and intelligent screening of SARS-CoV-2 variants

Fang Deng et al.

Summary: In this study, molecular biocomputing circuits were constructed using DNA molecular logic gates, and the logic operation results were monitored using fluorophores. This method enables rapid screening of SARS-CoV-2 variants.

BIOSENSORS & BIOELECTRONICS (2023)

Review Oncology

Development and application of nanomaterials, nanotechnology and nanomedicine for treating hematological malignancies

Jinxin Li et al.

Summary: Hematologic malignancies (HMs) pose a serious threat to patient's health with low overall survival rates. Lack of understanding in pathogenesis and complex clinical symptoms result in significant challenges in diagnosis and treatment. Although traditional therapies and recent advancements like immunotherapy and cell therapy have shown progress, drug resistance and relapse still remain major issues. Recent studies highlight the potential of nanomaterials, nanotechnology, and nanomedicine in enhancing drug targeting, reducing toxicity and side effects, and boosting immune response in cancer therapy. This review summarizes the strategies of nanomaterials in treating HMs and proposes future strategies based on clinical needs and technological progress.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2023)

Article Chemistry, Multidisciplinary

Orthogonal Light-Activated DNA for Patterned Biocomputing within Synthetic Cells

Denis Hartmann et al.

Summary: Cell-free gene expression is a valuable tool for studying biological systems and has potential applications in biotechnology. Controlling DNA templates for cell-free expression is crucial for precise regulation of complex pathways and use with synthetic cells, especially using non-damaging stimuli like visible light. In this study, blue light-activatable DNA parts were synthesized to tightly regulate cell-free RNA and protein synthesis, providing a new approach for precise control of cell-free systems.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2023)

Review Chemistry, Analytical

CRISPR/Cas systems accelerating the development of aptasensors

Chao Zhu et al.

Summary: This review comprehensively summarizes the recent progress of CRISPR/Cas system-based aptasensors (Cas-aptasensors) including their design principles and superior applications. It introduces the essential features of aptamers and the CRISPR/Cas system, outlines the composition of Cas-aptasensors, and emphasizes their fabrication methods, bio-recognition mechanism, and detection evaluation. It also discusses the challenges and future directions for aptamers, CRISPR/Cas systems, and their accelerating applications in Cas-aptasensors.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2023)

Article Biochemistry & Molecular Biology

Combinatorial protein dimerization enables precise multi-input synthetic computations

Adrian Bertschi et al.

Summary: We constructed a framework for multi-input logic gates based on inducible protein-protein interactions by utilizing the modular structure of bacterial transcription factors. We were able to convert gene switches from OFF-type to more widely applicable ON-type systems and create mammalian gene switches responsive to new inducers. By combining both OFF and ON modes of action, we built a compact and high-performance bandpass filter, and demonstrated cytosolic and extracellular dimerization. Cascading up to five pairwise fusion proteins yielded robust multi-input AND logic gates, and combinations of different pairwise fusion proteins afforded a variety of 4-input 1-output AND and OR logic gate configurations.

NATURE CHEMICAL BIOLOGY (2023)

Article Biotechnology & Applied Microbiology

NIR/pH-triggered aptamer-functionalized DNA origami nanovehicle for imaging-guided chemo-phototherapy

Mengyue Li et al.

Summary: Targeted chemo-phototherapy has been widely recognized for its ability to reduce side effects and improve therapeutic effects in cancer treatment. In this study, a novel DNA origami-based nanosystem, called TOADI, was successfully constructed for co-delivery of a chemotherapeutic drug (DOX) and a photosensitizer (ICG) to achieve targeted synergistic chemophototherapy. In vitro and in vivo experiments demonstrated that TOADI exhibited enhanced tumor targeting ability and significant therapeutic effects, resulting in substantial inhibition of tumor growth with minimal systemic toxicity. Furthermore, TOADI showed excellent performance in fluorescence and photothermal imaging. This multifunctional nanosystem provides a promising strategy for enhanced cancer therapy.

JOURNAL OF NANOBIOTECHNOLOGY (2023)

Article Chemistry, Multidisciplinary

Unlocking Genetic Profiles with a Programmable DNA-Powered Decoding Circuit

Junlan Liu et al.

Summary: Human genetic architecture provides insights into disease risk prediction and personalized medication. A DNA-based intelligent decoder has been engineered to automate clinical analyses and interpretations, converting complex genetic profiles into actionable healthcare decisions. The decoder performs intended computations on genetic profiles and outputs corresponding answers within hours. It is validated to achieve desirable performance in interpreting genetic profiles for drug responses and can be reprogrammed for other pharmacogenetics genes and risk assessments for personalized healthcare.

ADVANCED SCIENCE (2023)

Review Chemistry, Multidisciplinary

Overcoming Pharmaceutical Bottlenecks for Nucleic Acid Drug Development

Mei Lu et al.

Summary: The COVID-19 pandemic and mRNA vaccine development have brought nucleic acid therapeutics to the forefront. Nucleic acid drugs have shown promise in treating diseases at the genetic level, offering new treatment options and vaccine development against emerging health threats. However, challenges such as unfavorable physicochemical characteristics and off-target toxicity need to be addressed to advance nucleic acid therapeutics from the laboratory to clinical use.

ACCOUNTS OF CHEMICAL RESEARCH (2023)

Editorial Material Biotechnology & Applied Microbiology

Leveraging nature to advance data storage: DNA as a storage medium

Kaleb Z. Abram et al.

MICROBIAL BIOTECHNOLOGY (2023)

Article Multidisciplinary Sciences

DNA-based programmable gate arrays for general-purpose DNA computing

Hui Lv et al.

Summary: We demonstrate a general-purpose DNA integrated circuit (DIC) system by integrating multilayer DNA-based programmable gate arrays (DPGAs), which can be reconfigured and programmed to implement a wide range of circuits. We also show that DNA origami registers can control the asynchronous execution of cascaded DPGAs, and the integration of a DPGA with an analog-to-digital converter can be used for disease classification.

NATURE (2023)

Article Chemistry, Multidisciplinary

Polyhydroxylated Organic Molecular Additives for Durable Aqueous Zinc Battery

Huan Liu et al.

Summary: Trehalose, as an electrolyte additive, can improve the stability of the zinc anode, promote planar zinc deposition, and increase the cycle life of the battery.

ADVANCED FUNCTIONAL MATERIALS (2023)

Article Environmental Sciences

Integrating CRISPR-Cas12a with catalytic hairpin assembly as a logic gate biosensing platform for the detection of polychlorinated biphenyls in water samples

Fang Deng et al.

Summary: This work proposed a logic gate biosensing platform for simultaneous detection of multiple polychlorinated biphenyls (PCBs). The platform has the advantages of multiple combinations of inputs, intuitive digital output, and high flexibility and scalability, which holds great promise for the intelligent detection of different PCBs.

SCIENCE OF THE TOTAL ENVIRONMENT (2023)

Article Chemistry, Multidisciplinary

Cooperative Branch Migration: A Mechanism for Flexible Control of DNA Strand Displacement

Zhi Weng et al.

Summary: In this study, a regulatory tool called cooperative branch migration (CBM) is introduced to flexibly control DNA strand displacement by regulating the complementarity of branch migration domains. CBM exhibits multifunctional regulatory abilities, including rate fine-tuning and continuous dynamic regulation.

ACS NANO (2022)

Article Chemistry, Multidisciplinary

Biomimetic Nanoerythrosome-Coated Aptamer-DNA Tetrahedron/Maytansine Conjugates: pH-Responsive and Targeted Cytotoxicity for HER2-Positive Breast Cancer

Wenjuan Ma et al.

Summary: DNA materials have been used as nanocarriers for targeted cancer therapy, but their short half-life and low bioavailability hinder their clinical translation. This study developed a HER2-targeted DNA-aptamer-modified DNA tetrahedron/DM1 conjugate, and applied a biomimetic camouflage to enhance drug delivery and tumor-stimulated drug release. The hybrid erythrosome-based nanoparticles exhibited superior inhibition of HER2-positive cancer.

ADVANCED MATERIALS (2022)

Article Chemistry, Physical

Tetrahedral DNA mediated direct quantification of exosomes by contact-electrification effect

Peng Miao et al.

Summary: This study introduces a triboelectric sensing strategy for direct quantification of exosomes based on the contact-electrification effect. The method shows high sensitivity and a wide linear range, making it suitable for complex biological systems.

NANO ENERGY (2022)

Article Engineering, Biomedical

Nanomaterial-based biosensor developing as a route toward in vitro diagnosis of early ovarian cancer

Yuqi Yang et al.

Summary: The challenges in early diagnosis of ovarian cancer have led to a high mortality rate. The progress in nanomaterials and discovery of new biomarkers offer improvements in convenience, speed, selectivity, and sensitivity for early ovarian cancer diagnosis. This review summarizes the limitations of commercial ovarian cancer biosensors, discusses optimization strategies for potential biomarkers, and introduces emerging biosensors based on nanomaterials.

MATERIALS TODAY BIO (2022)

Article Chemistry, Multidisciplinary

Stable Universal 1-and 2-Input Single-Molecule Logic Gates

Ran Liu et al.

Summary: This study presents a controllable ultra-minimalistic circuit element using single-molecule logic operations, which requires stable currents from multiple orthogonal inputs. By modulating the output current in real-time based on orthogonal input bias and gate voltages, reliable and low-voltage operations are achieved. Various logic gates are successfully implemented, demonstrating stable multilogic operations.

ADVANCED MATERIALS (2022)

Article Biophysics

Electrochemical label-free biomolecular logic gates regulated by distinct inputs

Xinmei Song et al.

Summary: In this study, we demonstrate the construction of several new and label-free electrochemical logic gates by designing G-quadruplexes with Y junction structures. Different combinations of input molecules can alter the Y junction structures and disrupt the formation of G-quadruplexes, allowing for the successful function of different logic operations.

BIOSENSORS & BIOELECTRONICS (2022)

Article Chemistry, Multidisciplinary

Scaling Up Multi-bit DNA Full Adder Circuits with Minimal Strand Displacement Reactions

Nuli Xie et al.

Summary: DNA logic circuits based on DNA molecular programming are used to implement specific algorithms using dynamic reaction networks. We have developed a compact yet efficient architecture using cooperative strand displacement reactions to construct a DNA full adder. By exploiting a parity-check algorithm, we were able to reduce the complexity of the circuit significantly compared to conventional designs and demonstrate the implementation of a 6-bit adder comparable in scale to an electronic chip.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

Article Chemistry, Multidisciplinary

Implementation of logic operations and bioanalysis based on DNA allostery-regulated nanometallic catalysis

Yuchun Guo et al.

Summary: This work presents the exquisite logic manipulation of nanometallic catalysis of DNA-templated silver nanoclusters (DNA-AgNCs) based on designative input-responsive DNA allostery and distinct inhibition effects of duplexes and triplexes on catalytic activity. A series of molecular logic gates are introduced, capable of controlling the catalytic activity of DNA-AgNCs in logic manners. The importance of this study lies in the intelligent detection of significant disease biomarkers using a low-cost and universal platform.

NANO TODAY (2022)

Review Chemistry, Multidisciplinary

DNA Logic Circuits for Cancer Theranostics

Jing Chen et al.

Summary: Cancer diagnosis and therapeutics based on DNA logic circuits, which respond to tumor-specific markers and the tumor microenvironment, have shown great potential in improving specificity and sensitivity, as well as signal amplification, to release drugs selectively.

SMALL (2022)

Article Chemistry, Multidisciplinary

A Molecular Logic Gate for Developing AND Logic Probes and the Application in Hepatopathy Differentiation

Mengqi Chen et al.

Summary: This study reports a novel molecular logic gate that enables a double-controlled release of intact functional molecules by combining two disease-associated stimuli. Compared to traditional monoresponsive probes, these AND logic probes show significantly improved signal-to-background contrast and have been successfully used in hepatopathy diagnosis.

ACS CENTRAL SCIENCE (2022)

Review Chemistry, Multidisciplinary

Emerging Approaches to DNA Data Storage: Challenges and Prospects

Andrea Doricchi et al.

Summary: This article discusses the latest advances in DNA-based data storage, highlighting its advantages over traditional storage methods, while also addressing current challenges and future directions for development.

ACS NANO (2022)

Article Biophysics

Self-assembled DNA origami-based duplexed aptasensors combined with centrifugal filters for efficient and rechargeable ATP detection

Xiaojuan Wang et al.

Summary: This study demonstrated the construction of a DNA origami biosensor for precise localization of fluorescent aptamers and quantitative detection of adenosine triphosphate (ATP). The results showed successful synthesis of origami-aptamer arrays with excellent detection sensitivity and linear relationship for ATP quantification.

BIOSENSORS & BIOELECTRONICS (2022)

Article Engineering, Environmental

Enzyme-free catalyzed self-assembly of three-dimensional hyperbranched DNA structures for in situ SERS imaging and molecular logic operations

Shuzhen Yue et al.

Summary: This paper proposes a novel DNA tetrahedron-mediated branched catalytic hairpin assembly technique, which can accelerate reaction kinetics and achieve ultra-sensitive detection and in situ imaging of microRNA-21. Moreover, it constructs a series of molecular logic gates that respond to miR-21 and miR-155, enabling multiplexed analysis of biomarkers.

CHEMICAL ENGINEERING JOURNAL (2022)

Article Nanoscience & Nanotechnology

Nanotechnology-based strategies against SARS-CoV-2 variants

Xiangang Huang et al.

Summary: This Perspective explores the potential role of nanotechnology in addressing the rise of new SARS-CoV-2 variants. Nanotechnology has been instrumental in the fight against SARS-CoV-2, particularly with the development of highly effective nanotechnology-based mRNA vaccines. However, the emergence of new variants has hindered efforts to bring an end to the pandemic, necessitating the proposal of novel strategies to tackle the crisis posed by existing and emerging SARS-CoV-2 variants.

NATURE NANOTECHNOLOGY (2022)

Article Biophysics

DNAzyme motor systems and logic gates facilitated by toehold exchange translators

Wenchan Deng et al.

Summary: This study reports a toehold-exchange translator and translator-mediated DNAzyme motor systems that enable sensitive responses to various nucleic acid targets using the same DNAzyme motor without requiring redesign. The translator efficiently converts nucleic acid targets into specific output DNA, activating the DNAzyme motor and enabling autonomous movement. By adjusting the target-binding region of the translator, the same DNAzyme motor system can respond to multiple nucleic acid targets. The study also demonstrates the construction and operation of four logic gates using the translator and DNAzyme motor, enhancing the biosensing applications of DNA motors.

BIOSENSORS & BIOELECTRONICS (2022)

Review Chemistry, Multidisciplinary

Minimally invasive nanomedicine: nanotechnology in photo-/ultrasound-/radiation-/magnetism-mediated therapy and imaging

Jiang Ouyang et al.

Summary: Traditional treatments like chemotherapy and surgery often have severe side effects and cause pain. The emergence of nanomedicines and minimally invasive therapies has brought hope to patients with malignant diseases. Minimally invasive nanomedicines combine the advantages of nanomedicines and minimally invasive therapies, effectively targeting pathological cells and minimizing side effects. This review provides a comprehensive overview of the research status and challenges of minimally invasive nanomedicines and their applications in various fields.

CHEMICAL SOCIETY REVIEWS (2022)

Review Critical Care Medicine

Hemoperfusion: technical aspects and state of the art

Claudio Ronco et al.

Summary: Hemoperfusion, a technique that removes harmful substances from plasma by adsorption, has gained renewed interest due to advancements in technology that have improved its safety and biocompatibility. Early studies were hindered by bioincompatibility, but recent developments have addressed these limitations. Hemoperfusion has shown positive effects in chronic dialysis, chronic liver disease, and drug overdose. However, the role of non-selective hemoperfusion in sepsis or inflammation still requires further investigation.

CRITICAL CARE (2022)

Review Biotechnology & Applied Microbiology

Engineering precision nanoparticles for drug delivery

Michael J. Mitchell et al.

Summary: The development of nanoparticles has shown promising clinical applications, overcoming the limitations of therapeutic interventions and biological barriers. Precision therapies have enhanced treatment efficacy through personalized interventions. Advancements in nanoparticle design aim to optimize drug delivery, improving efficacy in general applications and enabling tailored designs for precision applications.

NATURE REVIEWS DRUG DISCOVERY (2021)

Review Biotechnology & Applied Microbiology

Novel Modalities in DNA Data Storage

Cheng Kai Lim et al.

Summary: The field of storing information in DNA has been growing rapidly, with challenges such as high costs, low throughput, appropriate storage media, and scalability for commercial viability. Novel methods inspired by molecular biology techniques are being developed to address these challenges and explore potential applications.

TRENDS IN BIOTECHNOLOGY (2021)

Article Multidisciplinary Sciences

A novel art of continuous noninvasive blood pressure measurement

Juergen Fortin et al.

Summary: The continuous noninvasive blood pressure measurement system CNAP2GO presents a potential breakthrough in patient monitoring, directly measuring blood pressure using volume control technique for integration in small wearable sensors. CNAP2GO demonstrated excellent blood pressure measurement performance during surgeries, with the capability to derive cardiac output and other hemodynamic variables. The system can self-calibrate and be miniaturized for wearable use, offering significant promise for blood pressure monitoring in clinical settings.

NATURE COMMUNICATIONS (2021)

Review Chemistry, Analytical

Engineered aptamer for the analysis of cells

Xiaochen Tang et al.

Summary: Since the discovery of aptamers about 30 years ago, they have shown great potential for applications in biosensor construction and bioanalysis. However, limitations arise when dealing with more complex analytes, such as cells and living organisms, due to their excessive flexibility and high nuclease-sensitivity. Efforts have been made to develop novel engineered aptamers to expand their applications for living cell analysis, even in vivo tissues.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2021)

Article Multidisciplinary Sciences

Two-input protein logic gate for computation in living cells

Yashavantha L. Vishweshwaraiah et al.

Summary: This study presents an engineered single protein design, regulated to function as a 'two-input logic OR gate', using chemical and optogenetic regulation of focal adhesion kinase. The activation of FAK was shown to significantly increase cell multiaxial complexity in the fibrous extracellular matrix microenvironment and decrease cell motility. This work provides proof-of-principle for fine multimodal control of protein function, paving the way for constructing complex nanoscale computing agents.

NATURE COMMUNICATIONS (2021)

Article Biotechnology & Applied Microbiology

Endogenous microRNA triggered enzyme-free DNA logic self-assembly for amplified bioimaging and enhanced gene therapy via in situ generation of siRNAs

Qinghua Jiang et al.

Summary: The study introduces an endogenous microRNA-activated DNA circuit for in situ generation of siRNAs, leading to enhanced gene silencing and anti-tumor effects.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

Article Biochemical Research Methods

Minimum Free Energy Coding for DNA Storage

Ben Cao et al.

Summary: With the development of information technology, DNA storage has become a viable solution for efficiently storing large amounts of data. However, errors can occur during encoding and synthesis, leading to the proposal of a thermodynamic minimum free energy constraint to improve the quality of DNA coding sets. The Brownian multi-verse optimizer algorithm, based on the MVO algorithm, has been introduced to enhance the accuracy and robustness of DNA storage systems.

IEEE TRANSACTIONS ON NANOBIOSCIENCE (2021)

Article Biophysics

A glutathione-responsive polyphenol-Constructed nanodevice for double roles in apoptosis and ferroptosis

Hao Chen et al.

Summary: Combination chemotherapy is proposed to reduce drug doses and achieve a synergistic effect in cancer treatment. This study designed nanocomplexes combining ferroptosis and apoptosis with the help of DOX-induced ROS. The DOX-loaded nanocomplexes showed strong pro-apoptotic effect and induced ferroptosis in tumor cells, efficiently inhibiting tumor development in vivo.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

Review Chemistry, Multidisciplinary

Nucleic acid-based molecular computation heads towards cellular applications

Lanlan Chen et al.

Summary: Nucleic acid-based biocomputing devices, with programmability and biocompatibility, have shown promise in logic analysis and modulation of biological functions in cellular environments. Through rational design and chemical synthesis, these devices have demonstrated wide-ranging applications in sensing, imaging, biomedicine, and bioengineering.

CHEMICAL SOCIETY REVIEWS (2021)

Review Nanoscience & Nanotechnology

Biosensors based on DNA logic gates

Fangfei Yin et al.

Summary: Biosensors utilize biological recognition to selectively respond to specific targets, providing digital outputs for qualitative analysis in biomedical applications. Over the past decade, research on DNA logic gate-based biosensors has advanced significantly, aiming to achieve logic-gated biomedical functions.
Review Chemistry, Multidisciplinary

DNA nanotechnology-empowered nanoscopic imaging of biomolecules

Fan Li et al.

Summary: Advancements in bioimaging technologies have led to the discovery of novel biological processes at the nanoscale, but there is a constant need for improvement in spatial and temporal resolution, multiplexity, and smart responsiveness. Self-assembled DNA nanostructures show promise in developing nanoscale probes and labels for high-performance bioimaging, overcoming bottlenecks in the field. However, challenges and opportunities still lie ahead in utilizing DNA nanotechnology in bioimaging strategies.

CHEMICAL SOCIETY REVIEWS (2021)

Review Chemistry, Multidisciplinary

Phenolic-enabled nanotechnology: versatile particle engineering for biomedicine

Di Wu et al.

Summary: Phenolics play a significant role in biomedical applications, with the PEN technology gaining widespread attention. This review summarizes the fundamental mechanisms and synthetic strategies of PEN, particularly in particle engineering and the synthesis of nanohybrid materials.

CHEMICAL SOCIETY REVIEWS (2021)

Review Chemistry, Multidisciplinary

DNA nanostructure-based nucleic acid probes: construction and biological applications

Dong-Xia Wang et al.

Summary: DNA nanostructure-based probes have shown advantages such as enhanced cell internalization efficiency and accelerated reaction rate, thus improving the efficiency of applications in biosensing, imaging analysis, and cell assembly.

CHEMICAL SCIENCE (2021)

Review Materials Science, Multidisciplinary

Integrating DNA Nanotechnology with Aptamers for Biological and Biomedical Applications

Zike Huang et al.

Summary: DNA is not only important for biological roles, but also considered as an excellent engineering material with high programmability and addressability. Recent advances in DNA nano technology have enabled the design and fabrication of exquisite DNA nanostructures, providing new opportunities for technological uses. The integration of DNA nanostructures with aptamers, short single-stranded nucleic acids with molecular recognition capacity, has led to the development of powerful tools for advanced biological and biomedical applications.

MATTER (2021)

Review Chemistry, Physical

Data Storage Based on DNA

Yaya Hao et al.

Summary: In recent years, DNA as a data storage medium has shown rapid development due to its high density, reproducibility and durability. Recent advances in using artificially designed DNA materials for data storage include encoding, writing, storage, retrieving, reading, and decoding, as well as different forms of data storage strategies using DNA nanostructures.

SMALL STRUCTURES (2021)

Article Chemistry, Multidisciplinary

DNA-Based Adaptive Plasmonic Logic Gates

Jinyi Dong et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Review Multidisciplinary Sciences

DNA storage: research landscape and future prospects

Yiming Dong et al.

NATIONAL SCIENCE REVIEW (2020)

Article Chemistry, Multidisciplinary

Programmable Live-Cell CRISPR Imaging with Toehold-Switch-Mediated Strand Displacement

Yaya Hao et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Article Immunology

Modern diagnostic technologies for HIV

Nitika Pant Pai et al.

Lancet HIV (2020)

Article Biochemistry & Molecular Biology

Epigenome engineering: new technologies for precision medicine

Agustin Sgro et al.

NUCLEIC ACIDS RESEARCH (2020)

Review Chemistry, Multidisciplinary

DNA Nanotechnology-Enabled Drug Delivery Systems

Qinqin Hu et al.

CHEMICAL REVIEWS (2019)

Review Genetics & Heredity

Molecular digital data storage using DNA

Luis Ceze et al.

NATURE REVIEWS GENETICS (2019)

Review Chemistry, Analytical

DNA nanotechnology and bioassay development

Ali Ebrahimi et al.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2019)

Article Multidisciplinary Sciences

Switching the activity of Cas12a using guide RNA strand displacement circuits

Lukas Oesinghaus et al.

NATURE COMMUNICATIONS (2019)

Article Chemistry, Multidisciplinary

Aptamer Displacement Reaction from Live-Cell Surfaces and Its Applications

Long Li et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

Article Biotechnology & Applied Microbiology

Data storage in DNA with fewer synthesis cycles using composite DNA letters

Leon Anavy et al.

NATURE BIOTECHNOLOGY (2019)

Article Chemistry, Multidisciplinary

Logic-Gate-Actuated DNA-Controlled Receptor Assembly for the Programmable Modulation of Cellular Signal Transduction

Shan Chen et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Review Chemistry, Multidisciplinary

Rationally Engineered Nucleic Acid Architectures for Biosensing Applications

Mingshu Xiao et al.

CHEMICAL REVIEWS (2019)

Article Multidisciplinary Sciences

High-efficiency and integrable DNA arithmetic and logic system based on strand displacement synthesis

Haomiao Su et al.

NATURE COMMUNICATIONS (2019)

Review Chemistry, Analytical

Novel technologies for metabolomics: More for less

Paul Miggiels et al.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2019)

Review Biotechnology & Applied Microbiology

New Technologies To Enhance In Vivo Reprogramming for Regenerative Medicine

Jacqueline Larouche et al.

TRENDS IN BIOTECHNOLOGY (2019)

Review Nanoscience & Nanotechnology

DNA nanotechnology

Nadrian C. Seeman et al.

NATURE REVIEWS MATERIALS (2018)

Article Chemistry, Multidisciplinary

Engineering a 3D DNA-Logic Gate Nanomachine for Bispecific Recognition and Computing on Target Cell Surfaces

Ruizi Peng et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

Article Nanoscience & Nanotechnology

Construction of integrated gene logic-chip

Takeya Masubuchi et al.

NATURE NANOTECHNOLOGY (2018)

Article Biochemistry & Molecular Biology

Entropy-driven DNA logic circuits regulated by DNAzyme

Jing Yang et al.

NUCLEIC ACIDS RESEARCH (2018)

Article Chemistry, Analytical

Dual-input molecular logic circuits for sensitive and simultaneous sensing of multiple microRNAs from tumor cells

Ying Peng et al.

SENSORS AND ACTUATORS B-CHEMICAL (2018)

Review Chemistry, Multidisciplinary

DNA Nanostructures at the Interface with Biology

Katherine E. Bujold et al.

Review Chemistry, Multidisciplinary

Advanced Smart Nanomaterials with Integrated Logic-Gating and Biocomputing: Dawn of Theranostic Nanorobots

Andrey A. Tregubov et al.

CHEMICAL REVIEWS (2018)

Article Multidisciplinary Sciences

A CRISPR-Cas9-triggered strand displacement amplification method for ultrasensitive DNA detection

Wenhua Zhou et al.

NATURE COMMUNICATIONS (2018)

Article Multidisciplinary Sciences

Synthetic RNA-based logic computation in mammalian cells

Satoshi Matsuura et al.

NATURE COMMUNICATIONS (2018)

Article Chemistry, Multidisciplinary

Small Molecule Release and Activation through DNA Computing

Kunihiko Morihiro et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

Article Chemistry, Multidisciplinary

Multi-Arm Junctions for Dynamic DNA Nanotechnology

Shohei Kotani et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

Review Chemistry, Multidisciplinary

Chemistry-Driven Approaches for Ultrasensitive Nucleic Acid Detection

Sarah J. Smith et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

Article Multidisciplinary Sciences

Digital logic circuits in yeast with CRISPR-dCas9 NOR gates

Miles W. Gander et al.

NATURE COMMUNICATIONS (2017)

Article Chemistry, Multidisciplinary

Time-Gated FRET and DNA-Based Photonic Molecular Logic Gates: AND, OR, NAND, and NOR

Melissa Massey et al.

ACS SENSORS (2017)

Article Chemistry, Multidisciplinary

A Reversible DNA Logic Gate Platform Operated by One-and Two-Photon Excitations

Dick Yan Tam et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

Article Chemistry, Analytical

Near-Infrared Ag2S Quantum Dots-Based DNA Logic Gate Platform for miRNA Diagnostics

Peng Miao et al.

ANALYTICAL CHEMISTRY (2016)

Article Multidisciplinary Sciences

Genetic circuit design automation

Alec A. K. Nielsen et al.

SCIENCE (2016)

Review Medicine, Research & Experimental

DNA Nanotechnology for Cancer Therapy

Vinit Kumar et al.

THERANOSTICS (2016)

Article Chemistry, Multidisciplinary

Antibody Activation using DNA-Based Logic Gates

Brian M. G. Janssen et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)

Article Chemistry, Multidisciplinary

Construction of a Fuzzy and Boolean Logic Gates Based on DNA

Reza M. Zadegan et al.

SMALL (2015)

Article Chemistry, Multidisciplinary

Programmable and Multiparameter DNA-Based Logic Platform For Cancer Recognition and Targeted Therapy

Mingxu You et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)

Review Chemistry, Multidisciplinary

Nucleic Acids and Smart Materials: Advanced Building Blocks for Logic Systems

Fang Pu et al.

ADVANCED MATERIALS (2014)

Article Multidisciplinary Sciences

Amplifying Genetic Logic Gates

Jerome Bonnet et al.

SCIENCE (2013)

Article Chemistry, Multidisciplinary

Reconfigurable Three-Dimensional DNA Nanostructures for the Construction of Intracellular Logic Sensors

Hao Pei et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)

Article Chemistry, Multidisciplinary

Colorimetric Logic Gates Based on Supramolecular DNAzyme Structures

Sai Bi et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2010)

Article Chemistry, Multidisciplinary

Molecular Logic Gates Connected through DNA Four-Way Junctions

Alex Lake et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2010)

Article Chemistry, Multidisciplinary

Logic Gates and Antisense DNA Devices Operating on a Translator Nucleic Acid Scaffold

Bella Shlyahovsky et al.

ACS NANO (2009)

Article Chemistry, Multidisciplinary

Interactions of a Tetraanionic Porphyrin with DNA: from a Z-DNA Sensor to a Versatile Supramolecular Device

Alessandro D'Urso et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)

Article Multidisciplinary Sciences

Enzyme-free nucleic acid logic circuits

Georg Seelig et al.

SCIENCE (2006)

Article Chemistry, Multidisciplinary

DNA logic gates based on structural polymorphism of telomere DNA molecules responding to chemical input signals

Daisuke Miyoshi et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2006)

Article Chemistry, Multidisciplinary

DNA logic gates

A Okamoto et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)

Review Chemistry, Multidisciplinary

Deoxyribozyme-based logic gates

MN Stojanovic et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2002)