Journal
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
Volume -, Issue -, Pages -Publisher
JOHN WILEY & SONS LTD
DOI: 10.1002/ueg2.12488
Keywords
hepatocellular carcinoma; portal hypertension; radiotherapy
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This study investigated the impact of portal hypertension on ascites occurrence and radiotherapy outcome in cirrhotic patients with hepatocellular carcinoma. The results showed that the portal hypertension score and related factors were associated with the occurrence of ascites.
Background and AimsWe studied the impact of Portal hypertension (PHT) on ascites occurrence and on radiotherapy outcome in cirrhotic patients with hepatocellular carcinoma (HCC).MethodAll cirrhotic patients that received radiotherapy for HCC between 2012 and 2022 were included. Portal hypertension-Score was built using univariate analysis with the presence of esophageal varices (EV), platelet count, history of acute variceal bleeding (AVB) and spleen size. Time-to-events data were estimated using Kaplan-Meier method with log-rank and Cox-models.Results60 patients were included (female 27%, age 67 years-old, Child-Pugh A 82%, alcoholic/non-alcoholic steatohepatitis/hepatitis C virus 55/40/32%). 38% and 15% presented history of ascites and AVB respectively, 25% had large EV, 53.5% presented PHT score >= 5. 92% were BCLC-0/A, median tumor size was 30 mm. At 6 months, ascites incidence was 19% and precluded access to further HCC treatment for all patients with HCC recurrence. All PHT parameters included in the score and PHT score >= 5 (hazard ratio (HR) = 14.07, p = 0.01) were associated with ascites occurrence. Transplantation free survival and recurrence free survival at 1 year were 56% and 47% respectively. Albi grade 3 (HR = 3.01; p = 0.04) was independently associated with Transplantation free survival.ConclusionRadiotherapy should be cautiously performed in patients with PHT score >= 5 because of ascites occurrence risk precluding access to further HCC treatments. image
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