4.7 Article

Patient- and xenograft-derived organoids recapitulate pediatric brain tumor features and patient treatments

Related references

Note: Only part of the references are listed.
Article Oncology

Establishment of patient-derived organoid models of lower-grade glioma

Kalil G. Abdullah et al.

Summary: An optimized protocol was developed to establish organoids from LGG primary tissue samples, producing the first suite of these models. Patient-derived organoids recapitulated key biological features of their respective parental tumor specimens, demonstrating fidelity and potential for preclinical studies and personalized treatment assessments.

NEURO-ONCOLOGY (2022)

Article Oncology

Treatment and outcome of intracranial ependymoma after first relapse in the 2nd AIEOP protocol

Maura Massimino et al.

Summary: In patients with intracranial ependymoma, the completion of surgery, absence of symptoms at relapse, and female sex are considered favorable prognostic factors for survival after first recurrence. The impact of symptoms and completeness of surgery significantly influence survival after recurrence.

NEURO-ONCOLOGY (2022)

Article Oncology

Neoplastic and immune single-cell transcriptomics define subgroup-specific intra-tumoral heterogeneity of childhood medulloblastoma

Kent A. Riemondy et al.

Summary: This study utilized single-cell RNA sequencing and immunohistochemistry to reveal the heterogeneity of neoplastic and immune cells in medulloblastoma, identifying specific cell subpopulations related to neurodevelopment and immune cell infiltrates. The findings provide a clearer understanding of the diversity of cells that make up the microenvironment of medulloblastoma.

NEURO-ONCOLOGY (2022)

Article Clinical Neurology

Toward Improved Diagnosis Accuracy and Treatment of Children, Adolescents, and Young Adults With Ependymoma: The International SIOP Ependymoma II Protocol

Pierre Leblond et al.

Summary: The SIOP Ependymoma II trial aims to improve the outcome of ependymoma patients in childhood and adolescence. It includes randomized studies based on factors such as surgical outcome and eligibility for radiotherapy. The trial aims to increase resection rate, evaluate the effectiveness of various treatments, and identify prognostic biomarkers.

FRONTIERS IN NEUROLOGY (2022)

Review Oncology

Clinical translation of patient-derived tumour organoids- bottlenecks and strategies

Malia Alexandra Foo et al.

Summary: Multiple three-dimensional tumour organoid models assisted by multi-omics and AI have contributed to preclinical drug development and precision medicine. However, there are challenges in translating these models to clinical applications. This review identifies potential strategies to overcome these limitations.

BIOMARKER RESEARCH (2022)

Article Oncology

Cancer Statistics, 2021

Rebecca L. Siegel et al.

Summary: Every year, the American Cancer Society projects the numbers of new cancer cases and deaths in the United States, with the latest data showing a significant decline in lung cancer mortality, while prostate cancer mortality has plateaued and breast and colorectal cancer mortality have slowed. Improvements in treatment have accelerated progress against lung cancer, leading to a record drop in overall cancer mortality.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Oncology

Local and systemic therapy of recurrent ependymoma in children and adolescents: short- and long-term results of the E-HIT-REZ 2005 study

Jonas E. Adolph et al.

Summary: In recurrent ependymomas in children and adolescents, the extent of resection is the most important predictor of survival. Focal re-irradiation is a useful approach for patients who cannot achieve complete resection, but does not provide additional benefit for those with complete or near-total resection. In some cases, disease stabilization for longer periods was achieved with TMZ.

NEURO-ONCOLOGY (2021)

Review Oncology

The 2021 WHO Classification of Tumors of the Central Nervous System: a summary

David N. Louis et al.

Summary: The fifth edition of the WHO Classification of Tumors of the Central Nervous System integrates molecular diagnostics into CNS tumor classification, introduces different approaches to tumor nomenclature and grading, and emphasizes the importance of integrated diagnoses and layered reports.

NEURO-ONCOLOGY (2021)

Article Biochemistry & Molecular Biology

Long non-coding RNAs in brain tumors

Keisuke Katsushima et al.

Summary: lncRNAs play central roles in regulating gene expression in brain tumors, serving as potential therapeutic targets and biomarkers. They can either have tumor suppressive or oncogenic functions in different brain cancers.

NAR CANCER (2021)

Article Multidisciplinary Sciences

Modeling medulloblastoma in vivo and with human cerebellar organoids

Claudio Ballabio et al.

NATURE COMMUNICATIONS (2020)

Review Oncology

Pediatric Low-Grade Gliomas

Kelly L. Collins et al.

CANCERS (2020)

Article Clinical Neurology

Patient-derived orthotopic xenografts of pediatric brain tumors: a St. Jude resource

Kyle S. Smith et al.

ACTA NEUROPATHOLOGICA (2020)

Review Pharmacology & Pharmacy

Organoids for Drug Discovery and Personalized Medicine

Toshio Takahashi

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 59 (2019)

Review Clinical Neurology

Childhood brain tumors: current management, biological insights, and future directions

Ian F. Pollack et al.

JOURNAL OF NEUROSURGERY-PEDIATRICS (2019)

Article Biochemistry & Molecular Biology

Comprehensive Integration of Single-Cell Data

Tim Stuart et al.

Review Endocrinology & Metabolism

IGFBP-2 Signaling in the Brain: From Brain Development to Higher Order Brain Functions

Shumsuzzaman Khan

FRONTIERS IN ENDOCRINOLOGY (2019)

Article Multidisciplinary Sciences

DNA methylation-based classification of central nervous system tumours

David Capper et al.

NATURE (2018)

Article Biochemistry & Molecular Biology

A biobank of patient-derived pediatric brain tumor models

Sebastian Brabetz et al.

NATURE MEDICINE (2018)

Review Biochemistry & Molecular Biology

Modeling Development and Disease with Organoids

Hans Clevers

Article Neurosciences

Low-doses of cisplatin injure hippocampal synapses: A mechanism for 'chemo' brain?

Adrienne L. Andres et al.

EXPERIMENTAL NEUROLOGY (2014)

Article Oncology

Evolving of Therapeutic Strategies for CNS-PNET

Maura Massimino et al.

PEDIATRIC BLOOD & CANCER (2013)

Article Oncology

Hyperfractionated Accelerated Radiotherapy in the Milan Strategy for Metastatic Medulloblastoma

Lorenza Gandola et al.

JOURNAL OF CLINICAL ONCOLOGY (2009)

Article Medicine, General & Internal

Treatment of early childhood medulloblastoma by postoperative chemotherapy alone

S Rutkowski et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)