4.8 Article

Engineered Probiotic-Based Personalized Cancer Vaccine Potentiates Antitumor Immunity through Initiating Trained Immunity

Related references

Note: Only part of the references are listed.
Article Immunology

Inducing trained immunity in pro-metastatic macrophages to control tumor metastasis

Chuanlin Ding et al.

Summary: By inducing trained immunity, reprogrammed pre-metastatic niche myeloid cells inhibit tumor metastasis and prolong survival. The metabolic sphingolipid-mitochondrial fission pathway is identified as the mechanism for WGP-induced trained immunity.

NATURE IMMUNOLOGY (2023)

Article Engineering, Biomedical

Advances in Escherichia coli Nissle 1917 as a customizable drug delivery system for disease treatment and diagnosis strategies

Haojie Chen et al.

Summary: With the advancement in the study of bacteria within the human body, bacterial-based drug delivery system has emerged as a biomimetic platform that can retain biological functions. Escherichia coli Nissle 1917 (ECN) has gained attention as a biological carrier in the treatment of inflammatory bowel disease and tumor due to its biocompatibility and targeting ability. ECN acts as a natural capsule and can be modified or genetically engineered to enhance its function and survival in harsh environments. This review discusses the properties of ECN, its relationship with inflammation and tumor, and strategies to modify it as a delivery carrier for disease treatment.

MATERIALS TODAY BIO (2023)

Review Biochemistry & Molecular Biology

Review Metastasis

Stefanie Gerstberger et al.

Summary: Most cancer-associated deaths are caused by metastasis, which is still being studied for a better understanding and more effective treatment. Metastasis involves the acquisition of traits for dissemination, variable dormancy, and colonization of distant organs. Clonal selection, dynamic cell state transitions, and immune environment co-option are driving factors for successful metastasis. This review highlights the main principles of metastasis and presents emerging opportunities for developing better therapies.
Review Urology & Nephrology

Trained immunity - basic concepts and contributions to immunopathology

Jordi Ochando et al.

Summary: Trained immunity is a functional state of the innate immune response characterized by long-term epigenetic reprogramming. It enhances immune responses against microbial pathogens and has implications in inflammation and transplantation.

NATURE REVIEWS NEPHROLOGY (2023)

Article Multidisciplinary Sciences

Engineered skin bacteria induce antitumor T cell responses against melanoma

Y. Erin Chen et al.

Summary: Certain bacterial colonists induce a specific T cell response, even in the absence of infection. By engineering a skin bacterium to express tumor antigens, researchers were able to elicit tumor-specific T cells that infiltrate lesions and possess cytotoxic activity. This reveals the potential for commensal bacteria to be harnessed therapeutically for targeted immune responses.

SCIENCE (2023)

Article Engineering, Biomedical

Immunization against Zika by entrapping live virus in a subcutaneous self-adjuvanting hydrogel

Haibin Hao et al.

Summary: The threat of new viral outbreaks has led to an increased demand for safe and effective ready-to-use vaccines. Research has shown that a subcutaneous vaccine using a hydrogel to electrostatically trap live Zika virus can stimulate immune cells at the injection site and provide mice with effective protection against a lethal viral challenge. The hydrogel prevents the escape of viral particles and activates innate antiviral immunity. Inflammatory immune niches created by entrapping live viruses may facilitate the rapid development of safe and efficacious vaccines.

NATURE BIOMEDICAL ENGINEERING (2023)

Review Pharmacology & Pharmacy

Tumor associated macrophage and microbe: The potential targets of tumor vaccine delivery

Jipeng Jiang et al.

Summary: The occurrence and development of tumors depend on the tumor microenvironment (TME), in which tumor associated macrophages (TAMs) and microbes play important roles. By targeting TAMs and microbes, tumor vaccine delivery can remodel TME, enhance antigen specificity and immunogenicity, and contribute to the regulation of TME.

ADVANCED DRUG DELIVERY REVIEWS (2022)

Article Chemistry, Multidisciplinary

A Minimalist Binary Vaccine Carrier for Personalized Postoperative Cancer Vaccine Therapy

Jiayu Zhao et al.

Summary: A minimalist binary nanovaccine (BiVax) has been designed to integrate innate stimulating activity into the carrier to elicit robust antitumor immunity, showing promising results in inducing strong immune responses against tumor cells.

ADVANCED MATERIALS (2022)

Article Chemistry, Multidisciplinary

Bacterially Synthesized Tellurium Nanorods for Elimination of Advanced Malignant Tumor by Photothermal Immunotherapy

Yuzhu Yao et al.

Summary: Probiotic Escherichia coli Nissle 1917 is used as a bioreactor to synthesize tellurium nanorods, creating a biohybrid therapeutic platform for eliminating advanced malignant tumors through photothermal immunotherapy. The bacteria-synthesized nanorods show superior photothermal properties and can effectively suppress tumor metastasis and recurrence, with minimal acute side effects in healthy mice.

SMALL (2022)

Article Multidisciplinary Sciences

TLR4 is a regulator of trained immunity in a murine model of Duchenne muscular dystrophy

Salyan Bhattarai et al.

Summary: The authors of this study investigate the trained immunity of immune cells in Duchenne Muscular Dystrophy (DMD) and identify TLR4 as a key regulator of this process. Trained immunity contributes to dysregulated inflammation in DMD, and this mechanism is dependent on functional and epigenetic changes in TLR4 and bone marrow-derived macrophages.

NATURE COMMUNICATIONS (2022)

Article Multidisciplinary Sciences

Yeast-derived nanoparticles remodel the immunosuppressive microenvironment in tumor and tumor-draining lymph nodes to suppress tumor growth

Jialu Xu et al.

Summary: This article discusses the research progress of microbe-based cancer immunotherapy, inducing anticancer immunity through the preparation of nanoparticles of different sizes. The study found that the size of the formulations inversely correlates with their accumulation ability in tumor-draining lymph nodes, showing potential therapeutic effects.

NATURE COMMUNICATIONS (2022)

Article Multidisciplinary Sciences

The induction of peripheral trained immunity in the pancreas incites anti-tumor activity to control pancreatic cancer progression

Anne E. Geller et al.

Summary: The application of immunotherapy in pancreatic ductal adenocarcinoma has been limited, but researchers have found that fungal beta-glucan can induce trained immunity, resulting in reduced tumor burden and improved survival in mouse models. This study highlights the importance of innate immune cells in anti-tumor immunosurveillance and suggests a potential application of trained immunity in cancer therapy.

NATURE COMMUNICATIONS (2022)

Article Multidisciplinary Sciences

Re-engineered BCG overexpressing cyclic di-AMP augments trained immunity and exhibits improved efficacy against bladder cancer

Alok Kumar Singh et al.

Summary: This study re-engineered the BCG vaccine to express high levels of the PAMP molecule c-di-AMP, leading to augmented immune responses, enhanced induction of trained immunity, and improved antitumor efficacy in pre-clinical models of bladder cancer.

NATURE COMMUNICATIONS (2022)

Article Immunology

Immunisation with the BCG and DTPw vaccines induces different programs of trained immunity in mice

Natalie E. Stevens et al.

Summary: In addition to targeted immunity, vaccines can have nonspecific effects on mortality and morbidity. Live vaccines like BCG have been associated with reduced infant mortality, while some inactivated vaccines like DTPw have controversially been linked to increased mortality, particularly in high-mortality settings. The nonspecific effects of BCG are thought to be attributed to the induction of trained immunity, whereas the trained immunity induced by non-live vaccines like DTPw is poorly understood. A recent study in mice showed that DTPw vaccination induced a unique program of trained immunity compared to BCG vaccination, altering immune cell responses and chromatin accessibility. The order of administration of BCG and DTPw vaccines also influenced subsequent trained immune responses. Further studies are needed to investigate the potential consequences of DTPw-induced trained immunity in different contexts and explore if other non-live vaccines induce similar changes.

VACCINE (2022)

Review Pharmacology & Pharmacy

Progress of engineered bacteria for tumor therapy

Jin-Xuan Fan et al.

Summary: This review discusses the recent developments in bioengineering technology and nanotechnology that have led to the modification of natural bacteria for enhanced therapeutic efficiency in diseases. The review summarizes the basic modification methodologies of engineered bacteria and highlights their therapeutic performances in tumor treatment. It also provides insights into the construction of engineered colonies based on individual bacteria, offering innovative ideas for complex functions and efficient anti-tumor treatment. The limitations and challenges of using engineered bacteria for tumor therapy are also discussed.

ADVANCED DRUG DELIVERY REVIEWS (2022)

Article Chemistry, Multidisciplinary

Decorating Bacteria with Triple Immune Nanoactivators Generates Tumor-Resident Living Immunotherapeutics

Juanjuan Li et al.

Summary: This study reports a method of decorating bacteria with triple immune nanoactivators to develop tumor-resident living immunotherapeutics. The decorated bacteria show targeted tumor retention and release of drugs, achieving potent antitumor effects. This work provides a versatile platform for cancer immunotherapy.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

Review Engineering, Environmental

Nanotechnology-based multifunctional vaccines for cancer immunotherapy

Xiaoxue Xie et al.

Summary: Cancer immunotherapy, such as cancer vaccines and immune checkpoint blockade, has shown promise in specifically targeting cancer cells. However, there are challenges including side effects, long processing time, immunosuppressive tumor microenvironment, and high cost. Multifunctional nanovaccines based on nanotechnology can overcome these challenges by efficiently delivering tumor antigens and adjuvants and inducing specific antitumor immune responses.

CHEMICAL ENGINEERING JOURNAL (2022)

Review Biochemistry & Molecular Biology

Trained immunity-related vaccines: innate immune memory and heterologous protection against infections

Athanasios Ziogas et al.

Summary: The innate immune system is capable of developing memory-like features through trained immunity, which leads to enhanced immune responses and heterologous protection upon (re) infection. The cellular and molecular mechanisms underlying trained immunity provide insights for developing novel vaccine strategies against new pandemics in the future.

TRENDS IN MOLECULAR MEDICINE (2022)

Article Immunology

Parenteral BCG vaccine induces lung-resident memory macrophages and trained immunity via the gut-lung axis

Mangalakumari Jeyanathan et al.

Summary: This study demonstrates that subcutaneous BCG vaccination can induce memory alveolar macrophages (AMs) and trained immunity in the lung. The induction of memory AMs is independent of circulating monocytes and is related to the distribution of mycobacteria, alterations in the intestinal microbiome, and changes in circulating and lung metabolites.

NATURE IMMUNOLOGY (2022)

Review Oncology

Cancer vaccines: the next immunotherapy frontier

Matthew J. Lin et al.

Summary: The article discusses the current status and potential of cancer vaccines, emphasizing the need for accurate immune monitoring of early trials to advance the most promising vaccines. It also classifies cancer vaccines based on the included antigens and their colocalization with antigen-presenting cells, highlighting the challenges and opportunities in advancing these vaccines to the clinic.

NATURE CANCER (2022)

Review Medicine, Research & Experimental

Trained immunity in the mucosal diseases

Dou Yu et al.

Summary: Trained immunity, an enhanced response in the innate immune system, plays a crucial role in host defense against pathogens and tumors, but can also lead to undesirable inflammation. The immune memory of mucosal immune system is closely related to mucosal diseases outcomes, with metabolic and epigenetic changes in trained immune cells offering potential for clinical treatments.

WIRES MECHANISMS OF DISEASE (2022)

Article Chemistry, Multidisciplinary

Biopolymer Immune Implants' Sequential Activation of Innate and Adaptive Immunity for Colorectal Cancer Postoperative Immunotherapy

Guofeng Ji et al.

Summary: The biopolymer immune implant designed for post-surgical therapy of CRC shows promising results in eradicating residual tumors, inhibiting distal tumor growth, and eliciting immune memory effects, providing a valuable option for preventing tumor recurrence and metastasis.

ADVANCED MATERIALS (2021)

Article Engineering, Biomedical

Bacterial-based cancer therapy: An emerging toolbox for targeted drug/gene delivery

Dewu Lin et al.

Summary: Bacteria are increasingly being considered for targeted tumor therapy due to their intrinsic tumor tropism and ability to rapidly colonize in the favorable TME. Compared to other nano-strategies, tumor-targeting bacteria are largely unaffected by the tumor cells and microenvironment. Integration of live bacteria with anti-cancer drugs and nanomaterials can enhance targeted delivery and accumulation in tumors.

BIOMATERIALS (2021)

Article Engineering, Biomedical

Engineered porous/hollow Burkholderia pseudomallei loading tumor lysate as a vaccine

Feng-Ying Huang et al.

Summary: By engineering Burkholderia pseudomallei as a carrier, the SB-LC vaccine promotes internalization and antigen cross-presentation by DCs, inducing strong anti-tumor responses and reversing the immunosuppressive tumor microenvironment, making it a potential treatment option.

BIOMATERIALS (2021)

Review Microbiology

Trained Immunity as a Preventive Measure for Surgical Site Infections

Lieke ter Steeg et al.

Summary: New strategies to prevent surgical site infections (SSIs) are crucial in combating health care-associated infections. Enhancing the function of innate immune cells through trained immunity may reduce the risk of SSIs by improving local host defense and preventing postoperative immunoparalysis.

CLINICAL MICROBIOLOGY REVIEWS (2021)

Article Multidisciplinary Sciences

Boosting anti-PD-1 therapy with metformin-loaded macrophage-derived microparticles

Zhaohan Wei et al.

Summary: This study demonstrates that metformin-loaded mannose-modified macrophage-derived microparticles can reprogram the tumor immune microenvironment, enhance responses to anti-PD-1 therapy, and promote infiltration of CD8(+) T cells into tumor tissues.

NATURE COMMUNICATIONS (2021)

Review Biochemistry & Molecular Biology

Trained Immunity as an Adaptive Branch of Innate Immunity

Vaclav Vetvicka et al.

Summary: Trained immunity, achieved through epigenetic reprogramming, is less specific and may provide cross-protection. However, observed changes could also be influenced by immune modulators, and the question of trained immunity in cells with a short lifespan remains unresolved.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Immunology

Innate Immune Training with Bacterial Extracts Enhances Lung Macrophage Recruitment to Protect from Betacoronavirus Infection

Manuel Salzmann et al.

Summary: Training the innate immune system with orally ingested bacterial extracts has beneficial effects on infection clearance and disease outcome. In this study, the immune activating bacterial extract BV OM-85 enhanced lung macrophages, leading to faster type I interferon response to viral challenges, ultimately protecting lung tissue and promoting faster return to normal tissue homoeostasis.

JOURNAL OF INNATE IMMUNITY (2021)

Review Chemistry, Applied

Beta-D-glucan-based drug delivery system and its potential application in targeting tumor associated macrophages

Yuting Su et al.

Summary: The use of β-D-glucans as carriers in drug delivery systems is promising due to their stability, biocompatibility, and targeting specificity. Targeting TAMs is an emerging strategy in cancer immunotherapy to modulate immunity and exert anti-cancer effects.

CARBOHYDRATE POLYMERS (2021)

Review Oncology

Vaccine Therapies for Cancer: Then and Now

Michael A. Morse et al.

Summary: The development of therapeutic cancer vaccines faces challenges in clinical translation, but breakthroughs in cancer immunobiology and vaccine technologies offer hope for next-generation vaccine strategies to help cancer patients develop long-lasting anti-tumor immunity.

TARGETED ONCOLOGY (2021)

Article Multidisciplinary Sciences

Mucosal immunity-mediated modulation of the gut microbiome by oral delivery of probiotics into Peyer's patches

Sisi Lin et al.

Summary: The oral delivery of camouflaged probiotics can induce mucosal immune responses, regulate the gut microbiota, maintain gut homeostasis, and provide defense against external threats. Studies show that this approach effectively prevents intestinal barrier breakdown, bacterial translocation, and systemic inflammation.

SCIENCE ADVANCES (2021)

Review Oncology

Therapeutic cancer vaccines

Mansi Saxena et al.

Summary: Therapeutic cancer vaccines aim to induce tumor regression, eradicate minimal residual disease, establish lasting anti-tumor memory, and avoid non-specific or adverse reactions. However, challenges arise due to tumor-induced immunosuppression and immunoresistance, hindering the achievement of these goals.

NATURE REVIEWS CANCER (2021)

Review Biotechnology & Applied Microbiology

Engineering Targeting Materials for Therapeutic Cancer Vaccines

Priscilla S. Briquez et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

Article Urology & Nephrology

Trained immunity as a molecular mechanism for BCG immunotherapy in bladder cancer

Jelmer H. van Puffelen et al.

NATURE REVIEWS UROLOGY (2020)

Article Chemistry, Multidisciplinary

Bacteria and bacterial derivatives as drug carriers for cancer therapy

Zhenping Cao et al.

JOURNAL OF CONTROLLED RELEASE (2020)

Review Materials Science, Biomaterials

Therapeutic Vaccines for Cancer Immunotherapy

Jie Wang et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

Article Biochemistry & Molecular Biology

Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity

Lydia Kalafati et al.

Review Immunology

Defining trained immunity and its role in health and disease

Mihai G. Netea et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Review Immunology

Dendritic cells in cancer immunology and immunotherapy

Stefanie K. Wculek et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Article Biotechnology & Applied Microbiology

Therapeutic targeting of trained immunity

Willem J. M. Mulder et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

Review Immunology

Targeting Tumor-Associated Macrophages in Cancer

Paulina Pathria et al.

TRENDS IN IMMUNOLOGY (2019)

Article Chemistry, Multidisciplinary

Bacterium-Mimicking Vector with Enhanced Adjuvanticity for Cancer Immunotherapy and Minimized Toxicity

Binbin Zheng et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

Review Medicine, Research & Experimental

Targeting innate immunity for tuberculosis vaccination

Shabaana A. Khader et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Review Immunology

Potential Role of Gut Microbiota in Induction and Regulation of Innate Immune Memory

Shikha Negi et al.

FRONTIERS IN IMMUNOLOGY (2019)

Review Biochemistry & Molecular Biology

Bacteria-cancer interactions: bacteria-based cancer therapy

Mai Thi-Quynh Duong et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2019)

Article Nanoscience & Nanotechnology

In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment

Qian Chen et al.

NATURE NANOTECHNOLOGY (2019)

Review Biotechnology & Applied Microbiology

Delivery technologies for cancer immunotherapy

Rachel S. Riley et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

Review Biotechnology & Applied Microbiology

Bacterial components as naturally inspired nano-carriers for drug/gene delivery and immunization: Set the bugs to work?

Fatemeh Farjadian et al.

BIOTECHNOLOGY ADVANCES (2018)

Article Biochemistry & Molecular Biology

Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity

Ioannis Mitroulis et al.

Article Multidisciplinary Sciences

A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors

Tingting Wang et al.

NATURE COMMUNICATIONS (2018)

Review Chemistry, Multidisciplinary

Biomaterials for vaccine-based cancer immunotherapy

Rui Zhang et al.

JOURNAL OF CONTROLLED RELEASE (2018)

Review Cell Biology

Hypothesis: stimulation of trained immunity as adjunctive immunotherapy in cancer

Mihai G. Netea et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2017)

Article Chemistry, Multidisciplinary

Biomimetically Engineered Demi-Bacteria Potentiate Vaccination against Cancer

Dezhi Ni et al.

ADVANCED SCIENCE (2017)

Review Biochemistry & Molecular Biology

Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy

Padmanee Sharma et al.

Review Biotechnology & Applied Microbiology

Genetic engineering of probiotic Escherichia coli Nissle 1917 for clinical application

Bingming Ou et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2016)

Review Multidisciplinary Sciences

Trained immunity: A program of innate immune memory in health and disease

Mihai G. Netea et al.

SCIENCE (2016)

Article Chemistry, Multidisciplinary

Engineering Nanoparticle-Coated Bacteria as Oral DNA Vaccines for Cancer Immunotherapy

Qinglian Hu et al.

NANO LETTERS (2015)

Article Multidisciplinary Sciences

Injectable cryogel-based whole-cell cancer vaccines

Sidi A. Bencherif et al.

NATURE COMMUNICATIONS (2015)

Review Immunology

Innate immune memory: towards a better understanding of host defense mechanisms

Jessica Quintin et al.

CURRENT OPINION IN IMMUNOLOGY (2014)

News Item Multidisciplinary Sciences

Cancer Immunotherapy

Jennifer Couzin-Frankel

SCIENCE (2013)